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Penicillins (PCNs)
Penicillins (PCNs)
25
Pharmacology
Professional
08/18/2012

Additional Pharmacology Flashcards

 


 

Cards

Term
MOA of Penicillins (PCNs)
Definition

Beta-lactams that inhibit bacterial cell wall synthesis by binding to one or more pencillin-binding proteins (PBPs) thus inhibiting final step in bacterial cell wall synthesis.

Term
Concentration dependent or time dependent?
Definition
time dependent killing
Term
Brand name for Amoxicillin
Definition
Amoxil, Moxatag
Term
Brand name for Amoxicillin + Clavulanate
Definition
Augmentin
Term
What does the clavulanate do?
Definition

Used to combat antibiotic resistance. Certain bacteria secret beta-lactamase which inactivates penicillins.

 

Term
Amoxicillin is mostly active against what?
Definition

Gram positive cocci (staph and strep) and some gram negative.

 

no atypical coverage.

 

Term
Amoxicillin is the DOC for what?
Definition

acute otitis media

H pylori regimen

pregnancy

prophylaxis for endocarditis

Term
Name two possible serious side effects?
Definition

Agranulocytosis (severly lowered white blood cell count)

 

Increased LFTs

Term
Pregnancy category of Amoxicillin
Definition

B

Term
Brand name for Ampicillin
Definition
Principen
Term
Brand name for Ampicillin + sulbactam
Definition
Unasyn
Term
Brand name for Penicillin
Definition
Pen VK
Term
Brand name for Piperacillin + tazobactam
Definition
Zosyn
Term
What does tazobactam do?
Definition

Used to combat bacteria that secrete beta-lactamase that would otherwise render pipericilling inactive.

 

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Term
What does the sulbactam do?
Definition

Beta-lactamase inhibitor. Used to combat bacteria that secrete beta-lactamases that would otherwise render ampicillin inactive.

 

Term
Should Augmentin be refrigerated or not?
Definition
Yes. Must be refrigerated.
Term
Should Amoxil oral suspension be refrigerated or not?
Definition
May be refrigerated to improve taste.
Term
When should Moxatag be taken?
Definition
Within one hour of finishing a meal.
Term
Should Pen VK be refrigerated or not?
Definition
Yes. Must be refrigerated.
Term
When to take Pen VK?
Definition
On an empty stomach.
Term
Reduce dose in renal impairment for all PCNs except for?
Definition
Nafcillin and Oxacillin
Term
Brand name for Ticarcillin + clavulanic acid?
Definition
Timentin
Term
Brand name for Ticarcillin?
Definition

None. It isn't formulated by istself. Always formulated with clavulanic acid.

Term
Uricosuric agents such as probenecid and allopurinol do what to the levels of PCNs?
Definition

Increase

 

Note: uricosuric = increase urine acid excretion

Term
PCNs may do what to oral contraceptives?
Definition
Decrease effectiveness of oral contraceptives - check package insert for individual drug.
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