Term
What is the recommended therapy to treat an H. pylori infection? |
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Definition
Triple therapy with an anti-secretary agent (preferably a PPI) + 2 antibiotics (clarithromycin and amoxicillin or metronidazole) for 14 days. |
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Term
What's secondary treatment for H. pylori should primary treatment fail? |
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Definition
Quadruple therapy due to recent failrues with triple therapy. Would be a PPI plus bismuth, metronidazole, and tetracycline for 10 - 14 days (can use Helidac or Pylera). |
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Term
What's third line treatment for H. pylori (i doubt the naplex will ask this)? |
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Definition
Sequential Therapy: a PPI with amoxicillin for 5 days, followed by a PPI with clarithromycin and tinidazole for 5 days. |
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Term
Are substitutions permissable in H. pyloir eradication therapy? |
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Definition
Do not make substitutions in H. pylori eradication regimens. Histamine2 - receptor blockers should not be substituted for a PPI. Likewise, other antibiotics in the same class should not be substituted in H. pylori eradication regimens (for example, do not use ampicillin instead of amoxicillin). |
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Term
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Definition
Statement. Not a question. |
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Term
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Definition
caution with concurrent use of itraconazole, ketoconazole, calcium carbonate and iron due to reduced absorption from increased pH. |
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Term
Which cyp enzyme do PPIs inhibit? |
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Definition
2C19; may prevent conversion of clopidogrel to active form |
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Term
Clarithromycin is a major inhibitor of? |
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Definition
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Term
Administration notes regarding tetracycline? |
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Definition
can chelate (complex) with aluminum, magnesium, calcium, iron and zinc leading to decrased drug absorption. The administration time must be seperated (2 hours before and 2 hours after, usually) |
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Term
Consumption of what should be avoided while taking metronidazole |
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Definition
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Term
Counseling: If taking bismuth subsalicylate, the pink tablets are chewable while the other medications are swallowed. If taken with aspirin and ringing in the ears occurs, contact your doctor. Counsel on symptoms of bleeding. Bismuth subsalicylate may cause temporary and harmless darkening of the tongue and/or black stool.
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Definition
Statement. Not a question. |
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Term
Tetracylcine warning and/or counseling? |
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Definition
Do not use if pregnant or in children less than or equal to 8 years of age. Oral contraceptive may be less effective. Use a back-up form of contraception, such as condoms, during antibiotic therapy. This medication will make your skin more sensitive to the sun and you may burn more easily. Use sunscreen. |
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Term
For Helidac or Pylera therapy, take what? |
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Definition
take additional PPI (Pylera) or Histamine - 2 blocker (Helidac) for entire course of therapy, as directed. The histamine - 2 blocker is recommended for an additional 14 days after the end of Helidac therapy. |
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