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Peds Test 3
Hematology
47
Nursing
Graduate
07/16/2013

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Term
Hematopoietic System
Definition
Spleen, Blood, Bone Marrow, Liver, Kidneys
Term
Plasma Contents
Definition
90% water, 10% solutes (albumin, lytes, proteins)
Term
Protein contents in plasma
Definition
clotting factors, globulins, circulating antibodies, fibrinogen
Term
RBC life cycle
Definition
120 days
Term
Aplastic anemia patho
Definition
failure to produce RBC
Term
Chronic disease anemia patho
Definition
hemorrhage leads to cell loss while excessive fluid leads to dilution of RBC concentration
Term
WBC life span
Definition
a few days to a few weeks
Term
Neutropenia
Definition
abnl % of neutrophils compared to total WBC
Term
Leukocytosis
Definition
Increase in # of circulating WBC often d/t infection
Term
Platelet characteristics
Definition
Irregularly shaped, colorless, with sticky surface
Term
Thrombocytopenia
Definition
abnl decrease in # of platelets ex are sequestration, destruction (ITP), decreased production
Term
Hemophilia A
Definition
Deficiency of factor VIII
Term
Hemophilia B
Definition
Deficiency of factor IX
Term
Von Wildebrands Disease
Definition
Deficient component of factor VIII, generally is not serious
Term
Disseminated intravascular coagulation
Definition
results from cancer, sepsis, hypotension, OB complications,
Term
Multiple myeloma
Definition
Cancerous disorder of plasma cells, pathologic fractures are common
Term
Hgb panic levels
Definition
less than 5, more than 20 (nl 11-16)
Term
Hct panit levels
Definition
less than 15, more than 60 (nl is 35-44)
Term
Components of coagulation profile
Definition
Partial thromboplastin time, prothrombin time, platelet count, fibrinogen, platelet function analysis
Term
Nl platelet range
Definition
150,000-400,000
Term
Bone marrow aspiration
Definition
Done in posterior iliac crest when >3y old
Term
Transfusion reason packed RBC
Definition
anemia
Term
Transfusion reason fresh frozen plasma
Definition
coagulation factors
Term
3 transfusion rxns
Definition
hemolytic, allergic, febrile
Term
hemolytic rxn
Definition
immune response against transfused cells, antigens recognize foreign proteins stimulating B lymphocytes to produce antibodies
Term
In an allergic transfusion rxn, MD may order
Definition
washed RBCs
Term
Type C hemophilia
Definition
lack of factor XI
Term
Most dangerous bleed
Definition
intracranial
Term
Products to treat hemophilia
Definition
fresh frozen plasma, cryoprecipitate, factor VIII, fibrin glue
Term
Fibrin glue
Definition
mixture of fibrinogen and thrombin, can be applied topically
Term
No saliclate products in
Definition
hemophiliac
Term
DIC
Definition
thrombosis and hemorrhage occur, renal involvement=hematuria, pulmonary involvement, cutaneous involvement
Term
In DIC
Definition
no rectal temps
Term
ITP
Definition
antibodies destroy platelets, preceded by viral illness (flu, mono, varicella, URI, vaccine)
Term
Acute ITP
Definition
Occurs btw 1 and 6 years
Term
Chronic ITP
Definition
older than 10 years, female
Term
Severe ITP tx
Definition
IV gamma globulin 2-5 days to block antibody production, corticosteroids to enhance vascular stability, IV anti-D to stimulate platelet production
Term
sickling may be triggered by
Definition
fever and emotional or physical stress
Term
Sickle cell crisis
Definition
pain, splenomegaly, hemolytic crisis, stroke, kidney ischemia
Term
splenic sequestration
Definition
sudden and quickly progressing splenic enlargement, left upper quadrant pain vomiting
Term
Aplastic crisis
Definition
trigger by virus or depletion of folc acid, diminished production and increased destruction of RBCs
Term
In bleeding disorders, demerol is contraindicated bc
Definition
increases the risk of seizures
Term
Thalassemia
Definition
structural or quantitative abnlities in hemoglobin
Term
Types of thalassemia
Definition
alpha or beta, depending on which part is lacking, cooley's anemia (severe)
Term
Thalassemia major cause of death
Definition
heart failure and infection
Term
Causes of aplastic anemia
Definition
exposure to drugs, chemicals, toxins, infection, idiopathic, Fanconi's
Term
Jaundice becomes visible when serum bilirubin levels
Definition
exceed 7.0 mg/dl
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