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PCOL I Exam 2 Drugs
Nicotinic Agonists & Antagonists, Adrenergic Agonists & Antagonists, VGCC Antagonists, Cholesterol Drugs
82
Pharmacology
Graduate
10/22/2012

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Term
varenicline
Definition
Chantix; partial nicotinic agonist
use: smoking cessation
Term
succinylcholine
Definition
depolarizing NMJ blocker; nicotinic agonsist
effect:: paralysis
use: surgery
contraindications: pseudocholinesterase deficiency (permanent paralysis) & malignant hyperthermia (muscle shivering causes dangerous rise in body T)
Term
vecuronium
Definition
nicotinic antagonist
effect: paralysis for surgery
Term
doxacurium
Definition
nicotinic antagonist
effect: paralysis for surgery
Term
cisatracurium
Definition
nicotinic antagonist
effect: paralysis for surgery
Term
rocuronium
Definition
nicotinic antagonist
effect: paralysis for surgery
Term
rapacuronium
Definition
nicotinic antagonist effect: paralysis for surgery; very selective for NMJ receptor
Term
mivacurium
Definition
nicotinic antagonist
effect: paralysis for surgery; releases histamine
very selective for NMJ receptor
short acting
Term
pancuronium
Definition
nicotinic antagonist
effect: paralysis for surgery
less selective for NMJ receptor
long acting
Term
dobutamine
Definition
beta-1 agonist
effect: positive inotropy > positive chronotropy
use: acute CHF
tachyphylaxis occurs; use for first few days
Term
acebutolol
Definition
beta-1 antagonist
(partial agonist)
Term
atenolol
Definition
beta-1 antagonist
Tenormin
Term
betaxolol
Definition
beta-1 antagonist
Term
bisoprolol
Definition
beta-1 antagonist
Term
metaprolol
Definition
beta-1 antagonist
Lopressor, Toprol XL
Term
esmolol
Definition
beta-1 antagonist
Brevibloc
IV, short acting
Term
albuterol
Definition
beta-2 agonist
Term
bitolterol
Definition
beta-2 agonist
Tornalate
Term
formoterol
Definition
beta-2 agonist
Foradil
Term
isoetharine
Definition
beta-2 agonist
Term
levalbuteral
Definition
beta-2 agonist
Xopenex
Term
metaproterenol
Definition
beta-2 agonist
Alupent
Term
pirbuterol
Definition
beta-2 agonist
Maxair
Term
salmeterol
Definition
beta-2 agonist
Serevent
Term
terbutaline
Definition
beta-2 agonist
Term
ritodrine
Definition
beta-2 agonist
IV
use: tocolytic
Term
isoproterenol
Definition
nonselective beta agonist
Term
roflumilast
Definition
phoshphodiesterase-4 inhibitor
Daliresp
use: COPD, asthma
Term
propranolol
Definition
nonselective beta antagonist
Term
nadolol
Definition
nonselective beta antagonist
Term
pindolol
Definition
nonselective beta antagonist
Term
sotalol
Definition
nonselective beta antagonist
Term
timolol
Definition
nonselective beta antagonist
Term
levobunalol
Definition
nonselective beta antagonist
Term
midodrine
Definition
alpha-1 agonist
Term
phenylephrine
Definition
alpha-1 agonist
eyedrop, tablet, IV, nasal spray
Term
pseudoephedrine
Definition
alpha-1 agonist
Sudafed
Term
oxymetazoline
Definition
alpha-1 agonist
Afrin
Term
prazosin
Definition
alpha-1 antagonist
Term
terazosin
Definition
alpha-1 antagonist
Hytrin
Term
doxazosin
Definition
alpha-1 antagonist
Cardura
Term
alfuzosin
Definition
alpha-1 antagonist
Uroxatral
Term
silodosin
Definition
alpha-1 antagonist
Rapaflo
Term
tamsulosin
Definition
alpha-1A selective antagonist
Flomax
Term
labetalol
Definition
alpha-1, beta-1, beta-2 antagonist
Term
carvedilol
Definition
alpha-1, beta-1, beta-2 antagonist
Coreg
Term
clonidine
Definition
alpha-2 agonist
Catapres
Term
methyldopa
Definition
alpha-2 agonist
Term
guanabenz
Definition
alpha-2 agonist
Term
guanfacine
Definition
alpha-2 agonist
Tenex
Term
dexmedetomidine
Definition
alpha-2 agonist
Term
brimonidine
Definition
alpha-2 agonist
Alphagan
Term
apraclonidine
Definition
alpha-2 agonist
Term
yohimbine
Definition
alpha-2 antagonist
Term
phentolamine
Definition
nonselective alpha antagonist
Term
phenoxybenzamine
Definition
nonselective alpha antagonist
Term
verapamil
Definition
nonDHP CCB
more negative inotropy than diltiazem
Term
diltiazem
Definition
nonDHP CCB
Term
amlodipine
Definition
DHP CCB
no first pass effect :)
Term
clevidipine
Definition
DHP CCB
Term
felodipine
Definition
DHP CCB
Term
isradipine
Definition
DHP CCB
Term
nicardipine
Definition
DHP CCB
Term
nifedipine
Definition
DHP CCB
Term
nimodipione
Definition
DHP CCB
Term
nisoldipine
Definition
DHP CCB
Term
pitavastatin
Definition
HMG CoA Reductase Inhibitor
Term
atorvastatin
Definition
HMG CoA Reductase Inhibitor
Term
rosuvastatin
Definition
HMG CoA Reductase Inhibitor
Term
pravastatin
Definition
HMG CoA Reductase Inhibitor
Term
simvastatin
Definition
HMG CoA Reductase Inhibitor
Term
fluvastatin
Definition
HMG CoA Reductase Inhibitor
Term
lovastatin
Definition
HMG CoA Reductase Inhibitor
Term
cholestyramine
Definition
Bile acid sequestrant
Term
colestipol
Definition
Bile acid sequestrant
Term
colesevalem
Definition
Bile acid sequestrant
Term
gemfibrozil
Definition
fibrate
Term
fenofibrate
Definition
fibrate
Term
niacin
Definition
effect: inhibit cAMP -> inhibit TG synthesis & lipolysis
Term
ezetimibe
Definition
cholesterol absorption inhibitor in smint
Term
CETP inhibitor
Definition
HDL cannot transfer to VLDL/LDL -> increase HDL
(future drug)
Term
PSCK9 inhibitor
Definition
LDL receptor cannot degrade -> more LDL receptors on surface -> decrease LDL
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