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Pathology
Unit 1 Exam Material
250
Pathology
Graduate
02/08/2011

Additional Pathology Flashcards

 


 

Cards

Term
African American
Definition
What Race is most impacted by Hypertension
Term
Caucasian
Definition
What Race is most impacted by Cystic Fibrosis
Term
African American
Definition
What Race is most impacted by Sickle Cell Anemia
Term
Sickle Cell Anemia
Definition
Dehydration and Over Exertion will increase the chance of an attack in this disease along with severe joint pain.
Term
Primary Prevention
Definition
In regards to Prevention at this stage we try and remove or reduce dz risk factors
Term
Secondary Prevention
Definition
In regards to prevention at this state early detection and prevention of dz complications is key.
Term
Tertiary Prevention
Definition
Limiting the impact of the dz on function limitation; rehabilitation; prevent disabilities.
Term
Use of Tobacco
Definition
The use of ? can cause decreased circulation, decreased wound healing, increased back pain, osteoporosis in addition to CVD, COPD and cancer.
Term
Low Socioeconomic Status
Definition
Name the most adverse influence on health
Term
Heart Dz, Cancer, Stroke
Definition
Leading Cause of Death (3)
Term
Diet, Physical inactivity, smoking & alcohol abuse
Definition
Actual Cause of Death due to modifiable Behavioral and Lifestyle factors:
Term
Anorexia Nervosa
Definition
While purging behavior is common to both of these disorders, in this one the patient refuses to eat and restricts food.
Term
Anorexia Nervosa Signs & Symptoms
Definition
These are S&S of ? Disease: Extremely thin, Amenorrhea, emotional disturbances, fluid/electrolyte imbalance, malnutrition, multi-system involvement
Term
Cardiac Abnormalities S&S in Anorexia Nervosa
Definition
Cardiac Abnormalities in ? disease: Abnormal HR, Hypotension, Ventricular arrhythmias, Mitral valve prolapse, Cardiomyopathy and Heart Failure
Term
Cardiomyopathy
Definition
? is a Decrease in heart muscle which causes poor circulation.
Term
Mitral Valve Prolapse
Definition
When valve bulges back in the wrong direction - not enough blood.
Term
Musculoskeletal S&S in Anorexia Nervosa
Definition
Loss of muscle mass, muscle weakness, poor posture, gait disturbance, low bone density are all musculoskeletal S&S in ? disease.
Term
Neurologic Abnormalities S&S in Anorexia Nervosa
Definition
Neurologic Abnormalities in ? disease: Muscular spasms, peripheral paresthesia, seizures, cerebral atrophy
Term
Anorexia Nervosa
Definition
Tx: difficult and lengthy. Poor prognosis. Behavior therapy & counseling also needed. Goal is to normalize eating pattern, gain weight and improve function. (Name the disease)
Term
Anorexia Nervosa Implication for the PT. Exercise program considerations.
Definition
Bone Density & Cardiac Status. Monitor during therapy: lab values, vital signs and musculoskeletal stress signs. Obtain medical clearance first and consult and follow up with the physician.
Term
Bulimia Nervosa Physical Findings
Definition
tooth enamel erosion, irritation of upper GI, fluid/electrolyte imbalance, rectal bleeding with laxative abuse, psychiatric symptoms are all physical findings in ? disease.
Term
BMI: Less than 18.5
Definition
Anorexia Nervosa and Bulimia Nervosa BMI
Term
Bulimia Nervosa PT Implications
Definition
Monitor vitals, consult a physician, watch for signs of fluid/electrolyte imbalance during treatment, may show muscle weakness which could be dehydration. Prognosis Good: Full recovery. (These are all PT implications in ? disease)
Term
18.5 - 24.9
Definition
BMI: Normal (name the range)
Term
25 - 29.9
Definition
BMI: Overweight (name the range)
Term
Greater than 30
Definition
BMI: Obesity (name the range)
Term
STRESS: Clinical Manifestations
Definition
muscle tension, pain, restlessness, fatigue, hyperventilation are clinical manifestations of ?.
Term
Anxiety - Definition
Definition
General emotional state of fear & apprehension with increases of physiological arousal to stress.
