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Pathophysiology
Exam 4 Chapter 39 Prostate Cancer
20
Pathology
Undergraduate 1
06/13/2014

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Term
What predisposes men to cancer of prostate (is there a higher risk factor with race?),
Definition
-Age >65, heredity, hormones, environment, high fat diet.
-ethnicity -Race (African American Men)
Term
Describe screening tools for prostate cancer
Definition
-PSA is a glycoprotein secreted into the cytoplasm of benign and malignant prostatic cells
-Annual screening and digital exam over 40-50
Term
What is a Gleason score?
Definition
-Diagnosis-transrectal ultrasound; -Gleason grading system-well differentiated Grade 1 to poorly differentiated Grade 5
-Watchful waiting based on tumor grade, age/health
Term
Cause of Erectile Dysfunction (ED)
Definition
Aging,
Phychosocial problems-
depression,
esteem issues,
partner relationships,
substance abuse,
anxiety,
fear of performance failure.

Drugs: antidepressant, antipsychotic, antihypertensive.
Excessive alcohol and aging.
Term
Erectile Dysfunction ED

What diseases cause arterial insufficiency in ED
Definition
hypertension,
hyperlipidemia,
Vascular disease
cigarette smoking,
DM,
pelvic irradiation.
Term
What is role of cGMP treatment for ED?
Definition
Viagra, Cialis are Selective inhibitor of phosphodiesterease type 5, the enzyme that inactivates cGMP, alpha adrenergic receptor antagonists, prostaglandin analog.
Term
What predisposes a patient to cancer of the testes?
Definition
Strong association with cryptoorchidism or undescended testes, higher location greater the risk; genetics important as well, disorder of testicular development.
Term
Testicular torsion
Definition
Twisting of spermatic cord that suspends the testis; most common acute scrotal disorder in pediatric and young adult population
Term
Testicular torsion-why does this have more urgency for detection and treatment?
Definition
It's a true surgical emergency and early detection and treatment are necessary if the testicle is to be saved.
Term
Cause of urinary retention in older male-what is the disease?
Definition
BPH =Benign Prostatic Hyperplasia a disorder of the prostate.
Term
Priapism, what is it,
Definition
Involuntary, prolonged, abnormal, painful erection 4-6 hrs
Term
Priapism, what causes it,
Definition
Sickle Cell and neoplasm. Deoxygenation and stasis of cavernosal blood during erection is thought to increase sickling.
Term
What patient population is at high risk for Priapism?
Definition
Any age and newborns and any age group, but highest risk is boys 5-10 years of age.
Term
Priapsim is a failure of __________
Definition
hypoxia of local tissue, impaired blood flow in the corpora cavernosa of the penis.
Term
Nurses role in vasectomy-patient education
Definition
fertility continues for 4-5 weeks after vasectomy
Term
BPH: cause,
Definition
unknown
Strong association with cryptoorchidism or undescended testes, higher location greater the risk; genetics important as well
Term
BPH: symptoms,
Definition
Seven questions rated 0-7(7 most severe)
-Incomplete emptying,
-Frequency,
-Intermittency,
-Urgency,
-Weak steam,
-Straining,
-Nocturia
Term
BPH: what determines when treatment occurs?
Definition
-Mild symptoms; watch & wait.
-Server signs of obstruction=surgery.
-TURP transurethral resection of prostate.
-Provide comfort and avoid serious renal damage.
Term
Cryptorchidism
Definition
failure of testes to descend.
–Incidence related to birth weight and gestational age
–Undescended testes, exposes testes to higher temperature.
–Spontaneous descent often occurs during 3-6 months
–Consequences infertility, malignancy and psychological effects
Term
What is role of nitric oxide in ED?
Definition
Signals to surrounding muscles to relax and increase blood blow and stay erect.
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