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Pediatric Dermatology part 2
Exam 3
142
Medical
Graduate
04/17/2015

Additional Medical Flashcards

 


 

Cards

Term
Fungal Infections
Definition

Tinea capitis

Tinea corporus

Tinea cruris

Tinea pedis

Tinea unguium (onychomycosis)

Tinea versicolor

Candida albicans infections

Term
Thickened, broken off hairs with erythema and scaling of underlying scalp
Definition
Tinea Capitis
Term
Diffuse scaling of the scalp and pustules are also seen
Definition

Tinea Capitis

 

Term
Etiology: Microsporum canis and Trichophyton tonsurans
Definition

Tinea Capitis

 

Term

Tinea Capitis

Diagnostics:

Definition
Fungal Cx
Term
Tinea Capitis Management
Definition
Griseofulvin 20mg/kg/d
Term
Presents either as annular marginated plaques with a thin scale and clear center or as an annular confluent dermatitis
Definition

Tinea Corporis

 

Term

Most common organism:

Trichophyton

Mentagrophytes

Trichophyton rubrum

M canis

Definition

Tinea Corporis

 

Term
Diagnosis: made by scraping thin scales from the border of lesion, dissolving them in 20% potassium hydroxide (KOH) and examining for hyphae
Definition
Tinea Corporis
Term
Tinea Corporis Management
Definition
Topical treatment with imidazole, allylamines, benzylamine or ciclopirox BID for 3-4 weeks
Term
Symmetrical, sharply marginated lesions in inguinal areas; the lesion border is usually active to some degree with pustules or vesicles (unless the lesion is chronic). The background rash is red to reddisn-brown and is usually a symmetric macule with fairly well-demarcated borders. The rash usually spares the scrotum and is often pruritic; acute rashes also may have a burning quality.
Definition
Tinea Cruris
Term

Most common organisms : T rubrum, T mentagrophytes, and Epidermophyton floccosum

Occurs predominantly in adolescent and young adult men

Definition
Tinea Cruris
Term
Tinea Cruris Management
Definition
Topical therapy is usually a sufficient treatment for tinea cruris. Therapies include terbinafine cream or sprady applied once daily for one week and butenafine 1% cream applied once daily for 2 weeks
Term

Caused by same dermatophyte species as tinea cruis.

Most common in adolescents

Definition
Tinea Pedis
Term
Risk factors: exposure to moist environment and maceration of the skin
Definition
Tinea Pedis
Term
___ typically appears as a white macerated area between the toes, although a more diffuse dry scaling process often caused by T. rubrum ("moccasin type") may also occur. Another pattern of presentation is characterized by an inflammatory vesiculobullous eruption occurring primarily on the soles of the feet.
Definition
Tinea Pedis
Term
Tinea Pedis Management
Definition

Topical Antifungal agents such as terbinafine

applied once daily for one week or butenafine 1% applied once daily for 2 weeks

Term
Infection of the finger or toenails and is a subset of onychomycosis, a broader category of infections that also include yeast and nondermatophyte molds
Definition
Tinea Unguium (Onychomycosis)
Term
Loosening of the nail plate from the nail bed (onycholysis) giving yellow discoloration is the first sign, followed by thickening of the distal nail plate and then scaling and a crumbly appearance of the entire nail surface
Definition
Tinea Unguium (Onychomycosis)
Term
Risk factors in adolescents include associated tinea pedis, improperly fitting shoes, and diabetes
Definition
Tinea Unguium (Onychomycosis)
Term
T. rubrum most common pathogen
Definition
Tinea Unguium (Onychomycosis)
Term
Diagnostics: KOH examination and fungal culture
Definition
Tinea Unguium (Onychomycosis)
Term
Tinea Unguium (Onychomycosis) Management
Definition

