Term
| what is the most common malignancy in children? |
|
Definition
| leukemia followed by brain tumours |
|
|
Term
| what is amplification of the n-myc oncogene associated with in neuroblastoma? |
|
Definition
|
|
Term
| there is a translocation in chromosome 11 and 22. what is the diagnosis? |
|
Definition
|
|
Term
| doxorubicin has a specific side effect what is it? |
|
Definition
|
|
Term
| cisplatin chemotherapy can cause which 2 side effects? |
|
Definition
| renal failure and deafness |
|
|
Term
| which chemotherapy agent can cause heamorrhagic cystitis? |
|
Definition
|
|
Term
|
Definition
|
|
Term
| commonest leukemia in childhood? |
|
Definition
|
|
Term
| what prophylaxis is given to those on chemo to prevent infection with pneumocystitsi carniini |
|
Definition
|
|
Term
| common presentations of neuroblastoma |
|
Definition
abdominal mass crossing midline
pallor
weight loss
bone pain
limp
hepatomegaly |
|
|
Term
| less common presentations of neuroblastoma |
|
Definition
paraplegia
cervical lymphadenopathy
proptosis
periorbital bruising
skin nodules |
|
|
Term
| features of neuroblastoma |
|
Definition
ix: raised urine catecholamine levels, a mass that crosses the midline suggest neuroblastoma
confirmed: with biopsy, bone marrow sampling and MIBG scan with or without a bone scan |
|
|
Term
| what is the commonest renal tumour of childhood? |
|
Definition
wilms tumour
80% of pts present before 5 years of age |
|
|
Term
| features of langherhans cell histiocytosis |
|
Definition
seborrhoeic rash
widespread soft tissue infiltration
bone pain, swelling, fracture
diabetes insipidus |
|
|
Term
| abc that can trigger heamolysis in G6PD deficiency ? |
|
Definition
sulphanomides
quinilones
nitrofurantoin |
|
|
Term
| main causes of red cell aplasia in newborn |
|
Definition
congenital infection with parvovirus
diamond blackfan anemia
the reticulocyte count will be LOW |
|
|
Term
|
Definition
non thrombocytopenic:
HSP
sepsis
trauma
thrombocytopenic:
ITP
leukeamia
DIC |
|
|
Term
|
Definition
permethin or
malathion or
benzyl benzoate |
|
|
Term
| what is hereditary angioedema due to? |
|
Definition
C1 esterase inhibitor deficiency or dysfunction
it is AD |
|
|