Term
Anxiety: S&S
Definition
Anxious, afraid, fear, fright, restlessness, nervous, sweating, muscle tension increase, shaking, trembling, tachycardia, dyspnea are S&S in this disorder.
Term
General anxiety disorder, PTSD (posttraumatic stress disorder), panic disorder, OCD (obsessive-compulsive disorder), phobias.
Definition
Anxiety Disorders most commonly encountered in PT practice
Term
General Anxiety Disorder: Physical symptoms
Definition
Fatigue, headaches, muscle tension and aches, difficulty swallowing, trembling, sweating or hot flashes are all physical symptoms in this disorder.
Term
General Anxiety Disorder
Definition
Chronic anxiety, exaggerated worry or tension even when there is little or nothing to provoke it. Marked physical or emotional responses.
Term
PTSD
Definition
an anxiety disorder that develops after exposure to a terrifying event, usually one in which physical harm is threatened or occurred.
Term
PTSD
Definition
These Pts may experience "emotional numbness", sleeplessness or be easily startled. Have persistent frightening memories or thoughts that may interfere with daily life.
Term
Panic Disorder
Definition
Periods of sudden, unprovoked intense anxiety with associated physical symptoms. Recurrent panic attacks that occur unpredictably.
Term
Panic attack: (listed under panic disorder)
Definition
Sudden onset of intense apprehension, fear, terror or sense of impending doom accompanied by increased autonomic nervous system activity and by various constitutional disturbances, depersonalization and derealization.
Term
Panic Disorder
Definition
initial panic attacks develop during extreme stress. Recurrent panic attacks can occur unpredictably.
Term
OCD: Implication for PT
Definition
Give very specific guidelines for any home exercise program. How many reps, etc. for the Pt in this disorder.
Term
OCD
Definition
Recurrent, unwanted thoughts (obsessions), repetitive behaviors (compulsions) (Name the disorder)
Term
Panic Attack: S&S
Definition
Feelings of alarm and sense of impeding doom, marked dyspnea, choking/suffocate feeling, tachycardia, palpitations, headaches, dizziness are S&S in this disorder.
Term
be alert to signs of suicide and alcohol abuse.
Definition
PTSD: Name Implications for PT
Term
reassure and distract the Pt (be creative)
Definition
If a Pt experiences an anxiety or panic attack you should. . .
Term
Somatoform disorder
Definition
? Disorder: presence of physical symptoms causing impairment in social/occupational functioning.
Term
Somatoform disorder: S&S
Definition
Pain, GI problems, Depression, Dizziness. Have no identifiable physical origin. These are S&S of ? disorder.
Term
80%
Definition
Somatoform disorders make up ?% of office visits and are a large percent of PT pts.
Term
Somatoform disorder Pts
Definition
? Disorder patients often see multiple physicians & take multiple meds (polypharmacy). Do not respond well to PT & should be referred back to the physician if progress is not found.
Term
Progressive muscle relaxation, diaphragmatic breathing, exercise, biofeedback.
Definition
Stress-reducing techniques used in PT
Term
Depression
Definition
Most common MOOD disorder within at PT practice.
Term
Depression
Definition
A morbid feeling of sadness, loneliness, despair, low self-esteem, and self-reproach.
Term
Depression accompanying signs
Definition
psychomotor retardation, withdrawal from social contact, loss of appetite or over-eating, insomnia are accompanying signs in ?.
Term
Depression Implication for PT
Definition
Passive noncompliance during therapy, poor compliance in home program or post-operation rehab exercise are implications for the PT in ?.
Term
Schizophrenia
Definition
a group of disorders characterized by disruptions in thought patterns
Term
Schizophrenia S&S
Definition
Periodic outbreaks of hallucinations and delusions, fragmented thoughts, disordered speech (unintelligible, incoherent), apathy, social withdrawal, emotional unresponsiveness.
Term
Dementia
Definition
The decline or loss of cognitive and intellectual functions. Interferes with daily functions and relationships. (Name the disease)
Term
Dementia S&S
Definition
Significant decline in memory, depression, agitation or aggression, visual hallucinations, may fall frequently, problems with maintaining personal hygiene are S&S in this disease.
