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Details

Pathology
neoplasms of the bone
7
Medical
Graduate
10/25/2007

Additional Medical Flashcards

 


 

Cards

Term
Osteoma
Definition

·         Benign neoplasm of skull & facial bones that could progress to “hyperostosis frontalis interna”

·         Is associated with Gardner syndrome

o   AD (APC gene; 5q)

o   Benign bone neoplasm(s)

o   Multiple polyposis predisposing to colon carcinoma

o   Epidermoid cysts & fibromas

Term
Chondrosarcoma
Definition

·         Malignant tumor typically affecting the pelvic bones, spine, and shoulder girdle

·         Neoplastic hyaline & myxoid cartilage formation that permeates throughout the madullary cavity, grows through the cortex of the bone, and forms a relatively well-circumscribed soft tissue mass

·         Average age of onset 30 – 60 years

Term

Osteosarcoma (oseogenic sarcoma)

Definition
  • Most common primary malignant tumor of the bone
  • Age of onset 10 - 25 years
  • Classic X-ray findings
    • Codman's triangle
    • Sunburst pattern reactive bone formation
  • Commonly involves metaphyses of long bones (MC knee)
Term
Osteoid osteoma
Definition
  • Benign but painful neoplasm of cortex of the long bones (MC knee) smaller than 2 cm with round radiolucency with central mineralization and a dense sclerotic rim 
  • Pain, that is worst @ night, is responsive to NSAIDs
Term
Osteoblastoma
Definition
Same as osteoid osteoma but > 2 cm that often involves the vertebrae
Term
Osteochondroma (exostosis)
Definition
  • Benign outgrowth of epiphyseal growth plate with marrow, bone, and cartilage cap
  • Rare after closure of metaphyseal growth plate
Term
Osteoclastoma
Definition
  • Uncommon bone neoplasm, affecting females more than the males, characterized by multinucleated giant cells within normal stromal cells
  • Knee
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