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Pathophysiology
Ch. 1 - Fundamentals
48
Nursing
Undergraduate 2
06/11/2011

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Term
homeostasis
Definition

when the body maintains a dynamic, steady state of internal balance; when homeostasis is disrupted by an external stressor (injury, lack of nutrients, invasion by parasite, etc.) illness may occur.

Term
medulla oblongata
Definition
part of the brain stem associated with vital functions (respiration, circulation, gag reflex, body temp, and other essentials to life)
Term
pituitary gland
Definition

regulates growth, maturation, and reproduction (essential hormones)

Term
reticular formation
Definition
network of nerve cells and fibers in the brain stem and spinal cord that help control vital reflexes (cardiovascular function and respiration)
Term
positive feedback
Definition

moves the body further away from homeostasis

ex. labor (muscle contraction is not normal homeostatic state bud during labor muscle contraction is necessary)

Term
negative feedback
Definition

works to restore homeostasis

ex. increased insulin production in response to hyperglycemia

Term
disease
Definition

occurs when homeostasis is not maintained; doesn't mean you are always ill

ex. coronary artery disease, asthma, hypertension

Term
illness
Definition

occurs when a person is no longer in a state of "normal health" 

ex. subjective symptoms that may indicate the presence of disease

Term
pathogenesis
Definition

a disease's development; most progress according to a typical patter of symptoms

self-limiting: require little intervention or treatment

chronic: require constant attention to maintain long periods of remission

Term
exposure/injury
Definition
1st stage of disease; target tissue is exposed/injured
Term
latent/incubation
Definition
2nd stage of disease; no signs or symptoms are evident; might not feel good but nothing is necessarily wrong
Term
prodromal
Definition
3rd stage of disease; signs and symptoms are mild and non-specific; important to start testing for the obvious and rule things out
Term
acute
Definition
4th stage of disease; disease reaches its full intensity, patient is not always incapacitated; elderly people, infants, people with disease or illness are more susceptible 
Term
remission
Definition
5th stage of disease; no signs are symptoms are present anymore; the disease itself is still present, but no illness is present
Term
convalescence
Definition
6th stage of disease; disease is terminated (totally gone), patient gets stronger/better
Term
recovery
Definition
7th and final stage of disease; patient returns to optimal health status (which might not be back to where the patient was before the disease)
Term
cytoplasm
Definition
surrounds cell components; gel-like
Term
mitochondria
Definition
produce ATP; site of cellular respiration; type of organelle suspended in the cytoplasm
Term
ribososomes
Definition
site of protein synthesis; type of organelle suspended in the cytoplasm
Term
endoplasmic reticulum
Definition

membrane enclosed tubules; type of organelle suspended in the cytoplasm; 2 types:

rough - covered in ribosomes

smooth - participate in lipid synthesis

Term
golgi apparatus
Definition
synthesize carbohydrate molecules that eventually become lipoproteins, glycoprotiens, and enzymes; type of organelle suspended in the cytoplasm
Term
lysosomes
Definition
digestive bodies; participate in phagocytosis; type of organelle suspended in the cytoplasm
Term
peroxisomes
Definition
reduce oxygen to hydrogen peroxide and hydrogen peroxide water; type of organelle suspended in the cytoplasm
Term
cytoskeletal elements
Definition
help maintain the cells shape; type of organelle suspended in the cytoplasm
Term
centrosomes
Definition
take part in cell division; type of organelle suspended in the cytoplasm
Term
microfilaments
Definition
participate in transportation and cell division; type of organelle suspended in the cytoplasm
Term
nucleus
Definition
the cell's control center, "brain", "boss", etc.; participates in cell growth, metabolism, and reproduction; RNA synthesis and DNA storage both occur here 
Term
cell membrane
Definition
cells external boundary; semipermeable (lets things into and out of the cell)
Term
mitosis
Definition
type of orderly cell division that leads to tissue growth; consists of 9 steps
Term
cancer
Definition
un-orderly division of the cell
Term
epithelial
Definition
cell type; line the body's internal (blood vessels, internal organs, etc.) and external structures (skin)
Term
connective
Definition
cell type; found in the skin, bones, joints, artery walls, fascia, nerves, and body fat (sometimes blood); tougher than epithelial cells
Term
nerve
Definition
cell type; consists of neurons and neuroglial cells
Term
muscle
Definition
cell type; consists of skeletal, smooth, and cardiac
Term
atrophy
Definition
reduction in size; can be homeostatic or pathogenic
Term
hypertrophy
Definition
increase in size; can be homeostatic or pathogenic; ex. pregnancy
Term
hyperplasia
Definition
increase in the number of cells; mainly abnormal; ex. skin cancer
Term
metaplasia
Definition
replacement of one cell type with another; matastisis
Term
dysplasia
Definition
abnormal differentiation of dividing cells; how mature/immature a cell is
Term
apoptosis
Definition
normal cell death; genetically programmed; certain cells live "x" number of days
Term
liquefaction necrosis
Definition
a lytic enzyme dissolves (or liquefy) necrotic cells; type of cell death
Term
caseous necrosis
Definition
cellular pieces remain undigested for months to years; type of cell death; ex. golf ball sized lump in the lung that looks like cottage cheese that is commonly found in TB patients
Term
fat necrosis
Definition
lipases breakdown triglycerides into free fatty acids that form soaps; type of cell death
Term
coagulative necrosis
Definition
type of cell death that occurs when blood supply is interrupted
Term
dry gangrenous necrosis
Definition
minimal bacterial invasion; type of cell death
Term
moist gangrenous necrosis
Definition
develops along with liquefaction necrosis; type of cell death
Term
gas gangrenous necrosis
Definition
develops with infection from clostridium; type of cell death; directly related to the bacterium Clostridium
Term
self-regulating feedback mechanism
Definition

sensor: detects disruptions in homeostasis

control center: receives signals from the sensor and initiates the effectors' response

effectors: act to restore homeostasis

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