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Pathophysiology
Ch. 2 - Cancer
28
Nursing
Undergraduate 2
06/11/2011

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Cards

Term
cancer
Definition
also known as malignant neoplasia; group of more than 100 diseases characterized by DNA damage that causes abnormal cell growth and development
Term
initiation
Definition
1st step in cancer development; damage to DNA and it's resulting mutation
Term
promotion
Definition
2nd step in cancer development; mutated cell is exposed to growth factors
Term
progression
Definition
3rd step in cancer development; tumor continues to mutate and metastasizes
Term
proto-oncogenes
Definition
1st control; identifies mutation and rids of it
Term
tumor-suppressor
Definition
2nd control; suppresses tumor growth
Term
DNA repair
Definition
3rd control; controls cell and tumor growth
Term
apoptosis
Definition
4th control; normal cell death
Term
1st growth phase
Definition
1st phase in the cell cycle; also called G1 phase; growth and normal metabolic roles
Term
synthesis phase
Definition
2nd phase in the cell cycle; also called S phase; DNA replication
Term
2nd growth phase
Definition
3rd phase in the cell cycle; also called G2 phase; growth and preparation for mitosis
Term
mitotic phase
Definition
4th and final phase in the cell cycle; also called M phase; consists of prophase, metaphase, anaphase, and telophase (in that order)
Term
tumor
Definition
abnormal growth of body tissue; can be malignant (cancerous) or benign (non-cancerous); needs nutrients, oxygen, and blood supply to grow
Term
localized tumor
Definition
initial stage; remains in area of origin
Term
invasive tumor
Definition
1st step in metastasis; tumor spreads to surrounding tissues and lymph nodes
Term
metastatic tumor
Definition
tumor spreads to distant site; most common route of metastasis is via blood or lymph channels
Term
C a u t i o n
Definition
stands for change in bowel or bladder habits; 1st of the 7 warning signs of cancer
Term
c A u t i o n
Definition
stands for a sore that does not heal; 2nd of the 7 warning signs of cancer
Term
c a U t i o n
Definition
stands for unusual bleeding or discharge; 3rd of the 7 warning signs of cancer 
Term
c a u T i o n
Definition
stands for thickening or lump in the breast or elsewhere; 4th of the 7 warning signs of cancer
Term
c a u t I o n
Definition
stands for indigestion or difficulty swallowing; 5th of the 7 warning signs of cancer
Term
c a u t i O n
Definition
stands for obvious change in a wart or mole; 6th of the 7 warning signs of cancer
Term

c a u t i o N

Definition
stands for nagging cough or hoarseness; 7th and last of the 7 warning signs of cancer
Term
TNM method
Definition

type of tumor staging

T: primary tumor

N: nodal involvement

M: distant metastasis

Term
cure
Definition
eradicate the cancer and promote long-term survival; 1st of the 4 goals of treatment
Term
control
Definition
to arrest tumor growth; 2nd of the 4 goals of treatment
Term
palliation
Definition
to alleviate symptoms when the disease is beyond control (followed by pain control and hospis); 3rd of the 4 goals of treatment
Term
prophylaxis
Definition
to provide treatment (preventative surgery or preventative medication) when no tumor is detectable but the patient is known to be at high risk for tumor development; 4th of the 4 goals of treatment
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