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Pathophysiology Test #3
Review
88
Nursing
Graduate
07/25/2011

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Cards

Term
Thyroid gland
Definition
-negative feedback loop
-regulated by pituitary and hypothalamus
-regulates and controls metabolism
Term
What hormones are secreted by thyroid gland?
Definition
TSH, TRH, T3, and T4
Term
Primary dysfunction
Definition
problem is actual thyroid
Term
Secondary dysfunction
Definition
problem is pituitary/ hypothalamus
Term
Hypothyroidism
Definition
-slow-sumo
-decreased metabolism appetite speech HR , increased weight cholesterol , cold, fat face, puffy eyes, depression, fatigue, coarse brittle hair, edema
Term
Hasimotos disease
Definition
-primary cause of hypothyroidism
-gradual destruction of thyroid tissue by lymphocytes and autoantibodies
-small thyroid
Term
Iodine deficiency
Definition
-most commone cause of hypothyroidism world wide
-primary cause
-iodine is required to make T3 and T4
-large thyroid
Term
Secondary causes of hypothyroidism
Definition
trauma
cancer
brain infection
neurosurigical procedures
Term
myxedema
Definition
-severe hypothyroidism
-coma when everything bottomsout
-S/S non pitting boggy edema around eyes, hands, feet;thick tongue
Term
Labs for primary problem hypothyroidism
Definition
T4 decreased
TDH increased
Term
Labs for secondary problem hypothyroidism
Definition
T4 decreased
TSH increased
Term
Primary cause of hyperthyroidism
Definition
Graves Disease
Ingestion of excess thyroid
Term
Graves Disease
Definition
-Autoimmune stimulation of thyroid
-decreased TSH and increased T3/T4
Term
Secondary cause of hypothyroid
Definition
-rare
-TSH secreting pituitary adenoma
-will increase T4/T3 and TSH
Term
S/S of hyperthyroidism
Definition
decreased weight
increased metabolism
increased appetite
Increased HR, BP
Thin falling out hair
big thyroid
hyperthermia
warm skin
sweaty palms
Term
lab results of hyperthyroidism
Definition
primary: decreased TSH
secondary: increased TSH
both T3/T4 increased
Term
Thyroid toxic crisis
Definition
-thyroid storm
-S/S increased temp and HR, delirium, everything goes up
-cardiac dysrhytmias kill them
Term
insulin
Definition
-takes glucose into cell
-produced by beta cells
Term
glycogenesis
Definition
-process of glycogen synthesis
-glucose molecules are added to chains of glycogen for storage
Term
glyconeogenesis
Definition
metabolic pathway that results in the generation of glucose from non-carbohydrate substances
Term
glycolosis
Definition
conversion of glucose to pyruvate ending with ATP formation
Term
glycated hemoglobin
Definition
-Hg A1C
-form of blood test used to identify the average plasma glucose concentration of a period of 3 months
Term
Fasting Glucose lab values
Definition
>126 times to is diagnosis of diabetes
Term
what substances inhibit insulin
Definition
glucagon
epi
glucosteroids
growth hormone steroids,
Term
Hypoglycemia
Definition
-BS < 70
-caused by too much insulin
-S/S shaky, tremors, irritable, sweating, cold/calmy, confused, disoriented, fainting
Term
Hyperglycemia
Definition
-to much sugar not enough insulin
-S/S hot, dry skin, 3 P's, dehydration, ketones
Term
Type 1 Diabetes
Definition
-No insulin production
-onset is young
-skinny, hyperglycemic, ketones, 3 P's
-90% of pancreas is gone before symptoms appear
Term
Causes of Type 1 Diabetes
Definition
-genetic autoimmune (gradual destrcution of B cells)
-viruses
-sudden symptoms (the 1st sign could be DKA)
Term
DKA
Definition
-Diabetic Keto Acidosis
-Sudden onset
-life threatening but reversiable
-precipitated by another stressor
-S/S 3 P's , Kushmal respirations, altered LOC
-treat with insulin
Term
Type 2 Diabetes
Definition
-High glucose intake over time
-gradual onset
-50% Beta cell function lost by time of symptoms
-insulin resistant
Term
S/S of Type 2 Diabetes
Definition
obesisty
HTN
3 P's
fatigue
recurrent infections
neuropathy
vascular problems
Term
NKHHC
Definition
-Non Ketoic hyperglycemic hyperosmolar coma
-prolonged increase in blood sugar
-caused by a stressor
-no ketones present
-S/S gradual onset, profound diuresis, dehydration, normal pH, increased BS
-Treat with insulin and fluids
Term
C peptide test
Definition
measures the beta cells ability to produce insulin
Term
Kidney Functions
Definition
1. Remove waste
2. regulate fluid volume and BP
3. Acid/base balance
4. filter plasma
5. reabsorb nutrients
6. make erythopoeitin
Term
Aldosterone
Definition
retain Na and H2O
Term
ADH
Definition
retain H2O
Term
RAS
Definition
renal blood flow regulator
Term
GFR
Definition
-directly related to renal blood flow
-the more blood getting to the kidneys the more they can filter
-used for stating renal failure
Term
nephron
Definition
functional unit of the kidney
Term
Glomerulus
Definition
-ball/tuft of capillaries that attaches to proximal tubule
-protein control
Term
proximal tubule
Definition
reabsorbs Na
Term
Loop of Henele
Definition
concentrates or dilutes urine
Term
Distal tube
Definition
