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PCC Pathophysiology Final
Bi 241 - Final
96
Biology
Undergraduate 2
12/12/2012

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Term
1-What is FEV1?
Definition
-one second expiratory volume
-it measures the max volume of air that can be expelled in one second
-if the bronchioled are narrowed then FEV1 decreases
Term
What is Vital Capacity?
Definition
the max volume of air that can be forcefully expelled after a maximum inspiration
Term
Explain the Pleural space!
Definition
-it is between the lungs and the chest wall

-has a negative pressure that is always less that the intrapulmonary pressure
Term
What is Pneumothroax? s/s?
Definition
-when air flows into the pleural space if the lung/chest is punctured

-results in a collapsed lung

-s/s: chest pain, SOB, air in pleural cavity tension pneumothorax
Term
What is Atelectasis? What are the two types
Definition
-an incomplete expansion of the lung or a collapse of part of the lung

1-obstructive
2-compression
Term
What is the #1 reason people get atelectasis?
Definition
post op pain = not breathing fully to circulate air
Term
What is SARS?
Definition
-severe acute respiratory syndrome
-no effective drug to treat it
-transmitted from person to person via droplets
Term
TB! What are the s/s of TB? What are the TX for it?
Definition
-Is very resistant to drugs because of waxy/fatty capsule
-s/s: granulomas
-dx include skin test, chest xray and sputum sample
Term
Explain Pulmonary Emphysema
Definition
-inflammation and narrowing of terminal bronchioles
-dialation of pulmonary air apaces
-decrease in lung capacity

-s/s: dyspnea, cyanosis, SOB
Term
What is Cyanosis?
Definition
a blue tinge of skin and mucous membranes from an excessive amount of reduced Hb in the blood
Term
What is pulmonary fibrosis?
Definition
- fibrous thickening of the avelolar speta which leased to the lungs becoming ridgid
Term
What is a fibroadenoma?
Definition
-a benign fibrous tissue formation in the breast
-needs to be removed because it keeps growing
-seen usually in young women
-"bleeding nipples"
Term
What are the risk factors for breast carcinoma?
Definition
-no pregnancy
-early first period
-late menopause
-family Hx
Term
Which is better, having a tumor that is estrogen receptor positive or negative? why?
Definition
-better outcome with estrogen receptor positive results because then the drug that is used to eat up all the extra estrogen is effective = better prognosis
Term
Which increases your chances of developing breast carcinoma more: estrogen or estrogen & progestin?
Definition
estrogen and progestin because it increases the density of breast tissue and increases the risk of cancer
Term
Explain the BRCA 1 & 2 gene, what are the stats?
Definition
BRCA1- increases risk of breast and ovarian cancer greatly

BRCA2 - increases breast but less in ovaries
Term
What are the functions of the liver?
Definition
-metabolism
-synthesis of plasma proteins and blood clotting proteins
-storage of vitabin B12
-detox and excretion of substances
Term
What are the three types of liver injury?
Definition
-Hepatitis
-viral hepatitis
-alcoholic hepatitis
Term
Describe Hepatitis A!
Definition
-virus secreted in throat/nose and still
-person to person contact
-fecal contamination of food
-self limiting with no carriers/liver disease
-immunization available
Term
Describe Hepatitis B!
Definition
-blood of bodily fluids
-immunization available
-10% become carriers
-maybe develop chronic liver disease
Term
Describe Hepatitis C!
Definition
-blood and bodily fluid tx
-75% become carriers and many develop chronic liver disease
-no prevention after or before exposure
Term
What happens when you give children asprin?
Definition
-Reye's syndrome
-increases fat deposits in liver which leads to hepatic encephalopathy and neurological dysfunction
Term
What is Cholelithiasis?
Definition
-aka gallstones
-inflammation of the gall bladder
-4 f's: female, fertile, fat and fair
-increases with birth control
Term
What are the three causes of jaundice?
Definition
1-hemolytic = increase in breakdown of bile

2- hepatocellular = damage leads to decrease in billirubin conjugation

3- obstructive = prevents bile from getting to the duodenum
Term
What are the three different cells of the pancreas and what do they secrete?
Definition
-Alpha: glucagon
-Beta: insulin
-Delta: somatostatin (suppresses insulin/glucagon)
Term
What causes Acute Pancreatitis?
Definition
1- obstruction of pancreatic duct
2-alcohol
3- cholesterol and drugs

s/s: pain, ill and high mortality rate
Term
What is Cystic Fibrosis?
Definition
-genetic disease that results in a defective transfer of Cl, NA and water acrosss the cell membrane
-because of this lung secretions become very thick and get pneumonia and also blocks pancreatic duct
-sweat test
-very serious 50% die by 32
Term
What are the two types of Diabetes?
Definition
DM1: insulin deficient, juvenile diabetes, results from damage to inslets

DM2:adult onset, caused by inadequate response to insulin
Term
What is Diabetic Ketosis?
Definition
-when the body starts digesting other carbs