Term
give the Pt simple instructions and work with the caregiver.
Definition
Dementia - implications for the PT
Term
Acute Inflammation: Definition
Definition
Initial response of tissue to injury involving vascular & cellular responses.
Term
Redness, edema, warmth, pain, loss of function.
Definition
Acute Inflammation: Local Signs (name them)
Term
fever, tachycardia, hypermetabolic state, elevated serum protein, leukocytosis.
Definition
Acute Inflammation: Systemic effects (name them)
Term
Chronic Inflammation
Definition
result of persistent injury, repeated acute inflammation, infection. results in accumulation of lymphocytes, macrophages, fibrosis, loss of function.
Term
fever, malaise, fatigue, leukocytosis, ESR (erythrocyte sedimentation rate).
Definition
Chronic Inflammation: systemic effects
Term
Nutritional status, cardiovascular disease, cancer, hematologic disorders, diabetes, corticosteroids, immunosuppressants
Definition
Name the Systemic Factors influencing healing
Term
NSAIDs:
Definition
used to reduce inflammation, pain relieve and reduce fever. Adverse effects are low with most common GI upset.
Term
increase risk of bleeding to bruise easily or GI bleeding, serious reactions to CNS, blood, kidney & liver disorders.
Definition
NSAIDs risks & reactions
Term
SLE (Systemic Lupus Erythematosus)
Definition
A chronic inflammatory autoimmune dz, connective tissue dz, severe complications to the heart, kidney & CNS. Affects women 8x more than men and can be fatal.
Term
SLE S&S
Definition
Fever, weight loss, malaise, fatigue. Skin rash (butterfly/molar rash) on the neck or upper extremities.Polyarthritis (swelling joint/joint pain) and myalgias are S&S in this disease.
Term
relieve symptoms and protect organs with corticosteriods and immunosupressents.
Definition
Tx in SLE should be to . . .
Term
SLE
Definition
Recurring remissions and exacerbation. Complete remission is rare in the prognosis for ?
Term
Immunosuppressants
Definition
classes of drugs that inhibit or prevent activity of the immune system.
Term
Immunosuppressants
Definition
Glucocorticoids, Cytostatics, Antibodies are all ?
Term
prevent organ rejection, treat autoimmune diseases, treat neoplasms
Definition
Immunosuppressants are prescribed to. . .
Term
Immunosuppressants: possible severe side effects
Definition
secondary infection, renal failure are possible severe side effects of ?.
Term
Corticosteroids (Glucocorticoids such as cortisol and cortisone) are used to treat. . .
Definition
used to treat inflammation or as immunosupressants. Used to treat cancer, collagen diseases (SLE/lupus), rheumatic diseases, respiratory diseases (asthma). Using >6 months causes osteoporosis and muscle wasting. Increases risk for infection.
Term
Corticosteroids: common side effects
Definition
GI upset, Metabolic reactions (hyperglycemia, diabetes), HTN, Cushing's syndrome, increases risk for infection.
Term
Inhibit collagen synthesis
Definition
Glucocorticoids inhibit ?.
Term
Corticosteroids: Implications for PT
Definition
connective tissue damage, wound healing is slower, aseptic bone necrosis (avascular necrosis). Be conservative with stretching if patient is on long-term steroids. These are PT implications for ?.
Term
Cancer: Local effect
Definition
Tumor compresses or destroys nearby healthy tissue, necrosis, ulceration, hemorrhage are local effects of ?.
Term
Cancer: Systemic effect
Definition
General: weight loss, weakness, anemia, coagulation disorders, cachexia. Altered organ function, organ failure, secondary infection are systemic effects of ?.
Term
Cachexia
Definition
wasting factor. Pt seems like skin and bones.
Term
Chemotherapy
Definition
Inhibit DNA replication, inhibits cell division which thus inhibits tissue repair and recovery.
Term
Chemotherapy: Clinical Manifestations
Definition
Alopecia, GI symptoms of nausia & vomiting (75%), Myelosuppression (anemia, leukopenia & thrombocytopenia), Fatigue, Cardiotoxicity (renal, liver), Neuropathy (peripheral or CNS)
Term
Myelosuppression: side effects
Definition
Anemia, infection, bleeding are side effects of ?.
