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INFLAMMATORY PERIODONTAL DISEASE INVOLVES _________ RISK FACTORS / INDICATORS |
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SYSTEMIC FACTORS INCLUDE: |
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•OWN BODY •SUSCEPTIBILITY TO DISEASE |
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INFLAMMATORY PERIODONTAL DISEASES ARE INITIATED AND PROGRESS DUE TO: |
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•THE ACCUMULATION OF BIOFILM IN THE AREA OF THE GINGIVAL SULCUS |
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WHICH TYPES OF MICROORGANISMS ARE A PART OF THE BIOFILM? |
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•USES RESEARCH FINDINGS AND APPLIES THEM TO EVERYDAY CLINICAL PRACTICE |
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THE PRIMARY RISK FACTOR FOR PERIODONTAL DISEASE IS: |
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•PROTECTS THE BACTERIA FROM EXTERNAL SOURCES, SUCH AS ANTIBIOTICS/ANTIMICROBIALS |
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THERE ARE OVER ____ BACTERIAL SPECIES IN ORAL BIOFILMS |
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•700 •LESS THAN 10% OF THEM ARE PATHOGENIC •MORE THAN 90% OF THEM ARE NORMAL ORAL MICROBIOTA |
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HEALTH ASSOCIATED BACTERIA INCLUDE: |
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•GRAM POSITIVE •AEROBIC •SACCHAROLYTIC •NON-MOTILE |
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SACCHAROLYTIC BACTERIA UTILIZE __________ |
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DISEASE ASSOCIATED BACTERIA INCLUDE: |
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•GRAM NEGATIVE •ASACCHAROLYTIC •ANAEROBIC •MOTILE |
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ASACCHAROLYTIC BACTERIA UTILIZES ________ |
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WHAT ARE THE COMPONENTS OF BIOFILM? |
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•BACTERIA (PRODOMINATE) •CELLS: -EPITHELIAL -GHOST CELLS -WBC -RBC |
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BACTERIA FOUND IN HEALTH INCLUDE: |
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•STREP SANGUIS •STREP MITIS •VEILLONELLA SPECIES •ACTINOMYCES NAESLUNDII •ACTINOMYCES VISCOSUS |
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•FORMS WITHIN MINUTES •CONTAINS PROTEINS AND GLYCOPROTEINS (FROM SALIVA AND CREVICULAR FLUID) •INFLUENCE COLONIZATION OF BACTERIA •PROVIDES RECEPTORS FOR BACTERIAL ATTACHMENT |
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BACTERIA THAT ADHERE TO SURFACE PROTEINS ARE CALLED |
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PHASE I OF ORAL BIOFILM FORMATION: |
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•BEGINS IN 1-2 DAYS OF PLAQUE ACCUMULATION WITH NO REMOVAL •BACTERIA EXTEND LATERALLY AND PERPENDICULARLY FROM THE SURFACE TO FORM PARALLEL, PALISADING LAYERS OF BACTERIA |
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PHASE II OF ORAL BIOFILM FORMATION |
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•BEGINS IN 2-4 DAYS OF NO REMOVAL •GRAM (+) RODS AND GRAM (-) COCCI FORM •THERE IS A SPACE BETWEEN LAYERS (PHASES) WHICH PROVIDE ANAEROBIC ENVIRONMENTS FOR THE BACTERIA •MATRIX FORMATION BEGINS |
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PHASE III OF ORAL BIOFILM FORMATION |
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•BEGINS IN 4-7 DAYS OF NO REMOVAL •PLAQUE EXTENDS CORONALLY AND THICKENS •INFLAMMATION CONTINUES IN 7-11 DAYS •BACTERIA MIGRATE SUBGINGIVALLY |
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•STRICT OR OBLIGATE ANAEROBES |
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IRRITATION TO THE GINGIVAL MARGIN CAUSES: |
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•ALTERATION IN THE SULCUS |
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A DEEPENED SULCUS PROTECTS ____________ |
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•MICROBIOTA •ALSO, ALLOWS MORE VIRULENT TYPES OF BACTERIA TO LIVE, CAUSING TOXIC PRODUCTS TO BE PRODUCED |
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WHAT ARE THE 3 TYPES OF SUBGINGIVAL BACTERIAL BIOFILM? |
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•TOOTH ASSOCIATED (ATTACHED) •TISSUE ASSOCIATED •UNATTACHED |
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NUTRIENTS FOUND IN GINGIVAL CREVICULAR FLUID, SUCH AS HEMIN-CONTAINING COMPOUNDS, ENHANCE THE GROWTH OF ______________ |
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•PORPHYROMONAS AND PREVOTELLA SPECIES |
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WHICH TYPES OF BACTERIA INVADE THROUGH THE EPITHELIUM INTO LP AND BONE? |
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•ACTINOBACILLUS ACTINOMYCETEMCOMITANS •PORPHYROMONAS GINGIVALIS •SPIROCHETES |
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SUPRAGINGIVAL BACTERIA GROWTH CAN BE INHIBITED BY: |
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•INTRAORAL ABRASION •SALIVARY FLOW •ANTIMICROBIAL AGENTS |
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•AKA: LIPOOLIGOSACCHARIDE (LOS) PREVIOUSLY (LPS) |
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ENDOTOXINS ARE A COMPONENT OF ___________ |
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•GRAM (-) BACTERIAL CELL WALL |
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ENDOTOXINS ARE RELEASE WHEN: |
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•BACTERIA DIE AND LYSIS OCCURS |
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•INFLAMMATION AND BONE DESTRUCTION |
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ENDOTOXINS ARE FOUND LOOSELY ATTACHED TO: |
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•IS A TOXIN RELEASED BY SOME BACTERIA THAT DAMAGES THE HOST BY KILLING PMNs |
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•ARE PRODUCED AND RELEASED BY SUBGINGIVAL BACTERIA WITHIN THE PERIODONTAL POCKET •DESTROY CONNECTIVE TISSUE (COLLAGEN AND GROUND SUBSTANCE) |
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COMMON ENZYMES THAT BREAK DOWN PERIODONTAL TISSUES |
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•MATRIX METALLOPROTEINASES (MMPs) |
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INDIRECT MECHANISMS OF BACTERIAL ACTION ARE: |
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•IMMUNOPATHOLOGIC MECHANISMS AND COMBINED MECHANISMS |
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IMMUNOPATHOLOGIC MECHANISMS |
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•BACTERIAL ANTIGENS THAT STIMULATE THE IMMUNE RESPONSE •CAN BE DESTRUCTIVE AS WELL AS PROTECTIVE |
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•TRANSMISSION OF SALIVA (MOST COMMON) |
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