-high in type 2
-low in type 1
Term
What are the causes of hyperglycemia?
Definition
- DM
-pancreative disease
-endocrine deficiencies
-drugs
-hereditary disease
Term
What can cause a person to be hypoglycemic?
Definition
-exercise
-skipping meals
Term
What does the Adrenal Medulla reclease?
Definition
-epinephrine -stimulated by SNS-
-which increases blood glucose
Term
What are the functions of Insulin?
Definition
-promotes entrance of glucose into the cells
-favors glucose as a source of energy
-promotes storage of glucagon
-favors production of glucose into fat
-promotes entry of AA's into cells
-stimulates protein synthesis
Term
What does the anterior lobe of the pituitaty glad release?
Definition
-Growth Hormone
-Prolactin
-adrenocorticotrophic hormone (ACTH)
-FSH
-LH
Term
What does the posteriod lobe of the pituitary release?
Definition
-ADH
-Oxytocin
Term
What is diabetes insipidus?
Definition
-when the posterior lobe produces no ADH
-results in no water reabsorption and a dilute urine
Term
What is the result of GH overproduction?
Definition
adults: acromegaly
children: gigantism
Term
What is Goiter?
Definition
-caused by an increase in Thyroid Hormone
-enlarged thyroid gland
-tx: radioactive iodine or surgery
-also called Grave's disease which is an autoimmune disorder

-A goiter that does not secrete excess thyroid hormone is called a nontoxic goiter.
Term
What is hypothyroidism called in adults? children?
Definition
adults = myxedema
children = cretinism
Term
What are the different types of Thyroid Tumors?
Definition
well differentiated = 90% of the time
undifferentiated & medullary = very severe
Term
What does the parathyroid do?
Definition
-regulates the calcium leves
-a decrease in Ca leads to tetany
-increase leads to decrease in neuromuscular excitability
Term
Explain the Adrenal Cortex!
Definition
-disturbances of the glad result in abnormalities in metabolism of carbs & protein
-Hormones that it makes:
*Glucocorticosteroids
*Mineralcorticosteriods (Aldesterone)
* Sex hormones
-Sugar, Salt & Sex-
Term
What is Addison's disease?
Definition
-an adrenal hypofunction
-leads to deficient in all steroid hormones and results in hyperpigmentation
Term
What is Cushing's disease?
Definition
-results in microadenoma in the pituitary
-high levels of ACTH & cortilsol
-excessive production of adrenal corticosteriods can be caused by:
*hormoneproducing pituitary hormone
*hormone producing adrenal tumor
*given large amounts of hormone
Term
Explain the Adrenal Medulla:
Definition
-produces catacholamines that stimulate the sympathetic nervous system
*nonephrine
* epinephrine
* any emotional stress
Term
What is a pheochromocytoma?
Definition
-tumor in the adrenal medulla that results in an increase in BP, Pulse and # of catacholamines produced
Term
What is somatitis?
Definition
innflammation of the oral cavity
Term
What are the two types of cardiac spinchter dysfunction?
Definition
1- cardiospasm (fails to open properly)
2- incompetent cardiac spincter (inability to remain closed)
Term
What causes acute gastritis?
Definition
-it is inflammation of the stomach
1-NSAIDS
2-Alcohol
Term
What causes chronic gastritis?
Definition
-H. Pylori cause it
-the ammonia produced by the bacteria damages the gastric mucosa
Term
What is Chron's disease?
Definition
-usually in the small bowel
-a type of chronic enteritis
Term
What are the three types of inflammatory intestine disease?
Definition
1-antiobiotic accociated colitis
2-appendicitis
3-mekles diverticulum
Term
What is Ulceritive colitis?
Definition
-inflammation of colon/rectum
-tends to lead to colon carcinoma
Term
What is Diverticulitis?
Definition
-inflammation whenthe outpouching of the colon mucosa gets trapped
-chronic constipation and low residue diets tend to lead to this
-tx: high fiber and regular soft BM's
Term
What is an adhesion?
Definition
twisting with the bowel and the omentum
Term
Hernia:
Definition
bowel outpouches through the abdonimal wall
Term
What are the three types of hernia?
Definition
1-incarcirated:stuck and cant be pushed back in
2-reducable: can be pushed back in
3-strangulated: no blood flow is getting to the bowel and starts to die
Term
what is Intasusseption
Definition
when the bowel pushes itself into the bowel
Term
What is a volvulus?
Definition
when the bowl twists around its self and leads to reduced blood supply
Term
What is Salpingitis?
Definition
PID - pelvic inflammatory disease-
inflammation of the fallopian tubes and along the ovaries, usually caused by STI infection
-predisposes the female to ectopic pregnancies
Term
What is Cervical dysplasia?
Definition
-when the tissue at the end of the cervix does not mature right and can change into cancer
1-mild=results from inflammation
2-sevear= in situ carcinoma that leads to invasive carcinoma