Term
75%
Definition
% of Pts in chemotherapy who have GI symptoms:nausea & vomiting
Term
True
Definition
TRUE/FALSE: Exercise is good for a Pt on chemo especially in later phase
Term
Dysplasia
Definition
Abnormal tissue development with a change in size, shape and organization of the cells. For example cervical.
Term
Causes of Cell Injury
Definition
Ischemia, Infectious agents, immunologic reactions, genetic factors, nutritional factors, physical agents, chemical agents are all causes of ?.
Term
Hemostatis, Inflammation, Proliferation & migration, Remodeling & maturation.
Definition
Phases of wound healing
Term
Irreversable outcomes of cell reaction to injury or stress.
Definition
Necrosis & Apoptosis
Term
Atrophy, Hypertrophy, Hyperplasia, Metaplasia, Dysplasia.
Definition
Name cell adaptations in Chronic injury
Term
Fat, Cholesterol, Protein, Glycogen and Pigments.
Definition
Intracellular Accumulations in Chronic Injury
Term
Acute Injury & Chronic Injury
Definition
Mild Cell Injury or Stress can lead to:
Term
Hydropic Degeneration
Definition
A cell reaction to Acute Injury.
Term
Pathologic Cell Dell (Necrosis)
Definition
Cell reaction to severe injury
Term
limit extent and severity of injury, eliminate or neutralize the offending agent, to initiate the repair process.
Definition
Purpose of Inflammation
Term
Factors leading to inflammation
Definition
Inadequate bloodflow, damaged tissue, cancer, infectious biologic organisms, foreign material, chemicals and physical agents (cold, heat, radiation) are all factors leading to ?.
Term
Factors affecting bloodflow
Definition
Histamine, Serotonin, Bradykinins, Anaphylatoxins, Leukotrienes/Prostaglandins are all factors effecting ?.
Term
Fibrocytes/Fibroblasts, Endothelial Cells, and Monocyte/Macrophages.
Definition
Cellular infiltrates involved in BOTH Acute & Chronic Inflammation.
Term
Platelets, Neutrophils, Monocyte/macrophage, Fibrocytes/Fibroblasts & Endothelial cells
Definition
Acute Inflammation Cellular Infiltrate
Term
Monocyte/macrophage, Lymphocytes, Plasma cells, Fibrocytes/fibroblasts & endothelial cells.
Definition
Chronic Inflammation Cellular Infiltrate
Term
Edema
Definition
Vasodilation + increased vascular permeability =
Term
C5a, Lipooxygenases products, Lymphokines, Monokines
Definition
Factors attracting and stimulating cells:
Term
WBCs (Leukocytes), RBCs and Platelets.
Definition
Circulating cells involved in the cellular response in inflammation
Term
Macrophages, Mast cells and Fibroblasts
Definition
Connective tissue cells involved in the cellular response in inflammation
Term
Fibronection, Collagen, Proteoglycans, Elastin
Definition
Extracellular Matrix involved in the cellular response in inflammation
Term
Blood coagulation cascade, Fibrinolytic system, Kinin enzymatic system, Complement System, MAC (Membrane attack complex)
Definition
Plasma Cell-derived sources in Mediators of Inflammation.
Term
Bradykinin, Hageman factor
Definition
Kinin Enzymatic system plasma cell-derived sources (name 2)
Term
C3a, C3b, C5a, C5b
Definition
Complement system plasma cell-derived sources (name 4)
Term
Circulating platelets, Tissue mast cells, basophils, polymorphonuclear leukocytes, endothelial cells, Monocytes/macrophages, injured tissue itself, Arachidonic acid derivatives and cytokines.
Definition
Cell-derived sources in mediators of inflammation
Term
Cardinal S&S of Inflammation Local Signs
Definition
Erythema (rubor/redness), Heat (calor), Edema (tumor/swelling), Pain (dolor) and Loss of Function.
Term
Cardinal S&S of Inflammation Distant Effects
Definition
Systemic effects, Involvement of the lymphatic system, Production of reactant proteins.
Term
Inflammatory Exudates (name the 5)
Definition
Hemorrhagic, Serosanguineous, Serous, Purulent and Catarrhal.
