Term
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Definition
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Term
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Definition
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Term
| Beta lactamase-resistant penicillins |
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Definition
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Term
| Extended spectrum penicillins |
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Definition
| ticarcillin, piperacillin |
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Term
|
Definition
bactericidal
time-dependent
post-antibiotic effect
eagle effect - when you reach too high of a local concentration can lose efficacy |
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Term
|
Definition
extracellular
poor penetration inside cells |
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Term
| Regular penicillin Action |
|
Definition
Gram + including anaerobes
Pasteurella |
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Term
|
Definition
Gram + including anaerobes
Pasteurella and some extension to other Gram - |
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Term
| Antistaphylococcal Penicillins Action |
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Definition
Gram + including betalactamase + and anaerobes
less efficient against Gram + anaerobes and Gram - |
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Term
| Anti-pseudomonal penicillins |
|
Definition
Gram + and Gram - including anaerobes
less efficient against Gram + |
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Term
|
Definition
synergy with aminoglycosides
wall disruption increases aminoglycoside penetration
cannot be mixed in a syringe because will precipitate
synergy with beta lactamase inhibitors |
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Term
|
Definition
degraded by GI amidases, bacterial beta lactamases, acidity, alkalinity
poor oral bioavailability
poor efficacy in presence of pus and tissue debris |
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Term
|
Definition
Type A
effects on gut flora - GI upset
cardiac arrest with rapid IV injection of K-salts or procaine
CNS toxicity with procaine formulas with horses
Type B
frequent compared to other drugs
risk for cross-reactivity between penecillins and cephalosporins |
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Term
|
Definition
Pencillins A - don't use in guinea pigs or rabbits because of GI upset
Anti-pseudomonal penicllinins
never use empirically
never use as first line
limited vet use only if confirmed pseudomonas infection |
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