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Pathophysiology - Male Reproductive System
Fall Semester - 2010 (Test 5 - PPT 2)
78
Medical
Graduate
11/16/2010

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Term
What is thearche? When does it begin?
Definition
breast development; begins at 8 - 9 y/o
Term
What is adrenarche? What occurs during this process?
Definition
An increase in the production of sex hormones; Genitalia grow into their adult proportions and secondary sex characteristics develop
Term
What male sex organ produces sex hormones and gametes?
Definition
Testes
Term
What male sex organ conducts sperm from the efferent tubules to the vas deferens and supplies nutrients and testosterone to enhance the maturity of sperm?
Definition
Epididymus
Term
What part of the scrotum contracts and relaxes to keep sperm at optimum temperature?
Definition
Tunica dartos
Term
What type of fluid is secreted by the prostate gland?
Definition
secretes prostatic fluid with alkaline pH
Term
What type of fluid is secreted by the cowper's gland?
Definition
Secretes mucus
Term
What is the site of spermatogenesis? How long does spermatogenesis take?
Definition
semineferous tubules
70 - 80 days
Term
Which cells provide further nutrients and hormonal signals to help develop the sperm?
Definition
sertoli cells
Term
Where are androgens mainly produced?
Definition
Leydig cells of the testes (& adrenal glands)
Term
Which condition is a nonmalignant overgrowth of the prostate gland?
Definition
Benign Prostatic Hyperplasia (BPH)
Term
If a male pt presents with urinary sx including urgency, hesitancy, incomplete emptying (fullness), terminal dribbling or complete urinary retention what condition might you suspect?
Definition
BPH
Term
How is BPH diagnosed?
Definition
Digital Rectal Exam (DRE)
Term
What is the treatment for BPH?
Definition
5 alpha-reductase inhibitors
alpha-blockers
Term
What lab can you use to monitor BPH? At what level for this lab result is a transrectal biopsy recommended?
Definition
PSA (Prostate Specific Antigen) - moderately elevated in 30 - 50% of patients with BPH
If PSA is > 4ng/mL then transrectal biopsy is recommended
Term
With cryptorchidism what are those pts at a greater risk for later in life?
Definition
At a greater risk for testicular malignancy and infertility
Term
What is orchipexy?
Definition
Surgical repositioning of the testis
Term
What condition is defined as the inability to attain or sustain an erection for sexual intercourse 25% of the time?
Definition
Erectile Dysfunction
Term
Which type of impotence is described as an inability to maintain an erection at any time in their life (never had an erection)? What is this condition often related to?
Definition
Primary Erection
Often related to a longstanding psychiatric problem or vascular trauma
Term
Which type of impotence is described as the individual no longer being able to maintain an erection but they have had normal erections in the past?
Definition
Secondary Impotence
Term
What are some common causes of ED? (esp those that can be prevented/controlled)
Definition
Atherosclerosis
HTN
DM
PVD
Obesity
Heart Disease
Stroke
Metabolic Syndrome
Meds
Tobacco, Alcohol, and Drug Abuse
Term
Which meds may cause ED?
Definition
Antihistamines
SSRIs (Prozac and Paxil)
anti-HTN meds (propranolol, MAOs, thiazides)
Phenothiazines
Term
During evaluation for ED, which hormone levels are tested?
Definition
Testosterone
FSH
LH
TSH
PRL
Term
Which nerve is affected in diabetics who have ED?
Definition
Pudendal Nerve
Term
What are some operations that can cause ED?
Definition
Aortoiliac Vascular Surgery
TURP
Term
What meds can be used to treat ED?
Definition
Viagra
Cialis
Levitra
Term
Which condition is causes the scrotum enlarge with abdominal fluid when the patient is upright and empties when he lies down?
Definition
Congenital hydrocele
Term
Which condition is described as non-communicating fluid enlargement of the scrotum whose size may fluctuate when an imbalance occurs between production and absorption of fluid?
Definition
Adult hydrocele
Term
How can you detect a hydrocele on PE?
Definition
Transillumination of scrotal enlargement
Term
What is the treatment for hydrocele? What are these patients at an increased risk for?
Definition
hydrocelectomy (if persistant)
aspiration
Increased risk for secondary infection and vascular injury
Term
What condition is described as a collection of large veins superior to the testicle? In which position is this condition visible?
Definition
Varicocele
Present in upright position, not present in the supine position.
Term
What condition is a painless cystic scrotal mass that usually occurs at the upper pole of the testis adjacent to the epididymis? How is this condition treated?
Definition
Spermatocele
Usually left untreated, if large or bothersome surgical excision is done
Term
Does a spermatocele transilluminate?
Definition
Yes
Term
Does incontinence affect men or women more?
Definition
affects Women 2x more than men
Term
What bladder abnormality can cause incontinence?
Definition
Detrusor over-activity, poor compliance
Term
What sphincter abnormality can cause incontinence?
Definition
Urethral hypermobility, intrinsic sphincter deficiency
Term
Which type of incontinence is described as a strong and immediate urge to void? What is this type of incontinence caused by?
Definition
Urge Incontinence
Caused by involuntary detrusor contraction
Term
Which type of incontinence is described as increased abdominal pressure combined with pelvic muscle laxity that causes incontinence with laughing, sneezing, and physical exertion? What conditions cause an increased risk of developing stress incontinence?