Term
Hemorrhagic (Inflammatory Exudate)
Definition
Bright red or bloody; presence of RBCs. Small amounts expected after surgery or trauma. Large amounts indicate hemorrhage. Sudden large amounts of dark red blood indicate a draining hematoma.
Term
Serosanguineous (Inflammatory Exudate)
Definition
Blood-tinged yellow or pink;presence of RBCs. Expected for 48 to 72 hours after injury or trauma to the microvasculature. A sudden increase may precede wound dehiscence.
Term
Serous (Inflammatory Exudate)
Definition
Thin, clear yellow or straw-colored; albumin and lgs. Occurs in the early stages of most inflammations (blisters, joint effusion with RA, viral skin vesicles) Expected for up to 1 week after trauma or surgery. A sudden increase indicate a draining seroma.
Term
Purulent (Inflammatory Exudates)
Definition
Viscous, cloudy, pus; necrotic cell debris and dying neutrophils. Usually caused by pus-forming bacteria (streptococci, staphyloccocci); indicates infection, may drain suddenly from an abscess (boil).
Term
Catarrhal (Inflammatory Exudates)
Definition
Thin, clear mucus. Seen with inflammatory process within mucous membranes (ex: upper respiratory infection)
Term
Acute Inflammation
Definition
Sudden onset (follows brief injury), short duration (lasts a few hours or days). Usually the result of microbial infection (bacteria, viral, etc), physical or chemical injury; immune injury
Term
Anti-inflammation Pharmaceutical Measures
Definition
Anti-histamine, Corticosteroids, NISIDs (Arachidonic Acid (AA) metabolities).
Term
Consequences of Acute Inflammation
Definition
Complete resolution, healing with scarring, abscess and chronic inflammation.
Term
Neutrophils were too strong and leave an abscess.
Definition
Abscess may form b/c ...
Term
Age effects on WBCs
Definition
WBCs don't go up as high as someone younger in an infection.
Term
Acute Inflammation Local effects on MS
Definition
ms tone/spasm, loss of motion/function. For PT: passive movement test (Cyriax).
Term
Systemic Effects (under distant effects of acute inflammation)
Definition
Fever, malaise, increase or decrease in WBCs, poor appetite.
Term
Pathogenesis
Definition
Continuing, simultaneous process of Injury, inflammation and repair.
Term
Macrophages, Lymphocytes, Plasma cells, Fibroblast cells
Definition
Inflammatory Cells involved in Chronic Inflammation (name 4)
Term
Epidermis, Bone Marrow, Liver, Kidney, GI Epithelium, Bronchial epithelium
Definition
In Wound healing these tissues are capable of regeneration:
Term
Brain (neurons), Cardiac muscle, skeletal muscle
Definition
In wound healing these tissues are NOT capable of regeneration
Term
Types of Injury Repair
Definition
Regeneration, Healing (fibrous repair or scarring) and Partial regeneration and scarring.
Term
Stable Cells
Definition
? Cells begin to regenerate only after injury.
Term
Permanent Cells
Definition
? cells cannot make new cells - only scarring.
Term
Labile Cells
Definition
? Cells are always replacing each other.
Term
Fibroblasts migration, Angiogenesis and granulation tissue, scar formation, scar maturation
Definition
Name the steps in the healing process/repair by connective tissue
Term
Primary Union (by first intention) in wound healing
Definition
Small, narrow wound. Less than a week to heal. Small scar (ex: surgical incision)
Term
Second Union (by second intention) in wound healing.
Definition
Large wound, wound edges not close together. Weeks to heal. Larger scar. (Ex: deep skin burn, ulcer, infarct, abscess)
Term
70%
Definition
A well sutured wound has ?% strength of uncut skin.
Term
10%
Definition
After suture removal at 1 week the wound strength is ?%.
Term
80%/Normal
Definition
Wound strength 3 months later is ?% and after one year is ?.
Term
Host Factors (local) interfering with wound healing
Definition
infection, poor vascular supply, foreign objects, presence of necrotic tissue, mechanical forces (movement/tension) and size of the wound.