Terbinafine for adolescents

Griseofulvin in children

Term
Superficial infection caused by Malassezia globosa, a yeast like fungus
Definition
Tinea Versicolor
Term
Characteristically causes polycyclic connected hypopigmented macules and very fine scales in areas of sun-induced pigmentation.
Definition
Tinea Versicolor
Term
Tinea Versicolor Management
Definition
Application of selenium sulfide (Selsun) 2.5% suspension, zinc pyrithione shampoo, or topical antifungals.
Term
Causes diaper dermatitis, thrush, fissures at the angles of the mouth (perleche), and periungual erythema and nail plate abnormalities (chronic paronychia).
Definition
Candida Albicans Infections
Term
Characterized by sharply defined erythematous patches, sometime with eroded areas. Pustules, vesicles, or papules may be present as satellite lesions.
Definition
Candida Albicans Infections
Term

Found in moist areas

Common in children who have recently received an antibiotic

Definition
Candida Albicans Infections
Term
Candida Albicans Infections Management
Definition

Topical imidazole cream

Nystatin suspension for oral thrush

(Tx nystatin topical)

Term
Viral Infections
Definition

Herpes Simplex

Varicella

Molluscum Contagiosum

Warts

Term
Painful grouped vesicles or erosions on a red base
Definition
Herpes Simplex
Term
In infants and children, lesions from ___ are most commonly seen on the gingiva, lips and face.
Definition
Herpes Simplex type 1
Term
____ lesions are seen on the genitalia and in the mouth of adolescents.
Definition
Herpes Simplex type 2
Term

Incubation period: 2-12 days

Prevalence: ___ neonatal and young children

___ adolescents

Definition

HSV 1

HSV 2

Term
History: maternal history, skin lesions, oral lesions, contact with people with ___, unprotected sex
Definition
Herpes
Term
Neonatal infection: non specific, vesicular rash or bullae
Definition
Herpes Simplex Virus
Term

Gingivostomatitis: Most common presentation during childhood.

Fever and irritability precede the development of vesicular lesions on the lips, gingiva and tongue

Risk for dehydration

Improve in 3-5 days

Definition
Herpes Simplex Virus
Term
Vulvovaginitis: genital lesions begin as vesicles and progress to ulcers before crusting over
Definition
Herpes Simplex Virus
Term
Diagnostics: PCR viral culture, rapid immunofluorescent test, Tzanck smear
Definition
Herpes Simplex Virus
Term
Herpes Simplex Virus Management
Definition
Acyclovir oral and/or topical, symptomatic relief for gingivostomatitis
Term
Grouped vesicles in a dermatome, usually on the trunk or face
Definition
Varicella-Zoster
Term
Undergoes same series of changes as herpes lesions; papule, vesicle, pustule, crust, slightly depressed scar
Definition
Varicella-Zoster
Term
Lesions of primary ___ appear in crops and different stages of lesions present at the same time.
Definition

Varicella

(Varicella-Zoster)

Term
A poxvirus that induces the epidermis to proliferate, forming a pale papule
Definition
Molluscum Contagiosum
Term
Consist of umbilicated, flesh colored papules in groups found anywhere on the body
Definition
Molluscum Contagiosum
Term
Molluscum Contagiosum Management
Definition
Immunological or cytodestructive, if left untreated, they resolve within months to years
Term
Skin colored papules with rough surfaces caused by infection with HPV
Definition
Warts
Term
Virus induces the epidermal cells to proliferate, thus resulting in growth
Definition

Warts

 

Term
____ are smoother and smaller than common warts and often seen on the face.
Definition

Flat Warts

 

Term

30% spontaneously resolve in 6 months

 

Definition

Warts

 

Term
Warts Management
Definition

Immunological (topical imiquimod, oral cimetidine, intralesional candida antigen injection, squaric acid contact therapy)

Cytogestruction

Topical salicylic acid

Flat warts: tretinoin gell or topical imiquimod (Aldera) cream for 3-4 weeks

Term
Infestations
Definition

Scabies

Pediculoses

Pinworms

Term
Linear burrows about the wrist, ankles, finger webs, and anterior axillary folds.
Definition
Scabies
Term

Often there are excoriations, honey colored crusts and pustules from secondary infection

Affects all age groups

Definition
Scabies
Term

Transmission by close personal contact with infested human

 

Definition
Scabies
Term

Mites can live isolated from the body for 2-3 days

300 million cases of ___ annually

Definition
Scabies
Term
Following exposure, signs and symptoms develop in 10-30 days after infestation
Definition
Scabies
Term