-reabsorb Na and H2O
-excretes K, urea, H and ammonia
Term
What do you look at to asses for renal fxn in a UA
Definition
glucose, ketones, protein, blood, WBCm nitrates
Term
prerenal failure
Definition
-problem is there is no perfusion to the kidney so no blood to the kidneys
-ex. hypo or hyper tension, blood loss, renal artery stenosis, nephrosclerosis, heart failure, sepsis, dehydration
-
Term
intrarenal kidney failure
Definition
-problem is in kidney, there is direct damage to kidney
-ex. glomerural nephritis, acute tubular necrosis
Term
postrenal kidney failure
Definition
-casued by an obstruction
-urine backs up into the kidneys causing damage
-ex. tumor, kidney stone, enlarged prostrate
Term
glomerular nephritis
Definition
-caused by an infection (usually strpe)
-S/S hematuria, protinuria, decreased GFR, oliguria, edema
-Treat the infection, and will usually resolve on own
Term
Nephrotic Syndrome
Definition
-a 3.5g of protein lost per day
-more common in kids
-S/S edema (anasarca)
-Treat by adding protein to diet, diuretics, and steroids
Term
chronic renal failure
Definition
-progressive deterioration in renal function resulting in fatal uremia
-irreversible
Term
Stage 1 renal failure
Definition
decrease renal reserve
Cr and BUN are normal
Term
Stage 2 Renal Failure
Definition
renal insufficiency
have lost 75% of renal function
Term
Stage 3 Renal Failure
Definition
ESRD
uremic syndrome
Term
GI alterations with ESRD
Definition
N/V
anorexia
fetor (uremic breath)
hyperkalemia
Term
Neuro alterations with ESRD
Definition
uremic encephalopathy
seizures
coma
decreased level of consciouness
Term
cardiac alterations with ESRD
Definition
increased workload
increased BP
fluid volume excess
anemia
Term
respiratory complications with ESRD
Definition
uremic fetor
metabolic acidosis
Term
skin alterations with ESRD
Definition
grey pallor
urea out of pores
uremic frost
puritis
Term
UTI
Definition
-caused by ecoli in stool
-can occur anywhere along urinary tract (urethra, prostrate, bladder, ureter, kidneys)
Term
uncomplicated UTI
Definition
-lower UTI
-urethra'
-normal urinary system
-no complications
Term
complicated UTI
Definition
-defect in urinary system
-occurs from other health problems
Term
systitis
Definition
bladder infection
Term
systitis
Definition
bladder infection
Term
pyelonephrtis
Definition
kidney infection
upper urinary tract
Term
Risk factors for UTI's
Definition
1. premature babies or babies with deformity in UT
2. Woman- shorter urethra
3. People with catheters
4. People with decreased urine output
Term
causes of pyelonephrtisis
Definition
ecoli
kidney stones
neurogenic bladder
female sexual trauma
catheters
Term
S/S of pyelonephrtis
Definition
fever
chills
flank/CVA tenderness
frequency
dysuria
rigor
hematuria
bacteria, nitrates, WBC, pus in urine
Term
Kidney stones
Definition
-mass of Ca cells
-dehydration is a risk factor
-pain in lower back
-treated by pain meds, fluids, straining urine, surgical removal
Term
Gonorrhea
Definition
-characterized by white drainage between urination
-usually asymptomatic
-burning with urination
-can cause PID in woman
Term
PID
Definition
-abdominal pain/fever
-causes infertility
Term
Chlamydia
Definition
-most common STD
-mostly asymptomatic
-discharge/burning
-for woman it gets into the fallopian tubes
-symptoms within 1-3 weeks
Term
Chlamydia
Definition
-most common STD
-mostly asymptomatic
-discharge/burning
-for woman it gets into the fallopian tubes
-symptoms within 1-3 weeks
Term
trichomonas vaginalis
Definition
-no symptoms in men
-woman have frothy green/yellow discharge that smells like dead fish
-parasite
Term
primary syphilis
Definition
-canker sore
-1cm or less
-painless
-don't usually think anything about it
Term
secondary syphilis
Definition
sores on hands and feet
Term
tertiary syphilis
Definition
-occurs when primary or secondary is not treated and it gets to the brain
Term
Herpes Type 1
Definition
mouth, cold sores
Term
Herpes Type 2
Definition
Genitals
4.5 million americains
condoms don't help
1 in 4 people
Term
S/S of Herpes
Definition
-painful fluid filled vesicles
-<1 cm
-multiple
-red based
Term
HPV
Definition
-many strains
-some strains cause cervical cancer and some cause genital warts
-guys don't know they have it
-vacine available for some strands
Term
risk factors for cancer
Definition
age
smoking/tobacco use
alcohol and drugs
unhealthy diet
no exercise
excessive sunlight
sexual behavior
radiation
viruses/bacteria
pesticides
Term
carcinomas
Definition
-changes in epithelial tissue
-skin cancer (melanoma )
Term
adencarcinomas
Definition
-glandular tissue cancer
-breasts, prostrate, colon, pancreas, lung
Term
sarcoma
Definition
muscles and bones
Term
iniation
Definition
-carcinogen damages DNA
-gene will either repair itself or mutate
Term
promotion
Definition
uncontrolled cell growth and replication
Term
progression
Definition
angiogenesis
Term
metastasize
Definition
when the tumor spreads to other areas
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