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Peptic Ulcer Disease (PUD) H. Pylori Treatment
Peptic Ulcer Disease (PUD) H. Pylori Treatment
13
Pharmacology
Professional
08/29/2012

Additional Pharmacology Flashcards

 


 

Cards

Term
What is the recommended therapy to treat an H. pylori infection?
Definition

Triple therapy with an anti-secretary agent (preferably a PPI) + 2 antibiotics (clarithromycin and amoxicillin or metronidazole) for 14 days.

Term
What's secondary treatment for H. pylori should primary treatment fail?
Definition

Quadruple therapy due to recent failrues with triple therapy. Would be a PPI plus bismuth, metronidazole, and tetracycline for 10 - 14 days (can use Helidac or Pylera).

Term
What's third line treatment for H. pylori (i doubt the naplex will ask this)?
Definition

Sequential Therapy: a PPI with amoxicillin for 5 days, followed by a PPI with clarithromycin and tinidazole for 5 days.

Term
Are substitutions permissable in H. pyloir eradication therapy?
Definition

Do not make substitutions in H. pylori eradication regimens. Histamine2 - receptor blockers should not be substituted for a PPI. Likewise, other antibiotics in the same class should not be substituted in H. pylori eradication regimens (for example, do not use ampicillin instead of amoxicillin).

Term
[image]
Definition
Statement. Not a question.
Term
PPI cautions of note?
Definition

caution with concurrent use of itraconazole, ketoconazole, calcium carbonate and iron due to reduced absorption from increased pH.

Term
Which cyp enzyme do PPIs inhibit?
Definition

2C19; may prevent conversion of clopidogrel to active form

Term
Clarithromycin is a major inhibitor of?
Definition

3A4 major inhibitor

 

Term
Administration notes regarding tetracycline?
Definition

can chelate (complex) with aluminum, magnesium, calcium, iron and zinc leading to decrased drug absorption. The administration time must be seperated (2 hours before and 2 hours after, usually)

Term
Consumption of what should be avoided while taking metronidazole
Definition
avoid use of alochol
Term

Counseling: If taking bismuth subsalicylate, the pink tablets are chewable while the other medications are swallowed. If taken with aspirin and ringing in the ears occurs, contact your doctor. Counsel on symptoms of bleeding. Bismuth subsalicylate may cause temporary and harmless darkening of the tongue and/or black stool.

 

Definition
Statement. Not a question.
Term
Tetracylcine warning and/or counseling?
Definition

Do not use if pregnant or in children less than or equal to 8 years of age. Oral contraceptive may be less effective. Use a back-up form of contraception, such as condoms, during antibiotic therapy. This medication will make your skin more sensitive to the sun and you may burn more easily. Use sunscreen.

Term
For Helidac or Pylera therapy, take what?
Definition

take additional PPI (Pylera) or Histamine - 2 blocker (Helidac) for entire course of therapy, as directed. The histamine - 2 blocker is recommended for an additional 14 days after the end of Helidac therapy.

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