Term
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Definition
| both prevalence and mortality of asthma are ... |
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Term
Damage/loss of airway epithelium
Collagen deposit below basement membrane causing thickening
Increased vascularity and inflammation
Loss of elastic fibers
Smooth muscle thickening(? hyperplasia or hypertrophy) |
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Definition
| Long term irreversible changes in airways (remodeling) include... |
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Term
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Definition
Antigen binds with IgE on mast cell
causing inflammation |
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Term
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Definition
Decreased warmth and saturation of inhaled air
Exaggerated cholinergic response
causing bronchoconstriction and inflammation |
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Term
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Definition
Epithelial cell damage
Viral antigen binds with IgE
Exaggerated cholinergic response
Causing bronchoconstriction, bronchospasm and degranulation |
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Term
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Definition
Daily fluctuations in secretion of catecholaminespredominence of cholinergic influence
causing bronchoconstriction |
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Term
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Definition
Exaggerated cholinergic response- parasympathetic (acetylcholine) or sympathetic (epinephrine)
causing bronchoconstriction
May be treated with inhaled bronchodilators and/or inhaled corticosteriods |
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Term
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Definition
| prolonged asthma that responds poorly to treatment |
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Term
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Definition
| fulminant form of asthma with rapid and unexpected progression from apparently controlled asthma to death from respiratory arrest |
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Term
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Definition
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Term
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Definition
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Term
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Definition
| PEFR [peak expiratory flow rate <25% |
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Term
| peak expiratory flow rate |
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Definition
| simple way to obtain an objective assessment of the degree of obstruction |
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Term
quick relievers
If you are using these more than twice a week than your long term controllers aren’t doing their job |
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Definition
Short acting inhaled beta 2 agonists
Systemic corticosteroids (oral prednisone is the one you mostly use)
Anticholinergics |
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Term
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Definition
Inhaled corticosteroids
Long acting beta 2 agonists
Cromolyn (don’t use much anymore), nedocromil
Leukotriene modifiers (important; singulair?)
Methylxanthine |
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Term
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Definition
Also reduce mucous secretion, inhibit mast cell degranulation, increase ciliary motion, decrease cell membrane permeability, enhance water and chloride transport across membrane
bind with beta receptors on smooth muscles and via cyclic AMP cause smooth muscle relaxation. |
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Term
| wheezing, dyspnea, and coughing |
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Definition
| classic manifestations of asthma |
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Term
| hyperersonance on percussion |
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Definition
| percussion of the chest reveals.. |
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Term
| long term control asthma meds |
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Definition
- inhaled corticosteriods
- cromolyn sodium and nedocromil
- long acting Beta 2 antagonists
- methylxanthines
- leukotriene modifiers |
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Term
| short acting control asthma meds (rescue meds) |
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Definition
- beta 2 antagonists
- anticholinergics
- systemic corticosteriods |
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