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Pathophysiology
GI
61
Medical
Not Applicable
03/28/2008

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Term
stress ulcer
Definition
ulcer that follows sever illness and trauma?
Term
Hemorrhage-most common
Perforation-not common
Pylric obstruction-from repeated cycles of damage/healing.
Definition
Major complications of Peptic ucler disease?
Term
meconium ileus
Definition
caused by lack of digestive enzymes during fetal development often from CF.
Term
intusseusception
Definition
obstruction caused by the telescoping of one part of the colon an another part
Term
intussusception
Definition
most frequent cause of acquired obstruction of the intestines in infants?
Term
volvulus
Definition
twisting of the intestines on its mesenteric pedicle
Term
Crohns
Definition
Crohn or Ulcerative Colitis?
Transmural
Term
Ulcerative colitis
Definition
Crohn or Ulcerative Colitis?
Isolated to mucosa, submucosa
Term
Crohns
Definition
Crohn or Ulcerative Colitis?
80% small intestine involved
Term
crohns
Definition
Crohn or Ulcerative Colitis?
skip lesion
Term
ulcerative colitis
Definition
Crohn or Ulcerative Colitis?
continuous lesions in rectum and sigmoid colon
Term
crohns
Definition
Crohn or Ulcerative Colitis?
non bloody diarrhea
Term
ulcerative colitis
Definition
Crohn or Ulcerative Colitis?
bloody diarrhea
Term
crohns
Definition
Crohn or Ulcerative Colitis?
Crohn or Ulcerative Colitis?
malignant potential is low
Term
crohns
Definition
Crohn or Ulcerative Colitis?
pain located on right side
Term
ulcerative colitis
Definition
Crohn or Ulcerative Colitis?
pain located on left side
Term
ulceraive colitis
Definition
Crohn or Ulcerative Colitis?
which is more common?
Term
uclerative colitis
Definition
Crohn or Ulcerative Colitis?
rectal involvement 95%
Term
crohns
Definition
Crohn or Ulcerative Colitis?
avoid surgery
Term
steatorrhea
Definition
term for fat in feces from malabsorbtion
Term
A protein found in wheat, rye, oats and barley
Definition
What is gluten?
Term
when gluten becomes toxic to the intestinal epithelial cells of certain individuals
Definition
what is gluten sensitive enteropathy?
Term
non tropical sprue
celiac disease
Definition
other names for gluten sensitive enteropathy?
Term
change/loss in villi
inflammation and edema
loss of brush border enzymes
malabsorbtion due to above
Definition
Patho of gluten enteropathy?
Term
diarrhea
FAILURE TO GROW
pale bulky stools
irritability
anorexia
ADULTS
steatorrhea
lassitude(fatigue)
Definition
clinical manifestations of gluten sensitive enteropathy?
Term
esophageal atresia
Definition
congenital loss of normal opening of esophagus
Term
Lepfin
Definition
New GI hormone that suppresses appetite
Term
Phagocytic cells that line the sinusoids of the liver.
Part of the immune system
Detox, lysis of old RBCs
Definition
Role of the Kupffer cell?
Term
Provides 25-30% of total blood to liver
Oxygenated
Definition
Hepatic artery?
Term
Provides 75% of total blood to liver.
Transports nutrients and toxins
Definition
Portal vein?
Term
lipid
Definition
unconjugated bilirubin is ____ soluble?
Term
water
Definition
conjugated bilirubin is ___ soluble?
Term
Uptake, Conjugation, excretion
Old RBC is destryed and unconjugated bilirubin is a byproduct.
Liver picks up the unconjugated bilirubin
liver conjugates it-makes it water soluble
Liver excretes this into the ileum and colon
Bacteria in the intestines convert the conjugated bilirubin to UROBILINOGEN
excreted in stool(small) and urine
Definition
explain bilirubin metabolism.
Term
after meals
Definition
Liver glycogenisis occurs when?
Term
between meals
overnight
times of stress
work to stabilize glucose levels
Definition
liver glycogenolysis and gluconeogenesis occur when?
Term
Vagal stimulation
Cholecystokinin
Definition
what stimulates the release of bile within the gallbladder?
Term
stimulates secretions
Definition
parasympathetic affect on pancreas?
Term
High bicarb concentration to neutralize acid contents of the duodenum
Definition
Role of the fluid/electrolyte secretions of the pancreas?
Term
secretin-stimulates ducts to release the alkaline fluid/electrolyte solution
into the duodenum
Cholecystokinin-stimulates the release of enzymes
Definition
Role of secretin and cholecystokinin in relation to the pancreas?
Term
prevents the digestion of pancrease itself.
Definition
purpose of trypsin inhibitor?
Term
distended torturous collateral vessels in lower esophagus or rectum due to portal hypertension
Definition
What are Varices?
Term
Rectum and esophagus
painless
Definition
common locations of varices?
Painful or painless?
Term
enlarge spleen due to backup of blood
will cause anemia and thrombocytopenia due to trapping.
Definition
effect of portal hypertension on spleen?
Term
accumulation of fluid in the peritoneal cavity due to increased hydrostatic pressure r/t portal hypertension
Definition
what is ascites?
Term
wt gain- from edema
resp distress- pressure on diphragm
peritonitis-fever, pain, dec. bowell sounds, cloudy fluid.
Definition
clinical manifestations of ascites?
Term
CNS disturbance r/t:
hypoxia
accumulation of ammonia
Definition
what is hepatic encephalopathy?
Term
mental confusion
muscle tremors(asterixis)
impaired cerebral function
STAGES 1-4
Definition
clinical manifestations of hepatic encephalopathy?
Term
another word for jaundice
Definition
what is icterus?
Term
hepatitis
Definition
inflammation of the liver due to a virus is?
Term
biliary canaliculi
Definition
hepatitis can obstruct the ___ and cause jaundice?
Term
Preicteric
2 weeks after exposure
adversion to food odor, etoh and smoking
RUQ pain is common
wt loss
Definition
Prodromal phase of hepatitis
Term
Begins with jaundice
enlarged liver
fatigue
ruq pain is worse
inc serum enzymes
inc PT
itching
lasts 4-6 wks
Definition
Icteric phase of hepatitis?
Term
sx diminish
labs normal
Definition
recovery phase of hepatitis?
Term
breastmilk has a compound that increases the amount of unconjugated bilirubin in the gut
Definition
why do breastfed babies have higher incidence of jaundice?
Term
serious complication of permature birth, neonatal jaundice, and hemolytic disease of the newborn.
immature blood-brain barrier allows unconjugated billirubin to enter the brain where it alters nerve function
can cause death, cerebral palsy, MR, and mental d/o
Definition
what is kernicterus?
Term
phototherapy
converts unconjugated bilirubin into water soluble forms that can be excreted by the kidneys
Definition
tx for kernicterus?
Term
fatty infiltration of the liver with sever hepatic dysfunction
usually occurs after viral illness (flu or chickenpox)
Definition
what is reyes syndrome?
Term
reyes syndrome
Definition
Pediatric consideration to watch for after a pt has the flu or chickepox?
Term
aspirin-causes reyes syndrome
Definition
what drug should be avoided with peds?
Term
autosomal recessive d/o
causes excessive and ucontrolled iron absorption in the GI system and deposits it into the liver, causing cirrhosis
Definition
what is hemochromatosis?
Term
elderly
Definition
what age group does hemochromatosis commonly occur?
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