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Pathophysiology
Chapter 25, 26, 27
95
Biology
Undergraduate 1
04/01/2012

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Term
Upper airways
Definition

Has the nasopharynx, oropharynx, and protective functions

 

Term
Larynx
Definition
this connects upper and lower airways and has a protective function
Term
upper airways
Definition

1) warms, humidifies, and filters inspire air

2) protects the lower airways from foreign matter

Term
sttuctures of the pulmonary system
Definition

airways

pulmonary circulation

chest wall

lungs (three lobes on right and two lobes on the left)

Term
lower airways
Definition
this has the trachea, bronchi, and terminal bronchioles
Term
hypoxemia
Definition
insuffienct o2 in the blood and the first step to hypoxia
Term
Hypoxia
Definition
lack of 02 available to body tissue
Term

mucus and cilia

 

Definition
respiratory bronchioles has
Term
alveolar ducts
Definition
these branches out from the bronchioles
Term
epithelial cells
Definition
Alveoli type I is
Term
alveolar cells
Definition
Alveoli type II is
Term
structure; thin
Definition
the alveolar type I epithelial cells gives the alveolus it's__________ and has a very ______ gas-permeable components of the blood air barrier
Term
secretory, surfactant, collapse
Definition
Alveolar Type II alveolar cells has _______cells, ______production, and prevents the ________of the alveoli
Term
venous pressure system
Definition
pulmonary circulation is a
Term
pressure
Definition
in pulmonary and bronchial circulation it increase in cardiac out but doesn't increase
Term
1/3
Definition
how many of the pulomnary vessels are filled with blood?
Term
enters the lung
Definition
pulomary artery divides and
Term
capillary walls
Definition
the alveolo-capillary membrane is formed by the shared alveolar and
Term
alveolo-capillary membrane
Definition

the membrane that gas exchange occurs in

 

Term
Chest wall
Definition

Has:

-skin

-ribs

-intercoastal muscles

-Thoracic cavity

Term
pleural cavity
Definition
the thin space between the two pleural layers that contains fluid to reduce friction
Term
parietal pleura
Definition
this pleura is attached to the chest wall and senses pain
Term
visceral pleura
Definition

pleura that covers the lungs

 

Term
ventilate; oxygenate
Definition

the function of the pumonary system is t:

bring air in to the lungs _________

-diffuse gases into and out of the blood ____________

Term
minute volume
Definition

how much air is moved in one breath

ventilatory rate X volume of are per breath

Term
Alverolar ventilation
Definition
how much air is available to the alveoli
Term
neurochemical
Definition

Ventilation is a ________control

 

Term
involuntary and voluntary
Definition
respiratory center is both
Term
brain stem
Definition
the respiratory center is in the
Term
medulla oblongata
Definition
neurochemical control for ventilation is in the
Term
dorsal respiratory group
Definition
automatic rhythm of breathing
Term
ventral respiratory group
Definition
active when voluntary control is needed
Term
pneumotaxic and apneustic center
Definition
modifies the dorsal and ventral respiratory groups and prevents overinflation of lungs
Term
irritant, stretch, and j-receptors
Definition
receptors to the dorsal respiratory group are
Term
Chemoreceptors
Definition
this reacts to ph, PaCo2, and PaO2
Term
pH
Definition
acidosis causes increased breathing
Term
PaCO2
Definition
increase ventilation; increases respiratory rate
Term
PaO2
Definition
not a primary drive but when there is a chronic hypoventilation , ther will be increased CO2 so then this becomes primary and when this goes down, the respiratory rate also goes down
Term
acidosis
Definition
< 7.35
Term
Alkalosis
Definition
> 7.45
Term
diaphragm and external intercostals
Definition
major muscles of inspiration is
Term
diaphragm
Definition
pulls its self down and increases the thoracic volume
Term
external intercostals
Definition
contacts to increase AP diamater
Term
sternocleidomastoid and scalene muscles
Definition
Accesory muscles of inspiration (increase AP diameter)
Term
abdominal and internal intercostal muscles
Definition
accessory muscles of expiration (not needed usually)
Term
negative
Definition
when the chest wall move out and up it increases the amount of _____pressure to allow air to move in
Term
decreases
Definition
chest muscle realxes it ________ space and air goes out
Term
decrease
Definition
when the surface tension (surfactant) is _______this allow the alveoli and lung to expand
Term
elastic recoil
Definition
returns to the resting state like a balloon
Term
compliance
Definition
how easily it stretches
Term
low
Definition
airway resistance is normally______, 2/3 of total resistance is in the nose
Term
Sympathetic
Definition

fight or flight;