tx: removal of carcinoma
Term
What are the causes of Irregular Uterine bleeding?
Definition
-dysfunctional uterine bleeding from failure to ovulate
-benign endometrial hyperplasia
-endometrial or cervical polyps
-uterine myomas
-uterine carcinoma
-painful menstrations
Term
What is Dysmenorrhea?
Definition
-painful menstruation
1-primary= normal organs
2- secondary = diseased organs or endometriosis
Term
What is TSS?
Definition
toxic shock syndrome
caused by staphlococcus bacteria that release toxins into the body
no cure, just remove tampon to decrease the toxin concentration
Term
What does the placenta produce?
Definition
-HPL
-HCG
Term
What is Placenta previa?
Definition
when the placenta attaches lower than normal
Term
What does an ACE inhibitor do?
Definition
reduces the level of Angiotension 2 levels resulting in a decrease in blood pressure
Term
What is Glomerulophritis?
Definition
innflammation of the glomeruli via Ag/Ab reaction and results in kidney injury/destroyed which leads to kidney failure
Term
What is Arteriolar Nephrosclerosis?
Definition
-caused by high BP
-narrowing of the tubules and a decrease in blood flow into the kidney
-results in kidney failure/death
Term
What is the pathology of kidney stones?
Definition
when Calcium salts (hyperparathyroidism) or uric acid (Gout) or infections get stuck in the pelvis of the kidney and block the output
Term
What are the s/s of Kidney Failure?
Definition
-Uremia = build up of toxins
-weakness
-decreased apetite
-nausea
-vomiting
-anemia
-hypertension
-rentention of salt and water
-tx: dialysis or transplant
Term
What is BPH?
Definition
Benign Prostatic Hypertropy
-usually happens in older men
-obstructs the urine flow
-tx: transurethral rescetion cures the blockage
Term
What is cryptochiaiasm?
Definition
-WHen the testes do not descend properly.
-results in no sperm production because of the increase in temp
-also increases chances of malignancy and should be removed
Term
What is an electrolyte?
Definition
a compound that in a solution dissolves into positive and negative ions
Term
What is Metabolic acidosis?
Definition
-results in excess enderogenous acid that depletes the bicarbonate

-usually caused by renal failure (Ketosis and overproduction of lactic acid)
Term
What is respiratory acidosis?
Definition
-results in inefficient excretion of carbon dioxide by the lungs
-caused by chronic pulmonary diseases
Term
What is metabolic alkalosis?
Definition
-is excess plasma bicarbonate
-caused by a decrease in gastric juices
-a decrease in Cl-
-excess corticosteroid
-or ingestion of too much bicarb/antacids
Term
What is a stroke?
Definition
-any injury to the brain caused by disturbances of its blood supply
Term
What is a TIA?
Definition
-transient ischemis attack
-a temporary cerebral dysfunction as a result of an obstruction of a cerebral vessel by a bit of artheromatous debris or a blood clot
Term
What does bone require to grow
Definition
calcium
vitamin d
phosphate
Term
What is Gout?
Definition
a syndrome associated with an increase in uric acid in the blood/bodily fluids
-leads to a precipitation of urice acid into sodium urate crystals in the joints and other tissues
-results in join pain arthritis and spreads to kidneys and urinary tract
Term
Does an intraductal carcinoma of the breast have a very favorable prognosis?
Definition
YES
Term
What are the features of pulmonary emphysema?
Definition
Nonuniform ventilation of alveoli reduces the efficiency of ventilation.

Chronic inflammation of bronchioles leads to trapping of air in the lungs.

A loss of lung elasticity requires active expiratory effort.

Enlargement of air spaces and reduction of capillary surface area within the lungs reduces the efficiency of gas exchange.
Term
Which hormone or combination of hormones used for treatment of menopausal symptoms presents the greatest risk for breast cancer?
Definition
estrogen & progestin
Term
What is a Hydrocele?
Definition
-fluid filled sac in the tunica vaginalis of the scrotum
-Hydrocele is an acutely painful condition that is usually associated with severe symptoms and must be surgically treated as quickly as possible.
Term
What is a varocele?
Definition
-dialated spermatic cord
-cause discomfort and may eventually lead to impotence.
Term
what is a laparoscope primarily used for?
Definition
Visualize the ectopic deposits within the pelvis
Term
Chrones disease is ?
Definition
chronic inflammation and ulceration of the distal ileum
Term
In diabetes, when excessive ketones are formed it results in...?
Definition
Metabolic acidosis
Term
Hypervention and a fall in PCO2 results in...?
Definition
Respiratory alkalosis
Term
Impaired lung function from COPD results in....?
Definition
Respirartory acidosis
Term
Kidney failure and the retention of nonvolatile acids results in...
Definition
Respirartory acidosis
Term
Excess adrenal corticosteroids results in...?
Definition
Metabolic alkalosis
Term
T/F:
Episodes of severe hypoglycemia can sometimes be the result of beta cells that give rise to insulin-secreting tumors
Definition
true
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