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Peptic Ulcer Disease
Clinical Medicine Test 4
16
Medical
Graduate
10/18/2010

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Cards

Term
5 risk factors for higher occurrence of peptic ulcer disease?
Definition
1) Age
2) Male
3) H.pylori infection
4) NSAID use
5) stress
Term
What percentage of people with H. pylori develop infections?
Definition
10-20%
Term
Where do NSAID ulcers typically occur?
Definition
stomach
Term
What is the most important mechanism for NSAID ulcer formation?
Definition
inhibiton of COX-1
Term
What percentage of NSAIDS are ulcerogenic and when is the greatest risk?
Definition
1) All are ulcerogenic
2) between 7 and 30 days of therapy
Term
what is the tx for H. pylori?
Definition
OCLAM
1) O-omeprazole
2) CL-Clarithromycin
3) AM-Amoxicillin
Term
What develops in 95% of patients with gastrinoma?
Definition
peptic ulcers
Term
What are acute stress ulcers common with?
Definition
serious medical/surgical conditions

1) head injury
2) burn injury
3) majory surgery
4) life-threatening illnesses
Term
Pain description for peptic ulcers
Definition
1) epigastrium
2) gnawing/burning
3) relieved by eating
Term
What is peptic ulcer disease the most common cause of?
Definition
acute upper GI bleeding
Term
What is typically seen in patients with a bleeding ulcer?
Definition
azotemia w/BUN/serum creatine ratios >20:1
Term
What is the most accurate test for peptic ulcer diagnosis?
Definition
endoscopy-100% specificity, >90% sensitivity
Term
What should you give for people with non-H. pylori duodenal ulcers?
Definition
antisecretory medication
Term
What will usually heal an ulcer that has failed to heal?
Definition
increasing dosage of antisecretory or prolonging its course
Term
What is the most common cause of ulcer recurrences?
Definition
H. pylori
Term
what is the most effective treatment for complicated bleeding ulcers?
Definition
thermal application for cautery after volume stabilization
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