Term
| The Renin-angiotensin system (RAS) is involved in what physiological fxns? |
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Definition
1. Major effects: Maintains blood pressure, salt, and water balance
2. Has many other actions ranging from vasoconstriction of vessels to a role in inflamation.
*It is composed of a systemic and local system
*Involved in short and long-term regulation of BP |
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Term
| The only precursor of the RAS is? |
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Definition
Angiotensinogen
1. It is the rate limiting factor in the activity of the systemic renin angiotensin system. |
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Term
| Where is Angiotensinogen produced? |
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Definition
a.) primarily from hepatocytes
- for systemic derived RAS
b.) This pro-hormone also is synthesized in the CNS, heart, vasculature, kidney and adipocyte (fat) cells. |
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Term
Adipose tissue angiotensinogen mRNA is upregulated by __________.
Hepatocyte angiotensinogen mRNA is upregulated by ____________. |
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Definition
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Term
| Which enzyme cleaves Angiotensinogen to form the decapeptide AngI? |
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Definition
Renin
(occurs in circulation) |
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Term
| What can stimulate the release of Angiotensinogen? |
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Definition
Inflammation and Angiotensin II
*Ang II exerts a positive feedback regulation via an AT1 receptor. |
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Term
| A highly substrate- and species- specific aspartyl enzyme that catalyzes the rate limiting-step in a cascade that results in the formation of angiotensin II and its congeners. |
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Definition
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Term
| Where is Renin synthesized |
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Definition
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