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Pediatric Board Review
Toxicology
17
Biology
Professional
07/30/2013

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Term
Causes of miosis
Definition
Parasympathetic effect
COPS
Cholinergics, clonidine
Opiates, organophosphates
Pencyclidine, pilocarpine
Sedatives
Term
Causes of mydriasis
Definition
Anticholinergics, antihistamines, antidepressants, sympathomimetics (amphetamine, cocaine, LSD)
Term
Cases in which activated charcoal should NOT be used
Definition
CHEMICAL CamP
Caustics, hydrocarbons, electrolytes, metals, iron, cyanide, alcohols, lithium, camphor, phosphorus
Term
Acetaminophen ingestion: Treatment
Definition
ABCs, activated charcoal, check level 4 hours after ingestion, if toxic given acetylcysteine, monitor liver enzymes and coags
Term
Anion gap
Definition
MUDPILES
methanol, uremia, DKA, phenols, iron, INH, lactate, ethanol, salicylates
Term
Salicylate ingestion
Definition
Remember oil of wintergreen
GI symptoms, respiratory symptoms, CNS symptoms, fever, tinnitus, anion gap metabolic acidosis
Supportive care, lab monitoring, activated charcoal, alkalinize urine
Term
TCA ingestion
Definition
anticholinergic activty, inhibit cardiac sodium channels, tachycardia, hypertension, widened QRS, prolonged QT, coma, convulsions, cardiac dysrhythmias, acidosis
Treat with activated charcoal, alkalize serum, lidocaine for dysrhythmias
Term
Hydrocarbons
Definition
mineral spirits, kerosene, gasoline, lamp oil, pesticides
Choking, gagging, wheezing, respiratory distress, CNS depression, fever
Supportive care
Term
Ethanol ingestion
Definition
Results in hypoglycmia as it inhibits hepatic gluconeogenesis
High anion gap
Term
Methanol ingestion
Definition
Windshield washer fluid, antifreeze, canned heat, picnic stove fuel
Inhibits mitochondrial respiration
malaise, visual disturbance (snowstorm), optic nerve damage (blindness), severe metabolic acidosis
Classic triad of visual complaints, abdominal pain, metabolic acidosis
Treat with support, folate, hemodialysis
Term
Ethylene glycol
Definition
Antifreeze, radiator fluid, coolants
Similar to methanol, makes calcium oxalate crystal, respiratory problems, ARDS, seizures, renal failure, metabolic acidosis
Thiamine, pyridoxine, hemodialysis
Term
Organophosphate ingestion
Definition
Pesticides, nerve agents
cholinergic symptoms causing DUMBELS
Diarrhea, urination, miosis, bronchospasm, emesis, lacrimation, salivation
Treat with activated charcoal, atropine, 2-PAM
Term
Ingestions causing hypothermia
Definition
Opiates, sedatives, alcohol
Term
Ingestions causing hyperthermia
Definition
salicylates, anticholinergics, amphetamines
Term
SSRI toxidromes
Definition
Hyperreflexia, myoclonus, hyperthermia, autonomic instability
Term
Anticholinergic toxidromes
Definition
Agitation, hallucinations, dilated pupils, red color, dry skin, fever
Term
Antidotes
Definition
Organophosphates: atropine
Iron: Deferoxamine
Methanol, ethylene glycol: Ethanol
Carbon monoxide: Oxygen
Methemoglobinemia: Methylene blue
Acetaminphen: N-acetylcysteine
Nrarcotics: naloxone
Anticholinergics: physostigmine
B-blockers: glucagon
TCAs: sodium bicarbonate
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