Term
What can cause systolic CHF? |
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Definition
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Term
What type of CHF requires drug therapy? |
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Definition
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Term
Dopamine. Dobutamine Beta Blockers Pre/After |
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Definition
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Term
ACE Calcium Channel AT-2 Organic Nitrates Vasodilators Alpha 1 block (prazosin) Diuretics Nesiritide Pre/After |
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Definition
ACE- Both Calcium Channel- After AT-2-Both Organic Nitrates-After Vasodilators-Both Alpha 1 block (prazosin)After Diuretics-Pre Nesiritide-Both |
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Term
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Definition
diuretics ACE Beta Block Vasodilators Glycosides Nesiritide Inotropes |
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Term
Effects of atropine in heart: |
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Definition
Block ACH NE LIke Increase automaticity/CV |
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Term
In diseased patients what normally happens to ERP and CV |
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Definition
CV is usually slowed ERP is usually shortened |
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Term
Which type 1A drug causes less HOTN? |
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Definition
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Term
Which type of anti-arrythmic do you often need to give an anti-coagulant with? Why? |
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Definition
Often need to give with 1A drugs (quinidine) bc increase risk of emboli |
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Term
Which anti-arrythmic has "pro-arrythmic effects" and can be fatal. Name/Class |
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Definition
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Term
What are the mediators in autoregulation? |
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Definition
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Term
Type of angina nitrates are used to treat? |
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Definition
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Term
How do nitrates work? (primary/secondary effects) |
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Definition
1*preload reduction (decresaed demand) 2* Coronary artery dilation @ ischemic tissues--shunt O2 to ischemic 3*afterload reduction (decreased work) |
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Term
What are some systemic effects of organic nitrates? |
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Definition
HOTN (can cause baro-receptor release) |
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Term
Side effects of nitrates: |
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Definition
headache, HOTN, methemoglobinemia |
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Term
How does tolerance to nitrates develop? |
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Definition
Depletion of cysteine and SH groups Down regulation of ADH activity |
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Term
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Definition
Formation of S-nitrothiols from cysteine ADH forms NO Guanylate cyclase is stimulated by S-nitrothiols and NO This produces cGMP and increases CAMP |
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Term
What type of angina are beta blockers used for treating?? |
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Definition
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Term
Type of angina Calcium channel blockers are used for |
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Definition
Stable and Variant Stable: verapamil Variant: dihydropyridines |
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Term
Selectivity of tissues of calcium channel blockers: |
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Definition
Verapamil: AV>>Myo>>SM Diltiazem:SM>>Myo>>AV Nifedipine:SM>>Myo |
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Term
What is the MOA of ranolazine: primary and secondary |
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Definition
Blockade of late sodium channels (fix the impaired na/ca exchanger from ischemia) pFOX inhibitor (lipid metabolism of the heart for energy, decreases metabolic rate and thus O2 demand |
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