Shared Flashcard Set

Details

pda II exam 1 (witt)
exam 1 (witt)
43
Pharmacology
Professional
01/29/2010

Additional Pharmacology Flashcards

 


 

Cards

Term
Ketamine
Definition
blocks NMDA channel, thus inhibiting the opening and depolarization
Term
Phencyclidine (PCP)
Definition
blocks NMDA channel, thus inhibiting the opening and depolarization
Term
Vigabatrin
Definition
inhibits the GABA transaminase enzyme (which causes higher levels of GABA,which reduces membrane excitability) and is use to inhibit seizures
Term
Muscimol
Definition
GABA-A Competitive agonist (binds at same site as GABA)

Increase Cl- content within the cell
Term
Picrotoxin
Definition
GABA-A Antagonist

(pro-convulsants) decrease the opening frequency and mean open time of the Cl- channel
Term
Baclofen
Definition
GABA-B receptor agonist
(reduce spasticity associated with motor disorders, Huntingtons Chorea)

reduces voltage Ca++ gated conductance, and increases K+ conductance out of the cell
Term
Phaclofen
Definition
GABA-B receptor antagonist (experimental)
Term
Strychnine
Definition
Glycine receptor antagonist

causes massive excitation and soon after death (pesticide)
Term
Clonidine
Definition
presynaptic alpha 2 agonist, reduces NE lowers blood pressure
Term
Atomoxetine (Strattera®)
Definition
selective NE reuptake inhibitor at presynaptic cleft, used to treat (ADHD)
Term
Cocaine
Definition
inhibit NET, which prolongs and potentiates the effects of NE
Term
Ondansetron
Definition
5-HT3 receptor (excitatory ionotropic receptors)antagonist used in preventing and treating vomiting caused by radiation therapy in cancer patients
Term
Buspirone
Definition
5-HT1a agonist used to treat anxiety (decrease cAMP resulting in neuronal inhibition)
Term
Galantamine (Razadyne®)
Definition
Alzheimer's disease treatment
cholinesterase inhibitor, mild to moderate AD may also act as a nicotinic and muscarinic (M1) agonist
Term
Rivastigmine (Exelon®)
Definition
Alzheimer's disease treatment
cholinesterase inhibitor, mild to moderate AD
Term
Donepezil (Aricept®)
Definition
Alzheimer's disease treatment
cholinesterase inhibitor, mild to moderate AD
Term
Memantine (Namenda®)
Definition
N-methyl D-aspartate (NMDA) antagonist

For treatment of moderate to severe AD.

Because NMDA antagonists work very differently from cholinesterase inhibitors, the two types of drugs can be prescribed in combination.
Term
Levodopa (L-dopa)
Definition
Metabolic precursor to Dopamine. Tyrosine hydroxylase is
normally the rate limiting enzyme, for L-Dopa formation, thus giving
L-dopa directly bypasses the rate limiting step, leading to increased
dopamine synthesis. L-dopa is taken up by remaining dopamine
neurons in the brain if it can get there. The major problem with L-
Dopa, is that it is significantly metabolized in GI and peripheral
tissues. L-Dopa can be converted to dopamine by dopa-decarboxylase
in the periphery and then degraded peripherally by peripheral enzymes
(MAO), thus preventing L-Dopa from getting where it needs to go (the brain). To prevent this problem, L-Dopa is given with Carbidopa.
Term
Carbidopa
Definition
Dopa decarboxylase inhibitor

Does not cross the BBB, thus it inhibits L-Dopa from being
converted to dopamine in the periphery and ensures L-Dopa gets into
the brain. Since it doesn’t cross the BBB, dopa decarboxylase in the
brain can convert L-Dopa into dopamine. Diminishes metabolism of
Levodopa. Reduces dosing concentration side-effects, as you no longer
have to give tons of L-dopa in order to get it into the brain.
Term
(Sinemet®)
Definition
mixed preparation of L-Dopa and Carbi-dopa
Term
Bromocriptine
Definition
D2 dopamine receptor agonist

Little response in patients who do not respond to L-dopa

Parkinson's disease treatment drug that mimics dopamine activity D2 dopamine receptor agonist
Term
Pergolide
Definition
Parkinson's disease treatment drug that mimics dopamine activity D1/D2 dopamine receptor agonist
Term
Amantadine
Definition
Parkinson's disease treatment antiviral

