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PDA EXAM 1
neurological disorder drugs, anesthetics
46
Pharmacology
Graduate
01/28/2010

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Cards

Term
ketamine
Definition
blocks NMDA receptor
Term
PCP
Definition
blocks NMDA receptor
Term
vigabatrine
Definition
inhibits GABA-T-->higher levels of GABA, reduced membrane excitability
Term
muscimol
Definition
competitive GABAa agonist (increased Cl- in the cell)
Term
picrotoxin
Definition
GABAa antagonist (decreases opening frequency, less Cl- enters cell)
Term
baclofen
Definition
GABAb receptor agonist (controls excessive motor movements, Huntington's disease)
Term
phaclofen
Definition
GABAb receptor antagonist (experimental)
Term
strychinine
Definition
glycine receptor antagonist (causes massive excitation)
Term
clonidine
Definition
presynaptic alpha 2 agonist, reduces NE lowers blood pressure
Term
strattera
Definition
inhibit NET, increased NE (ADHD)
Term
cocaine
Definition
inhibit NET, increased NE
Term
ondansetron
Definition
5-HT3 antagonist, prevents vomiting in cancer patients
Term
buspirone
Definition
5-HT1 agonist used to treat anxiety
Term
galantamine
Definition
Alzheimer's disease treatment
cholinesterase inhibitor, mild to moderate AD
may also act as a nicotinic and muscarinic (M1) agonist
Term
rivastigmine
Definition
Alzheimer's disease treatment
cholinesterase inhibitor, mild to moderate AD
Term
Donepezil (Aricept)
Definition
Alzheimer's disease treatment
cholinesterase inhibitor, mild to moderate AD
Term
tacrine
Definition
Alzheimer's disease treatment
cholinesterase inhibitor, mild to moderate AD
Term
memantine (Namenda)
Definition
Alzheimer's disease treatment
NMDA antagonist, moderate to severe AD
Term
levodopa
Definition
Parkinson's disease treatment
dopamine replacement drug
dopamine precursor
Term
carbidopa
Definition
Parkinson's disease treatment
dopamine replacement drug
DOPA decarboxylase inhibitor (only in periphery)
Term
entacapone
Definition
Parkinson's disease treatment
dopamine replacement drug
COMT inhibitor (reduces breakdown of dopamine)
Term
bromocriptine
Definition
Parkinson's disease treatment
drug that mimics dopamine activity
D2 dopamine receptor agonist
Term
pergolide
Definition
Parkinson's disease treatment
drug that mimics dopamine activity
D1/D2 dopamine receptor agonist
Term
amantadine
Definition
Parkinson's disease treatment
antiviral
Term
deprenyl
Definition
Parkinson's disease treatment
MAOi
Term
benztropine
Definition
Parkinson's disease treatment
muscarinic acetylcholine receptor antagonist
Term
trihexyphenidyl
Definition
Parkinson's disease treatment
muscarinic acetylcholine receptor antagonist
Term
haloperidol
Definition
Huntington's disease treatment
dopamine antagonist
Term
baclofen
Definition
Huntington's disease treatment
GABAb agonist
Term
prednisolone
Definition
multiple sclerosis treatment
corticosteroid: decreases immune system antibody production and reduces myelin swelling and inflammation
Term
interferon beta
Definition
multiple sclerosis treatment
regulates immune system
Term
glatiramer acetate
Definition
multiple sclerosis treatment
first non-interferon, non-steroidal medication that effectively reduces new brain lesions.
Term
mitoxantrone
Definition
multiple sclerosis treatment
anticancer drug
suppresses activity of T cells, B cells, and macrophages that are thought to lead the attack on the myelin sheath.
Term
halothane
Definition
inhaled anesthetic
potent anesthetic, weak analgesic
Term
nitrous oxide
Definition
inhaled anesthetic
potent analgesic, weak anesthetic
Term
isoflurane
Definition
inhaled anesthetic
Term
enflurane
Definition
inhaled anesthetic
Term
dantrolene
Definition
neuromuscular blocker, blocks Ca channels, prevents hyperthermia
Term
thiopental
Definition
intravenous anesthetic
barbiturate
Term
etomidate
Definition
intravenous anesthetic
non barbiturate
Term
propofol
Definition
intravenous anesthetic
Term
ketamine
Definition
intravenous anesthetic
non bartituate
Term
lidocaine
Definition
local anesthetic
Term
tetracaine
Definition
local anesthetic
Term
prilocaine
Definition
local anesthetic
Term
bupivicaine
Definition
local anesthetic
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