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PC 2 lab values
lab values
120
Pharmacology
Professional
08/22/2012

Additional Pharmacology Flashcards

 


 

Cards

Term
RBC male
Definition
4-6 x 10^6 cell/ uL 
Term
RBC fem. 
Definition
4-5 x10^6 cell/ uL
Term
Hgb male
Definition
14-18 g/dL
Term
Hgb fem. 
Definition
12-15 g/dL
Term
Hct fem
Definition
35-45% 
Term
Htc male
Definition
40-50%
Term
MCV
Definition
80-90 fL/cell
Term
MCH
Definition
27-33 pg/cell
Term

MCHC

 

Definition
33.5- 35.5 g/dL
Term

Retic.

 

Definition
.5-2.5 %
Term
RDW
Definition
11.5-14.5 %
Term
WBC
Definition
4.4-11.4 x 10^3 cells/uL
Term
Plt.
Definition
140-440x10^3 cells/uL
Term
MPV
Definition
7-10 fL 
Term
PT
Definition
10-13 sec
Term

INR

 

Definition
.9-1.1 sec
Term
aPTT
Definition
21-45 sec 
Term
Fibrinogen 
Definition
200-400 mg/dL
Term
FDP
Definition
2-7 ug/mL
Term
D-Dimer 
Definition
.2-.5 ug/mL
Term

mean corpuscular Hgb def.

 

Definition
hemoglobin/hematocrit 
Term
rbc distribution width def.
Definition
indication of variation of rbc size 
Term
reticuloxyte count def. 
Definition
immature rbc's 
Term
macrocytic 
Definition
MCV > or equal to 100 fL
Term
normocytic/normochronic
Definition
mcv 81-99 fL
Term
microcytic 
Definition
mcv < or equal to 80 fL
Term
causes for macrocytic
Definition
vit b12 def, folic acid def. 
Term
causes for normocytic
Definition
acute blood loss, hemolysis
Term
causes for microcytic
Definition
 iron def. 
Term
Na
Definition
136-146 mEq/L
Term
K
Definition
3.5-5 mEq/L
Term
Cl
Definition
96-106 mEq/L
Term
BUN: Scr Ratio 
Definition
indicates fluid status; if >20 = dehydration
Term
FENa
Definition
if FENa< 1% = dehydration
Term

hyponaturemia signs 

 

Definition

nausea

malaise

headache

altered mental status

depressed deep tendon reflexes

lethargy

seizures 

( HANDS LM)

Term
isovolemic hyponatremia common cause 
Definition
syndrome of inappropriate ADH hormone SIADH 
Term
drugs that increase SIADH risk
Definition

chlorapromide

oxyabazeine

carbamazepine

( all increase ADH release and increase response to ADH)

Term

hypernatiremia can cause 

 

Definition

diabetes insipidus which can be of 2 classifications: 

central - sudden onset polyuria 

nephrogenic - lithmus onset polyuria 

Term
hypokalemia (apparent cause)
Definition

beta agonists 

insulin 

metabolic alkalosis 

(BIM)

Term
hypokalemia (true) causes
Definition

Gi loss

renal loss 

decreased intake

 

renal loss includes: diuretics 

hyperaldosteronism 

amphotericin B 

corticosteroids 

Term
hyperkalemia  (apparent) cause
Definition
metabolic acidosis 
Term
hyperkalemia ( true) cause 
Definition

increased intake : cellular/muscle breakdown

 salt substitutes

 

decreased output : renal failure, 

ACE-I

ARB ( angiotensin receptor blocker) 

beta blockers

trimetoprim 

Term
Mg
Definition
1.5-2.2 mEq/L
Term
Ca
Definition
8.5-10.8 mg/dL
Term
Phos 
Definition
2.6-4.6 mg/dL 
Term
Calcium Phosphate Product 
Definition
if > 55 = increased risk for soft tissue calcification
Term
hypomagnesim causes
Definition

alcoholism - poor nutrient intake

diuretics

amphotericin B 

vomiting

diarrhea 

hypoparathyroidism

hyperaldosteronism

hyperthyroididsm 

Term
hypomagnesium signs /symptoms
Definition

muscle twitch

tetany

personality changes

convulsions

stupor

coma 

torsades de pointes 

Term
hypermagnesium cause
Definition

antacid

laxative 

iv fluids/ parenteral nutrition 

Term
hypermangesium symtoms
Definition

muscle weakness

fatigue 

lethargy

hypotension

coma 

paralysis

cardiac arrest 

Term
hypocalcemia causes
Definition

long term TPN 

hypoparathyroidism ( thyroidectomy)

renal failure

 