Term
Host Factors (systemic) interfering with wound healing
Definition
poor nutrition, steroid drugs, diabetes, PVD, others (age, smoking, health status, comorbidities) are ? factors interfering with wound healing.
Term
collagen tensile/Vitamin C Deficiency
Definition
Scurvy which is a reduced ? strength is seen in ? deficiency.
Term
True
Definition
True/False: Bilateral femoral neuropathy can be seen in Vitamin C Deficiency.
Term
Vitamin C Deficiency
Definition
Osteopenia (bone pain and pathologic fractures) can be seen in this deficiency.
Term
Vitamin C Deficiency
Definition
Muscle weakness, Joint Pain and effusions and Edema can be seen in this deficiency.
Term
Vitamin C Deficiency
Definition
Impaired skin & wound healing and skin & gum lesions can be seen in this deficiency.
Term
Vitamin C Deficiency
Definition
This deficiency can cause an altered capillary structure (petechiae & hemorrhage)
Term
Keloid Formation
Definition
A hyperplastic scar that is prominent, raised, or nodular and that contains excess collagen; occurs in the dermis, usually after trauma, surgery, a burn, or severe cutaneous disease.
Term
Pyogenic Granuloma
Definition
A localized, highly vascular collection of persistent granulation tissue.
Term
Contract
Definition
If the injured region is immobilized during healing, the scar can ? resulting in an undesirable, fixed, rigid scar that can limit NROM.
Term
Type I Collagen
Definition
Type ? is a structural collagen, 80% to 85% of dermal collagen; mature scars, tendon, bone and dentin; joints.
Term
80% to 85%
Definition
Type I collagen composes ?% of dermal collagen.
Term
Type II Collagen
Definition
Type ? collagen: hyaline cartilage; not present in skin; found in nucleus pulposus external annulus.
Term
Type III Collagen
Definition
Type ? Collagen: found in vascular and visceral structures making up 15% to 20% of dermal, first collagen deposited in wound healing (granulation tissue).
Term
Type III Collagen
Definition
Name the type collagen first deposited in wound healing.
Term
15% to 20%
Definition
Type III Collagen makes up ?% of dermal, first collagen deposited in wound healing.
Term
Type IV Collagen
Definition
Type ? collagen: Basement membranes of epithelial, endothelial, glomeruli of kidney nephron.
Term
0.5 mm
Definition
The thickness of the skin over the tympanic membrane is ?.
Term
6 mm
Definition
The thickness of the skin over back, sole of foot and palm of hand is ?.
Term
True
Definition
TRUE/FALSE: The skin is thicker on the posterior/extensor surfaces as compared to the anterior/flexor surfaces of the body.
Term
Stratified Squamous Epithelium
Definition
Epidermis is made up of this type of epithelium.
Term
Stratum Corneum, Stratum Lucidum, Stratum Granulosum, Stratum Spinosum, Stratum Basale
Definition
Name the 5 layers of Epidermis
Term
Thicker
Definition
The Dermis is deep to epidermis and (? thicker/thinner) than epidermis.
Term
Sensory Organ, Temperature Regulation, Excretion, Vitamin D Production, Absorption, Protection
Definition
Name 6 Functions of the skin
Term
Sebaceous, Sweat and Mammary
Definition
Name 3 types of skin glands
Term
Hair, Nails and Glands
Definition
Name 3 specializations of the skin
Term
Tenting
Definition
One test of healthy skin is to pinch it and see if it recoils. ? occurs when the skin fails to recoil.
Term
Dehydration or normal senescent skin
Definition
Tenting is a sign of either ? or normal ? skin.
Term
Senescence
Definition
The scientific term for aging
Term
True
Definition
TRUE/FALSE: There is an increase in the risk for skin infection with very dry skin that has cracked.
Term
Types of Burns
Definition
Thermal, electrical, chemical and inhalation are all types of ?
Term
Generalized
Definition
Increase ambient temp, exercise, hyper or hypothyroidism and systemic infection (fever) can all cause a (? generalized or localized) change in temperature.
Term
DVT
Definition
Warmth, swelling and pain of an extremity may indicate ?.
Term
Hemarthrosis
Definition
Known as bleeding into a joint.
Term
Pruritis
Definition
Scientific name for itching.
