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Drug-Drug Interactions: CYP Enzymes
24
Medical
Graduate
02/10/2009
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Term
Warfarin
 Definition
Substrate of CYP2C9; CYP3A4; CYP1A2
Term
Theophylline
 Definition
Substrate of CYP1A2
Term
Cyclosporine
 Definition
Substrate of CYP3A4
Term
Estrogens
 Definition
Substrate of CYP3A4
Term
Macrolide antibiotics
 Definition
Inhibitor of CYP3A4
Term
Erythromycin
 Definition
Inhibitor of CYP3A4
Term
Clarithromycin
 Definition
Inhibitor of CYP3A4
Term
Azole antifungals
 Definition
Inhibitor of CYP3A4
Term
Itraconazole
 Definition
Inhibitor of CYP3A4
Term
Ketoconazole
 Definition
Inhibitor of CYP3A4
Term
Ritonavir (HIV protease inhibitor)
 Definition
Inhibitor of CYP3A4
Term
Grapefruit Juice
 Definition
Inhibitor of CYP3A4
Term
Fluoxetine
 Definition
Inhibitor of CYP2D6
Term
Quinidine
 Definition
Inhibitor of CYP2D6
Term
Fluoroquinolone antibiotics
 Definition
Inhibitor of CYP1A2
Term
Ciprofloxacin
 Definition
Inhibitor of CYP1A2
Term
Cimetidine
 Definition
Inhibitor of CYP1A2; CYP3A4
Term
Amiodarone
 Definition
Inhibitor of CYP1A2; CYP3A4; CYP2C9
Term
Rifampin
 Definition
Inducer of CYP3A4; CYP2C(family)
Term
Carbamazepine
 Definition
Inducer of CYP3A4; CYP2C9; CYP2D6
Term
Phenobarbital
 Definition
Inducer of CYP3A4; CYP2C(family); CYP2D6
Term
Phenytoin
 Definition
Inducer of CYP3A4; CYP2C8; CYP2C19; CYP2D6
Term
St. John’s Wort
 Definition
Inducer of CYP3A4
Term
Cigarette smoke
 Definition
Inducer of CYP1A2
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