Term
| 3 Benefits of Inflammation |
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Definition
localizes area of injury
removes cellular debris and pathogens
sets stage for repair process |
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Term
| Role of Neutrophils in Inflammation |
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Definition
phagocytosis
release chemotatic factors that attract other neutrophils |
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Term
| Role of Monocytes in Inflammation |
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Definition
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Term
| 3 Major Stages in the Inflammatory Response |
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Definition
increased vascular permeability
emigration of leukocytes
phagocytosis |
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Term
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Definition
diluts harmful substances
brings in oxygen and nutrients
brings in clotting proteins |
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Term
| Cause of Vasoconstriction in Inflammation Response |
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Definition
direct injury to smooth muscle
chemical released by endothelium and platelets
reflexes initiated by local pain receptors |
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Term
Cause of Vasodilation in Inflammation Response
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Definition
| release of vasoactive chemical from local mast cells and other cells such as histamine, serotonin, bradykinin, prostaglandins |
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Term
| Purpose of Skin as Natural Barrier |
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Definition
prevents infectious agents from entering the body
secretions maintain a pH at 5.6 |
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Term
| Preformed Mediators in Anaphylatoxic |
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Definition
histamine
ECG & NCF
platelet activating factor
interleukins |
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Term
| Newly Synthesized in Anaphylatoxic |
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Definition
leukotrines
prostaglandins
thromboxanes |
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Term
| Effect of Vascular Permeability |
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Definition
alteration in osmotic pressure
-decreases in intravascular
-increases in interstitium
outflow of fluids and plasma proteins |
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Term
| Classical Pathway Outline |
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Definition
antibody involvement or lectin in bacterial cell wal
C1q binds to antibody in immune complexes and triggers proteolytic activity in C1r and C1s
C1 complex binds to and C4 to C4b and C2 to C2b
C4b and C2b combine to form C3 convertase
C3 convertase splits C3 into C3a and C3b
C3b combines with C4bC2b to form C4bC2bC3b |
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Term
| Alternate Pathway Outline |
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Definition
does not need antigen/antibody complex
microbials cause direct activation of C3
C3 complexes with Factor B to form C3bB
Factor D splits C3bB to form C3 convertase
properidin stabilizes the new C3 convertase
C3 is split by C3bBb to form C3a and C3c |
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