Term
Decreased
Definition
Arterial occlusion, accompanied by pain, is indicative of (? increased or decreased) local blood flow.
Term
Increased
Definition
Arterial spasm or insufficiency is indicative of (? increased or decreased) local blood flow.
Term
Atrophy of skin, localized hair loss and thickening of nails, pallor or cyanosis.
Definition
Name some associated changes with chronic arterial insufficiency.
Term
Chronic Arterial Insufficiency
Definition
Atrophy of skin, localized hair loss and thickening of nails, pallor or cyanosis are all changes associated with ?
Term
Hyperkeratosis
Definition
With this skin disorder a thickening of the skin over the MCP's and PIP's occurs.
Term
Pathology
Definition
The study of the essential nature of diseases and especially of the structural and functional changes produced by them.
Term
Etiology
Definition
The cause of disease. Can be genetic, acquired or a combination of both.
Term
Pathogenesis
Definition
The mechanism of disease development. The sequence of events from the initial insult to overt signs and symptoms.
Term
Morbidity
Definition
The state of being diseased.
Term
Mortality
Definition
The state of being mortal. # of deaths/year/population
Term
Incidence
Definition
The # of new cases of a disease in a specified population during a specified period of time.
Term
Prevalence
Definition
The # of total cases of a disease existing in a given population at any given time (period of time or a particular moment in time).
Term
Sign
Definition
Any objective evidence or manifestation of illness observed by a trained clinician.
Term
Symptom
Definition
A perceptible change in the body and/or its function. Usually reported by the patient as a subjective change.
Term
Malaise
Definition
? is often the first indication of an infection or other dz.
Term
Chronic
Definition
Malaise is commonly associated with ? dz.
Term
Malaise
Definition
A feeling of general discomfort or uneasiness.
Term
Fatigue
Definition
A loss of energy. A feeling of tiredness that does not go away when you rest.
Term
Nervous
Definition
Numbling/tingling usually implies a problem with the ? system.
Term
Pain
Definition
An unpleasant sensation associated with actual or potential tissue damage and mediated by specific nerve fibers to the brain.
Term
Syncope
Definition
Loss of consciousness and postural tone.
Term
cerebral/glucose
Definition
Syncope is usually due to a decreased ? blood flow or decreased ? delivery.
Term
Dyspnea
Definition
? is a S&S usually associated with disease of the heart or lungs b/c of the shortness of breath.
Term
Dyspnea
Definition
A subjective difficulty or distress in breathing.
Term
True
Definition
It is normal during intense physical exertion or high altitude to experience Dyspnea.
Term
Dysuria
Definition
Difficulty or Pain in Urination
Term
Pallor
Definition
? is paleness of skin, lack of color
Term
Decreased blood flow/anemia
Definition
Pallor is due to ? or ?
Term
Bilirubin
Definition
Jaundice is caused by the accumulation of ? in the blood.
Term
Cholecystic
Definition
Jaundice which is a yellowish staining of the integument, sclerae and deeper tissues is a symptom of various disorders including Liver and ? diseases.
Term
Dysuria
Definition
S&S of ? can cause urinary frequency changes and alterations in sexual function that usually indicates urogenital or nervous system problems.
Term
Hemaglobin
Definition
Cyanosis is due to deficient oxygenation of ? in the blood.
Term
Cyanosis
Definition
? is a dark bluish or purplish coloration of the skin, nail beds, lips or mucous membranes.
Term
Non-Contractile Structure (ligament or tendon)
Definition
Pain during active and passive ROM implies pain from a (? contractile or non-contractile) structure.
Term
Contractile Structure (muscle)
Definition
Painful active and resisted testing without much pain during passive ROM implies injury to a (? contractile or non-contractile) structure.
Term
musculoskeletal
Definition
When symptoms change with alterations in posture, loading or movement this suggest the problem is ?
Term
may not
Definition
When the symptoms do not change with alterations in posture, loading or movement this suggests the problem (? may or may not?) be musculoskeletal.
Term
-cytosis
Definition
A condition in which there is more than the usual number of cells.
Term
thrombo- or thromb-
Definition
This prefix means blood clot; blood clotting
Term
-penia
Definition
This suffix means lack; deficiency
Term
Polycythemia
Definition
A condition characterized by an abnormal increase in the number of red blood cells in the blood.