Etiology: female mites S. Scabiei

History: pruritus, other family members

Definition
Scabies
Term

Evolution of rash:

Characteristically changes of time both is appearance and distribution

May consist of burrows, papules and vesicular lesions

Recurrent clusters of vesicles and pustules and occur over time

Definition
Scabies
Term

Physical Exam:

In older children: rash involves webs of fingers, axillae, arms, wrists, waistline and genitalia

Definition
Scabies
Term

Physical Exam:

In younger children: may include palms, soles, head, neck, and face

Definition
Scabies
Term

Physical Exam:

A burrow, the characteristic lesions of scabies in present in 90-95% of pt and forms a lazy "s" shape with a broad base and punctate brown-black dote at leading edge of mites path

Definition
Scabies
Term
Diagnostics: skin scaping
Definition
Scabies
Term
Scabies Management
Definition

5% permethrin cream, apply as single overnight application and repeat in 7 days

Hygiene, contagion precautions

Term

Infestation of head, body, or anogenital region

Presence of excoriated papules and pustules and Hx of severe itching at night

Definition
Lice (Pediculosis)
Term

Common in children 3-12

Affects all socioeconomic groups

Less common in African Americans

Not influenced by hair hygiene

Gelatinous nits adhere tightly to the hair shaft

Definition
Head Lice
Term

Found on persons with poor hygiene

Common in extremem conditions such as crowding or homeless

Definition
Body Lice
Term

Most common in adolescents and young adults

May be found crawling among pubic hairs or in seams of underwear

Blue-black macules found dispersed through pubic region

Definition
Pubic lice
Term

History: pruritus, infested contact

Physical exam: nits within 1 in of scalp

Definition

Lice (Pediculosis)

Head Lice

Term

Physical Exam:

Pinpoint, erythematous macules, papules, wheals or excoriations

Definition

Lice (Pediculosis)

Body Lice

Term
Lice (Pediculosis) Management
Definition

Permethrin (Nix) 1% cream rinse, 1st line therapy, neurotoxic to lice, ovicidal, residue on hair kills newly hatching nymphs, 10 min application to damp hair

Pyrethrins (Rid), neurotoxic to lice, low ovicidal activity, reduced efficacy due to resistance, 10 min application, repeat in 7-10 days to kill newly hatched

Malathion (ovida) 0.5%, true ovicidal activity, highly effective, requires 8-12 hr application on dry hair, repeat in 7 days if lice still present, high risk of flammability, not for children under 24 mo, safety not established under 6 years.

Treat all family members affected

wash bedding, towels, etc. in hot water

Seal anything not washable in bag for 14 days

Treat comes and hairbrushes

Term
Infection by small white nematode (round worm) enterobius vermicularis
Definition
Pinworms
Term

Occur in school aged children

Incidence: 5-15%, more prevalent in temperate climates

Definition
Pinworms
Term
Pathophysiology: E. vermicularis eggs are ingested in hatched in the human's stomach and duodenum, then the larvae migrate to the ileum and cecum. The adults copulate in the cecum. The pregnanct female ___ migrates from the cecum to the anus around 5 weeks later and deposits eggs on the perianal skin causing pruritis
Definition
Pinworms
Term
Etiology: ingestion of organism through fecal oral transmission
Definition
Pinworms
Term

History: Nighttime itching, small white visible worms at night

Prognosis: reinfection common

Definition
Pinworms
Term

Diagnostics: Stool sample for O and P

Transparent tape test

Definition
Pinworms
Term
Pinworms Management
Definition

Mebendazole 100mg PO once may repeat in 2 weeks

Treat all contacts, decontaminate environment, keep fingernails short and avoid nail biting

Term

Raised, pruritic circumscribed erythematous papules

Transient and typically last several hours

Definition
Urticaria
Term

Single lesions may coalesce as they enlarge, forming generalized, raised, erythematous areas

Females 3:2

Definition
Urticaria
Term

Pathophysiology:

Immune mediated

Non-immune mediated

Autoimmune mediated

Definition
Urticaria
Term

Viral infections

Parasitic infections

Bacterial infections

Medications

Foods

Contrast

Insect venom

Natural remedies

Definition
Etiology of Acute Urticaria
Term

Idiopathic

Physical (dermatographism, cholinergic, cold, aquagenic)

Mast cell disease

Systemic disease (rheumatologic, neoplasms, parasitic infection, autoimmune)

Definition
Etiology of Chronic Urticaria
Term

History: description of the rash, duration, viral symptoms? new foods or beverages, new exposure to perfumes or chemicals?