Definition
Stress Incontinence
Vaginal deliveries, high maternal weight gain, prostatectomy
Term
Which type of incontinence is described as caused by urinary retention and an overextended bladder?
Definition
Overflow Incontinence
Term
What is urolithiasis indicative of? Where are these calculi located? What are theses calculi composed of?
Definition
Urinary retention
Located in the Bladder
Composed of Uric acid
Term
If a pt presents with bladder irritation (intense pain), obstruction, infection, hematuria, pyuria or dysuria, what condition do you suspect?
Definition
Urolithiasis
Term
What are nephrolithiasis found?
How can you tell the difference between calcium oxalate and cystine nephrolithiasis?
Definition
Anywhere in the urinary tract
Calcium Oxalate - radiopaque, cystine - radioluscent
Term
What are some precipitating factors of Nephrolithiasis?
Definition
supersaturation, abnormal urine pH, low urine volume
Term
At what size do nephrolithiasis do they pass spontaneously? At what size do they require a urological referral?
Definition
< 5mm - Pass spontaneously
> 5mm - Urological referral
Term
What is the hallmark of nephrolithiasis?
Definition
Ureteral colic
Term
What is the hallmark of ureter colic?
Definition
Pain as the calculi moves down the ureter
Term
What was the gold standard for diagnosing Nephrolithiasis? What is used now for diagnosis?
Definition
IVP - former gold standard
Renal Ultrasound and CT Scan
Term
What condition is described as the inability to retract the foreskin over the glans penis?
Definition
Phimosis
Term
Is testicular torsion an emergency condition?
Definition
YES!!!
Term
Which condition is described as entrapment of retracted foreskin behind the glans penis?
Definition
Paraphismosis
Term
If a male patient presents with N/V, acute scrotal pain and swelling and on PE the cremaster reflex is absent on affected side what condition do you suspect? How can you confirm dx?
Definition
Testicular Torsion
color Doppler
Term
In which direction does the testicle usually turn with testicular torsion?
Definition
testes usually turn inward
Term
What condition is characterized by fibrosis of the cavernous sheath causing deviation of the erection towards the affected side as well as pain and incomplete erection?
Definition
Peyronie's Disease
Term
What are the primary bacterial causes of Cystitis?
Definition
E. Coli & Gram - Enterococci
Term
What are some causes of recurrent URIs?
Definition
anatomic abnormalities - duplicated/ectopic ureters
pathologic abnormalities - calculi, prostatis, foreign bodies
Term
What are the most common bacterial causes of Epididymitis in men < 35y/o?
Definition
STDs including N. Gonorrhoeae and C. Trachomatis
Term
What are the most common bacterial causes of Epididymitis in men >35y/o?
Definition
gram - coliform bacteria
Term
What condition would you suspect if the patient presents with unilateral scrotal pain and swelling, dysuria and fever?
Definition
Epididymitis
Term
What is the cause of orchitis?
Definition
ascending bacterial infection from the urinary tract
Term
With which common childhood bacterial infection is orchitis seen?
Definition
Mumps
Term
If the patient presents with fever, tachycardia, unilateral testicular edema and tenderness, what condition do you suspect?
Definition
Orchitis
Term
What bacterial organisms are common with prostatitis?
Definition
Pseudomonas aeruginosa
Serratia
Klebsiella
Proteus Sp
Enterococci
Term
What is the most common type of prostatitis?
Definition
Type III - chronic abacterial/chronic pelvic pain syndrome
Term
What is the most common cause of Pyelonephritis? What condition is a common cause of pyelonephritis?
Definition
ascending infection from the lower urinary tract
pregnancy
Term
What are some common STI pathogens that cause urethritis? What are the symptoms?
Definition
Gonorrhoeae and Chlamydia
Dysuria and d/c
Term
Which bladder cancer is the most common?
Definition
Transitional Cell
Term
What is the #1 risk factor for bladder cancer?
Definition
Cigarette smoking
Term
What is the key sign and symptom of bladder cancer? What else does this symptom have a cause for concern?
Definition
Hematuria (gross or microscopic)
Renal cancer should be a ddx for hematuria
Term
What can significant elevation of serum hCG produce? When is this elevated?
Definition
produces gynecomastia; elevated with testicular cancer
Term
When are many asymptomatic testicular cancer masses found?
Definition
detected during routine physical exam or during evaluation for infertility b/c testicular cancer can cause oligospermia
Term
What type of cancer are the majority of prostate cancers?
Definition
adenocarcinomas
Term
What are the symptoms of advanced stage of prostate cancer?
Definition
bladder outlet obstruction
hematuria
bone pain
Term
Which chromosome deficit is renal cell carcinoma linked to?
Definition
chromosome 3
Term
What is the classic triad of symptoms of renal cell carcinoma?
Definition
Hematuria,
flank pain,
palpable flank or abdominal mass
Term
With the Wilm's tumor, on what chromosome is the defect?
Definition
Defect on chromosome 11 and 12
Term
What are the symptoms of Wilm's tumor? In which pts is this condition seen?
Definition
HTN
palpable flank/abdominal mass
flank/abdominal pain
hematuria
Most common abdominal mass seen in 3 - 5 y/o
Term
How does renal cell carcinoma respond to radiation and chemotherapy?
Definition
It is resistant to both and therefore has a poor prognosis.
Term
If the Wilm's tumor affects the IVC what can occur?
Definition
IVC becomes blocked by tumor thrombus causing decreased venous return and lower extremity edema
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