Less potent than L-dopa, but has fewer side-effects. Mechanism of action in helping PD is poorly understood.
Term
Selegiline (L-deprenyl)
Definition
Parkinson's disease treatment
MAOi-B
Term
Entacapone
Definition
a COMT inhibitor (not a dopamine eplacement drug): reduces breakdown of dopamine formed from L-Dopa, thus prolonging its effect
Term
Stalevo
Definition
mixed preparation of L-Dopa and Carbi-dopa and Entacapone
Term
Benztropine
Definition
Parkinson's disease treatment muscarinic acetylcholine receptor antagonist

Muscarinic acetylcholine receptors exert an inhibitory effect on dopaminergic nerve terminals, suppression of which compensates for a lack of dopamine.
Term
Trihexyphenidyl
Definition
Parkinson's disease treatment muscarinic acetylcholine receptor antagonist

Muscarinic acetylcholine receptors exert an inhibitory effect on dopaminergic nerve terminals, suppression of which compensates for a lack of dopamine.
Term
Haloperidol
Definition
Huntington's disease treatment
dopamine antagonist
Term
Prednisolone (i.e. a corticosteroid)
Definition
Corticosteroids work by decreasing immune system antibody production and by reducing myelin swelling and inflammation (multiple sclerosis treatment)
Term
Interferon-Beta (e.g. Avonex, Betaseron, Rebif)
Definition
multiple sclerosis treatment
regulates immune system
Term
Glatiramer acetate (Copaxone®, formerly known as copolymer-1)
Definition
first non-interferon, nonsteroidal medication that effectively reduces new brain lesions

thought to stimulate T cells in the body’s immune system to change from harmful, pro-inflammatory agents to beneficial, anti-inflammatory agents that work to reduce inflammation at lesion sites
Term
Mitoxantrone (Novantrone®)
Definition
antineoplastics (i.e. cancer-drugs)

It acts in MS by suppressing the activity of T cells, B cells, and macrophages that are thought to lead the attack on the myelin sheath
Term
Halothane
Definition
Potent anesthetic (inhaled)

Weak analgesic

Bradycardia and potental cardiac arrhythmias

Hypotension (phenylephrine: vasoconstriction)

Heavily metabolized in the liver, to toxic hydrocarbons with repeated use not hepatotoxic in children, and has pleasant odor, so used with kids

Malignant Hyperthermia (excessive Ca++ release from sarcoplasmic reticulum skeletal muscle) results in acidosis, muscle contraction, and increased body temp
Term
Dantrolene
Definition

neuromuscular blocker, blocks calcium channels (inhaled)

 

hyerthermia

Term
Enflurane
Definition
Similar to Halothane (less potent, faster induction and recovery, less toxicity) (inhaled)

Can cause seizures and Malignant hyperthermia
Term
Isoflurane
Definition
Similar to Halothane and Enflurane but even low side-effect profile (less potent, fast induction and recovery, less toxicity, no-seizure effect) (inhaled)

Most widely used
Term
Nitrous Oxide
Definition
Rapid induction and recovery (i.e. low blood-gas coefficient) (inhaled)

Weak general anesthetic (but low anesthetic potency, must be coadministered often with a volatile anesthetic)

Strong Analgesic

Can cause a transient diffusion hypoxia (retards oxygen uptake), but this is usually only important with patients with respiratory conditions
Term
Thiopental
Definition
(barbiturate) Intravenous anesthetic

CNS depressant

very lipid soluble but short acting (thus used as an induction agent)

Poor analgesic

Anesthetic action stops due to redistribution to other organs
Term
Etomidate
Definition
(non-barbituate) Intravenous anesthetic

Similar to thiopental

Thought to act via GABA-A

Used only as an induction agent

Does not induce cardiac and respiratory depression

Frequent involuntary muscle movements
Term
Propofol
Definition
(Intravenous anesthetic)

Very rapidly metabolized, thus rapid recovery

Used for induction or maintenance of anesthesia

Poor analgesia (thus requires coadministration of opioids)

Lowers intracranial pressure
Term
Ketamine
Definition
Short acting non-barbituate
(Intravenous anesthetic)

Provides “Dissociative Anesthesia” with sensory loss, sedation, amnesia, and immobility (also patient may appear awake but does not feel pain or remember)

Increases blood-flow, blood-pressure and cardiac out-put

Used mostly in children due to enhanced hallucinations in adults
Term
Lidocaine
Procaine
Bupivicaine
Definition
local anesthetic
Supporting users have an ad free experience!