Diagnostics: none unless indicated by history and exam

Definition
Urticaria
Term
Physical Exam: Classic wheal and flare rash, respiratory, facial or neck edema?
Definition
Urticaria
Term
Similar but non-urticarial entities:
Definition

Angioedema

Anaphylaxis

Term
Urticaria Management
Definition

Emergent if difficulty breathing or other signs of anaphylaxis (Epi 0.01 L/kg of the 1:1,000 solution SC/IM)

First line

Second generation non-sedating antihistamine (Zyrtec, Claritin, Allegra)

First generation antihistamine (more effective/sedaating)- Benadryl, Hydroxyzine

Second Line- Increase 2nd generation H1 antagonist dose for age

Third Line- Addition of a second non sedating 2nd generation antihistamine, Corticosteroids

Observe for complications: anaphylaxis

Term
Dermatitis
Definition

Atopic Dermatitis

Nummular Eczema

Contact Dermatitis

seborrheic Dermatitis

Keratosis Pilaris

Pityriasis alba

Term

Also known as eczema

Incidence: 1 in 5 children

Definition
Atopic Dermatitis
Term

Prevalence: 30-70% family history

Worse in winter

Risk factor: genetics

Definition
Atopic Dermatitis
Term

Histologic findings are dependent on the stage of ____

Lymphocytes can be seen infiltrating the epidermis

Definition
Atopic Dermatitis
Term
Acute form shows spongiosis and intercellular edema that can lead to vesicle formation
Definition
Atopic Dermatitis
Term
The chronic form is characterized by epidermal psoriasiform hyperplasia and hyperkeratosis
Definition
Atopic Dermatitis
Term

Etiology:

Multifactorial with genetic, environmential, physiologic and immunologic facotrs

 

Definition
Atopic Dermatitis
Term

Etiology:

Elevated IgE levels

Up to 70% have family Hx

Definition
Atopic Dermatitis
Term
History: age of onset, location, prior treatment, bathing habits, family hx, hay fever, excessive dryness
Definition
Atopic Dermatitis
Term

Clinical Presentation:

Intensely pruritic erythematous papules

Excoriations, vesiculations and serous exudates

Definition
Atopic Dermatitis
Term

Clinical Presentation:

Dry skin

Involves face, scalp, and extensor surfaces

Definition
Atopic Dermatitis
Term

Diagnosis based on clincial features

Pruritus, chronically relapsing course, morphology and distribution of skin lesions

Definition
Atopic Dermatitis
Term
Elevated serum IgE levels
Definition
Atopic Dermatitis
Term

Complications:

Ocular complications

Infection

Definition
Atopic Dermatitis
Term
Atopic Dermatitis Management
Definition

Avoidance of irritants and allergens

Hydration

Moisturizers and Occlusives

Corticosteroids

Topical Calcineurin Inhibitors

Tar Preparations

Wet Dressings

Antibiotics

Antipruritics

Term
There is no cure for ___, control is aim of treatment of this chronic condition.
Definition
Atopic Dermatitis
Term
Characterized by numerous symmetrically distributed coin-shaped patches of ermatitis. May be acute oozing and crusted or dry scaling.
Definition
Nummular Eczema
Term
Nummular Eczema Management
Definition
Same as atopic dermatitis, may need more potent topical steroids
Term
Contact Dermatitis Two types:
Definition

Primary irritant

Allergic eczematous

Term
Acute inflammatory reaction of the skin associated with the wearing of diapers
Definition
Diaper Dermatitis
Term
___- due to occlusive contact with urine and feces and the skin
Definition

Irritant contact dermatitis

(Diaper Dermatitis)