-bronchial smooth muscle relaxes which increases the diameter of the airway

-respiratory rate increases

-increased glucose for muscle function

Term
Parasympathetic
Definition

-bronchial muscles constrict narrowing airway

-mucus production increase

Term
Gas transport
Definition

1. ventilation of the lungs

2. Diffusion of oxygen from the alveoli into the capillary blood

3. perfusion of systemic capillaries with oxygenated blood

4. Diffusion of oxygen from systemic capillaries into the cells

Term
reverse
Definition
Diffusion of Co2 occurs in ________
Term
gravity and the alveolar pressure
Definition
the distribution on gravity and alveolar pressure depends on
Term
normally .8 but ideal is 1
Definition
The ventilation-perfusion ratio is
Term
Apex
Definition
ventilation is greater than perfusion
Term
Base
Definition
perfusion is greater than ventilation
Term
diffusion
Definition
oxygen transport is by
Term
arterial oxygenation
Definition
this oxygenation depends on the amount of oxygen and hemoglobin
Term
Right shift
Definition

decreased affinity for O2 (releaser easier)

ex:acidosis

Term
left shift
Definition
increase of HB afficity for O2 (held on)
Term
right shift
Definition
measurement of gas pressure: decrease HB affinity for O2 (released easier)
Term
left shift
Definition
measurement for gas pressure: Increase HB affinity for O2 (held on to)
Term
Carbon dioxide transport
Definition

-dissolved in plasma

-bicarbonate (-HCo3)

-attacheed to hemoglobin

Term
60%
Definition
_______ of Co2 in venous
Term
90%
Definition
____co2 in arterial blood is in form of -Hco3 ( out from kidneys)
Term
Haldane effect
Definition
o2 release from hemoglobin in tissues and combination of 02 with hemoglobin in lung promotes CO2 movement as desired
Term
hypoxic pulmonary vasoconstriction
Definition

-caused by low alveolar PO2

-the body will not send blood where there is no air and n o air where thereis no blood

-hypoxia affects all segments of the lungs because of vasoconstriction which can lead to pulmonary hypertension (increase pressure)

Term
filtration, humifies, and heat supply
Definition
function of lower airway
Term
cilia
Definition
lining of the bronchial is
Term
Alveoli
Definition

-300 million

-site of diffusion of oxygen and carbon dioxide

-type I pneumocytes (epthelial) blood air barrier

-Type II pneumocytes (alveolar cells)- produce surfactant

Term
respiratory bronchioles and alveoli
Definition
gas exchange units are the
Term
Respiration
Definition
process by which O2 is transferred from the air to tissue and CO2 is excreted in the expired air
Term
Tidal volume (Vt)
Definition

volume of air moved in and out of lungs with each normal breath

7ml/ kg

about 500 ML

Term
Inspiratory Reserve Volume (IRV)
Definition

volume of air that can be maximally inspired above the normal inspiration

3000

Term
Expiratory REserve Volume (ERV)
Definition

volume of air that can be maximally exhaled beyond the normal expiration

1000 mL

Term
Residual Volume (RV)
Definition

volume of air remaining in the lungs at the end of maximal expiration

1000 ML

Term

Inspiratory Capacity

 (IC)

Definition

Vt  + IRV; volume of air that can be maximally inspired from a normal expiration

3,500 mL

Term
Functionally residual capacity (FRC)
Definition

RV +ERV; volume of air remaining in the lungs at the end of normal expiration

2,000 mL

Term
Vital Capacity (VC)
Definition

 Vt + IRV + ERV; volume of air that can be maximally expired after a maximal inspiration

4,500

Term
Total lung capacity
Definition

VT+irv+erv+rc; volume of air that the lungs can hold with maximal inspiration

5,500-6,000 mL

Term
respiratory rate or frequency (f)
Definition

breaths per minute

12-20

Term
minute ventilation
Definition

volume of air expired per minute

5-10 L

Term
Dead space ventilation (VD) anatomic dead soace + alveolar dead space
Definition

volume or percent of sinpired air that is not involved in gas exchange

normal is .4

if it's greater than .6 intubation is needed

Term
alveolar ventilation
Definition

VT-Vd; volume of air that is involved in alveolar gas exchange

 

350 mL

Term
Forces vital capacity
Definition

volume of air in a forcced maximal expiration

 

4500 mL

Term
Forced expiratory volume
Definition

volume of air exhaled in a given time period

 > 75% i snormal

Term
deadspace ventilation
Definition
volume of inspired air that doesn't participate in gas exchange
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