Term
Erythrocythemia, hypercythemia, hypererythrocythemia, hyperglobulia.
Definition
Name some other terms for polycythemia
Term
Polycythemia vera
Definition
Polycythemia of unknown cause that is characterized by increase in total blood volume and accompanied by nosebleed, distension of the circulatory vessels, and enlargement of the spleen called also erythremia, erythrocythemia and Vaquez's disease.
Term
Erythrocytosis
Definition
An increase in the number of circulating red blood cells resulting from a known stimulus (such as hypoxia).
Term
Complete Blood Count
Definition
One of the most common labs is a CBC which stands for ?
Term
Basic Metabolic Panel
Definition
One of the most common labs done is a BMP which stands for ?
Term
Brain Natriuretic Peptide
Definition
BNP is a common lab test which stands for ?
Term
International Normalized Ratio
Definition
INR is a common lab test which stands for ?
Term
D-Dimer
Definition
A common lab test used to assist in the dx of blood clots is a ?
Term
Troponin
Definition
A common lab test used to assist in the dx of a heart attack is a ?
Term
fight infection
Definition
The major function of WBC is to ?
Term
RBC Count
Definition
Actual # of red blood cells per volume of blood.
Term
Mean Corpuscular Volume (MCV)
Definition
is a measurement of the average size of your RBCs.
Term
RBCs
Definition
The MCV is elevated when ? are larger than normal (macrocytic).
Term
Vitamin B12
Definition
Anemia caused by ? deficiency can cause RBCs to be larger than normal resulting in an elevated MCV.
Term
iron deficiency/Thalassemia
Definition
In Anemia caused by ? deficiency or ?, RBCs are smaller than normal resulting in a decreased MCV.
Term
Mean Corpuscular Hemoglobin (MCH)
Definition
? is a calculation of the avg amount of oxygen-carrying hemoglobin inside a red blood cell.
Term
higher
Definition
Macrocytic RBCs are large and tend to have a (?higher or lower?) MCH value.
Term
lower
Definition
Microcytic RBCs are small and tend to have a (? higher or lower ?) MCH value.
Term
Mean Corpuscular Hemoglobin Concentration (MCHC)
Definition
? is a calculation of the average concentration of hemoglobin inside a red cell.
Term
WBC, Hematocrit, Hemoglobin, Platelets
Definition
A CBC (complete blood count) measures 4 things: name them
Term
Hematocrit
Definition
This measures the percentage of red blood cells/volume of blood.
Term
Hemoglobin
Definition
? measures the actual amount of oxygen carrying protein in the blood.
Term
WBC Count as part of a CBC
Definition
Measures the actual number of leukocytes/volume of blood.
Term
RDW (Red Cell Distribution)
Definition
? is a calculation of the variation in the size of RBCs.
Term
Anisocytosis
Definition
? is the term for the amount of variation in RBC size.
Term
Poikilocytosis
Definition
Is the term for variation in shape of a RBC.
Term
Pernicious Anemia
Definition
In ? anemia the amount of variation in RBC size with variation in shape causes an increase in RBC.
Term
Hypochromia
Definition
Term meaning the hemoglobin is abnormally diluted inside the RBCs.
Term
Iron/Thalassemia
Definition
Decreased MCHC values (hypochromia) are seen in ? deficiency anemia and in ?.
Term
Hyperchromia
Definition
Term meaning the hemoglobin is abnormally concentrated inside the RBCs.
Term
burn/spherocytosis
Definition
Increased MCHC values (hyperchromia) are seen in ? patients and hereditary ? (a rare congenital disorder).
Term
WBC Count
Definition
Measures the number of white blood cells per cubic centimeter of blood.
Term
4,500 to 11,000
Definition
What are the normal WBC values for adult males/females?
Term
Leukocytosis
Definition
Term used to describe an increase in WBC >11,000.
Term
Fever
Definition
It is important to exercise caution when treating patients with elevated WBC > 11,000 and accompanied by ?
Term
True
Definition
True/False: Remember that the elderly may have elevated WBC with no fever but have significant change in functional status.
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