Term
Secondary infection by candida common
Definition
Diaper Dermatitis
Term
Diaper Dermatitis Management
Definition
Remove cantactants, eliminate maceration, frquent diaper changes, apply barrier cream
Term
Characterized by erythematous, scaly or crusted eruption over the area rich in sebaceous glands
Definition
Seborrheic Dermatitis
Term
Etiology: pityrosporum oval, hereditary immuno-dysfunction, atomospheric humidity
Definition
Seborrheic Dermatitis
Term
Seborrheic Dermatitis Management
Definition

Selenium culfide

Shampoo, topic weak corticosteroid

1% hydrocortisone

Term
Follicular papules containing a white inspissated scale, individual lesions are discrete and may be erythematous. Prominent on the extensor surfaces of upper arms, thighs, buttocks, and cheeks.
Definition
Keratosis Pilaris
Term
Keratosis Pilaris Management
Definition
Keratolytics and skin hydration
Term

White scaly macular areas with indistinct borders seen over extensor surfaces of extremities.

Sun exposure exaggerrates

Definition
Pityriasis Alba
Term
Pityriasis Alba Management
Definition
Low-potency topical corticosteroid
Term
Papulosquamous eruptions
Definition

Pityriasis rosea

Psoriasis

Term

Pink to red, oval plaques with fine scales

Christmas tree pattern

Definition
Pityriasis Rosea
Term

Generalized eruption preceded by a herald path

 

Definition
Pityriasis Rosea
Term

Common in school aged and adolescents

Presumed viral origin

Definition
Pityriasis Rosea
Term
Pityriasis Rosea Management
Definition
Exposure to natural sunlight
Term
Erythematous papules and plaques with thick, white scales
Definition
Psoriasis
Term
Pathogenesis: immune-mediated inflammation, increased epidermal turnover
Definition
Psoriasis
Term
Commonly follows strep infection, 3-8mm papules covered with thick white scales, seen on trunk
Definition
Guttate psoriasis
Term
Marked by thick, large scaly plaques 5-10cm over elbows, knees, scalp
Definition
Chronic Psoriasis
Term
Psoriasis Management
Definition

Topical corticosteroids

Second line: Topical vitamin D3 medications such as calcitriol

Topical retinoids

Crude coal tar

Refer to dermatologist

Term
Complete hair loss in a localized area
Definition
Alopecia Areata
Term

Immunologic

50% regrow hair naturally within 12 months

Definition
Alopecia Areata
Term
Alopecia Areata Management
Definition
Super potent topical steroids, minoxidil, anthralin
Term
Reactive Erythema
Definition

Erythema Multiforme

Drug erruptions

Term
Begins as papules that alter develop a dark center and tehn evolve into lesions with central bluish discolorations or blisters.
Definition
Erythema Multiforme
Term
Characteristic target lesions
Definition
Erythema Multiforme
Term

Suspected causes: HSV, drugs (especially sulfonamides), Mycoplasma

Spontaneous resolution in 10-14 days

Definition
Erythema Multiforme
Term
Erythema Multiforme Management
Definition
Symptomatic management
Term
Steven-Johnson Syndrome: diagnosed when severe involvement of conjunctiva, oral cavity, and genital mucosa. Requires  admission for hydration
Definition
Erythema Multiforme
Term
Drugs produce urticarial, morbilliform, scarlantiniform, pustular, bullous, or fixed skin eruptions
Definition
Drug Eruptions
Term

May appear within minutes, most occur 7-14 days

Dress syndrome: drug eruption with fever, eosinophilia and systemic symptoms

Definition
Drug Eruptions
Term
Treatment of Skin Disorders
Definition

Topical

Wet dressings

Topical Glucocorticoids

Term
Topical Therpy
Definition

Aimed at preserving normal skin physiology

Preferred because can be given in optimal concentrations to the desired site

Dry, scaly skin treated using barriers to prevent evaporation

Oils and ointments prevent evaporation for 8-12 hrs

Term
Principles of Topical Dermatologic Therapy
Definition

Topical dermatologic treatments include

Cleansing agents

Absorbent dressings (eg hydrocolloid patches or powder) and super-absorbent powders

Anti-infective agents

Anti-inflammatory agents

Astringents (drying agents that precipitate protein and shrink and contract the skin)

Emollients (skin hydrators and softeners)

Keratolytics (agents that soften, loosen, and facilitate exfoliation of the squamous cells of the epidermis)

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