Term
meds that can cause hypocalcemia
Definition

meds: steroids

bisphosphonates

diuretics 

Term
hypocalcemia signs/ symptoms
Definition

finger numbness

tingling in extremities

paresthesia

tetany 

chvostek's sign

trousseau's 

hypotension 

cardiac arrhythmias 

Term
hypercalcemia causes
Definition

malignancy

primary hyperparathyroidism

 

Term
meds that can cause hypocalcemia
Definition

calcium supplementation

vit D analogue

estrogen

thiazide diuretics 

Term
signs / symptoms of hypercalcemia
Definition

nause 

vomiting 

abdominal pain

polyuria

polydipsia

ekg changes

ventricular arrhythmias

lethargy 

obtundation

pscyhosis 

coma

death

Term
hypophosphatemia causes
Definition

alcoholism

thiazide/ loop diuretics 

intracellular shifiting - refeeding syndrome 

excessive use of phosphate binders: calcium containing antacids, sevelamer , lanthanum 

Term
signs/symptoms of hypophosphatemia
Definition

muscle wekaness 

paresthesia

confusion

obtundation

seizure 

coma 

Term
hyperphosphatemia causes
Definition

chronic kidney disease

excessive intake

hyperparathyroidism

treatment of malignancy

Term
sings/symptoms of hyperphosphatemia
Definition
soft tissue calcification
Term
TnT normal
Definition
<.1 ng/mL
Term
myoglobin
Definition

early detection

 

Term
troponins
Definition
best for late detection
Term
CK-MB
Definition

used to diagnose AMI

can use by itsel (serial)

Term
meds that can increase CK
Definition

amphotericin B

Clofibrate

ethanol

lithium

halothane

succinylocholine

barbituate poising 

im injections

aminocapronic acid

3 hydroxy 3 methylglutaryl coenzyme A reductase inhibitors

Statins

working out 

Term
RI
Definition
> 2 = MI
Term
cholesterol
Definition

< 200 mg/dL

borderline high 200-239

high >240 

Term

hematocrit

Definition
% of vol that are erythrocytes
Term
mean cell vol.
Definition
average number of rbc's
Term
mean corpuscular Hgb
Definition
amount of hemoglobin PER RBC ( HgB/RBC)
Term
hypochromic
Definition
low MCH (mean corpuscular HgB) - pale RBC- iron deficiency anemia
Term
mean corpuscular hemoglobin conc.
Definition
Hgb/hematocrit 
Term
polycythemia
Definition

high rbc's / HgB

 disease state in which the proportion of blood volume that is occupied by red blood cells increases. Blood volume proportions can be measured as hematocrit level.

 

Term
leukopenia
Definition
low wbc
Term
leukocytosis
Definition
high wbc
Term
what does anemia assess?
Definition
rbc volume - MCV - mean cell volume ( average number of rbc's)
Term
what is normocytic anemia
Definition

occurs when the overall hemoglobin levels are decreased, but the red blood cell size (mean corpuscular volume) remains normal

MCV 81-99 fL. 

Term
what is macrocytic anemia
Definition
In a macrocytic anemia the larger red cells are always associated with insufficient numbers of cells and often also insufficient hemoglobin content per cell
Term
thrombocytosis /thrombocythemia 
Definition
high platelets 
Term
mean platelet vol
Definition
measurement of avg. size of platelets
Term
prothrombin time 
Definition
amount of time it takes 4 blood to clot 
Term
D dimer
Definition

D-dimer is a fibrin degradation product a small protein fragment present in the blood after a blood clot is degraded by fibrinolysis. It is so named because it contains two crosslinked D fragments of the fibrinogen protein.[1]

D-dimer concentration may be determined by a blood test to help diagnose thrombosis.

Term
incrased fibrinogen and increased fibrin degredation indicate
Definition
disseminated intravascular coagulation- In DIC, the processes of coagulation and fibrinolysis are dysregulated, and the result is widespread clotting with resultant bleeding.
Term
neutrophils
Definition

45-73%

 

or 45-70%

Term
bands 
Definition
3-5%
Term
lymph
Definition
20-40%
Term
mono
Definition
2-8
Term
eosin
Definition
0-4%
Term
baso
Definition
0-1%
Term

neutrophils are the ___ response to infection

less mature neutrophils are called ___and are ___ in infections

bands are ___ neutrophils

 

Definition

first

bands / stab; elevated

immature

Term
granulocyte
Definition
leukocytes tat engulf/digest other cells
Term
lymphocyte 
Definition
recognize non self cells that alert NK, T, B, cells (lymph NKTB < like new kids on the block) 
Term
lymphopenia causes
Definition

HIV type 1

radiation exposure

glucocorticosteroids

lymphoma (hodgkin's disease)-  a cancer of lymph tissue found in the lymph nodes, spleen, liver, bone marrow, and other sites.

aplastic anemia - condition where bone marrow dosn't make sufficient new cells to replace old ones

Term
lymphocytosis causes
Definition

viral infection

lymphomas 

Term
left shift
Definition
increase in number of neutrophil cells ( due to infection usually and if u have left shift then your bands increase and all your other cells will decrease) 
Term
bandemia
Definition
high band cell count; usually due to infection >5%
Term
normal reporting order of differential
Definition

segs/ bands/ lymph/mono/ eosino/ baso

"some bands like mooning every babe"

Term
sterile body sites
Definition

bloodstream

cerebrospinal fluid

pericardinal fluid

pleural fluid

peritoneal fluid- lubricates abdominal cavity

synovial fluid - in synovial joints

bone

urine (directly from kidney/bladder)

Term
skin normal flora
Definition

staphlococcus

streptococcus

corynebactrum

Term
respiratory normal flora
Definition

streptococcus 

haemophilus 

Term
GI tract normal flora
Definition

bacteroide

escherichia 

klebsiella pneumonia

enterococcus

streptococci 

Term
genital normal flora
Definition

streptococcus

staphlococcus

lactobacillus

 

Term
common stains to ID fungi
Definition

KOH

India ink

periodic acid schiff

gomori methenamine silver stain

acid fast

gram stain

wright or giemsa stain

Term
ppd
Definition
purifeid protein derivative - inect into skin and ppl that have been exposed to hiv will have a hypersenstitivity rxn to it 
Term
tests done to diagnose hiv
Definition
elisa (EIA) and western blot to confirm 
Term
Scr
Definition
.7-1.4 mg/dL
Term
BUN
Definition
8-20 mg/dL
Term
cockcroft gault equation
Definition

((140-age)x weight)/ 72x Scr

and x .85 if female

Term
Ideal body weight 
Definition

male is 50+2.3(in over 5 ft.)

female is 45.5 +2.3(in over 5 ft)

Term
adjusted body weight 
Definition

IBW+.4(actual - IBW)

use adjusted body weight when actual is >120 % of IBW

actual/ibw x100 

Term

BUN:Scr ratio of > 20:1 means...

if between 10 - 20 means...

Definition

dehydration; volume depletion- pre renal

intrinsic kidney damage 

Term
what do you use to estimate GFR? 
Definition
MDRD- modification of diet in renal disease
Term
rbc's in urince could mean...
Definition

glomerulonephritis (kidney filter function is damaged)

infection

renal infarction

papillary necrosis

tumors

stones

coagulopathies 

Term
wbc's in urine could mean
Definition

uti

glomerulonephritis

intersitial nephritis ( inflammatory conditions)

Term

protein in urine could mean...

 

Definition
kidney damage 
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