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Pathology
Neoplasia
114
Pathology
Graduate
01/17/2014

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Cards

Term
cytokines for angiogenesis
Definition
FGF, VEGF
Term
hallmarks of cancer
Definition
evading apoptosis, self-sufficiency in growth signals, insensitivity to anti-growth signals, angiogenesis, limitless replicative potential, tissue invasion and metastasis
Term
how CA invades the basement membrane
Definition
collagenases and hydrolases
Term
theory of metastasis
Definition
seed and soil
seed= tumor embolus
soil = target organ
Term
hyperplasia
Definition
increased number of cells
Term
metaplasia
Definition
one adult cell type is replaced with another
Term
dysplasia
Definition
loss of cellular orientation, shape and size
Term
anaplasia
Definition
abnormal cells lacking differentiation, resemble primitive cells
Term
neplasia
Definition
clonal proliferation of cells
Term
desmoplasia
Definition
fibrous tissue formation in response to neoplasm
Term
tumor grade
Definition
based on histologic appearance
Term
tumor staging
Definition
degree of localization/spread based on site and size of primary lesions; TNM= tumor, node, metastases
Term
epithelium
- benign
- malignant
Definition
- adenoma, papilloma
- adenocarcinoma, papillry carcinoma
Term
blood vessels
- benign
- malignant
Definition
- hemangioma
- angiosarcoma
Term
blood cells
- benign
- malignant
Definition
- none
- leukemia/lymphoma
Term
smooth mm
- benign
- malignant
Definition
- leiomyoma
- leiomyosarcoma
Term
skeletal mm
- benign
- malignant
Definition
- rhabdomyoma
- rhabdomyosarcoma
Term
CT
- benign
- malignant
Definition
- fibroma
- fibrosarcoma
Term
bone
- benign
- malignant
Definition
- osteoma
- osteosarcoma
Term
fat
- benign
- malignant
Definition
- lipoma
- liposarcoma
Term
> 1 cell type
- benign
- malignant
Definition
- mature teratoma (women)
- mature teratoma (men), immature teratoma
Term
benign vs malignant
Definition
benign= well-differentiated, slow growing, well demarcated
malignant= poorly differentiated, erratic grown, invades local tissues, metastasis
Term
cachezia definition
Definition
loss of weight, muscle atrophy and fatigue with chronic disease
Term
cachexia cytokines
Definition
TNF-alpha, IFN-gamma, IL6
Term
what neoplasm is associated with down syndrome
Definition
ALL and AML
Term
what neoplasm is associated with xeroderma pigmentosum and albinism
Definition
melanoma, BCC, SCC of skin
Term
what neoplasm is associated with chronic atrophic glossitis
Definition
gastric
Term
what neoplasm is associated with pernicious anemia
Definition
gastric
Term
what neoplasm is associated with tuberous sclerosis
Definition
astrocytoma, angiomyolipoma and cardiac rhabdomyoma
Term
what neoplasm is associated with actinic keratosis
Definition
SCC of skin
Term
what neoplasm is associated with barrett
Definition
esophageal adenocarcinoma
Term
what neoplasm is associated with plummer-vinson
Definition
SCC of esophagus
Term
what neoplasm is associated with cirrhosis
Definition
hepatocelullar
Term
what neoplasm is associated with ulcerative colitis
Definition
colonic
Term
what neoplasm is associated with pagets
Definition
osteosarcoma and fibrosarcoma
Term
what neoplasm is associated with immunodeficiency states
Definition
lymphomas
Term
what neoplasm is associated with AIDS
Definition
lymphoma, kaposi
Term
what neoplasm is associated with autoimmune
Definition
lymphomas
Term
what neoplasm is associated with acanthuses nigricans
Definition
visceral malignancy
Term
what neoplasm is associated with dysplastic nevus
Definition
malignant melanoma
Term
what neoplasm is associated with radiation
Definition
leukemia, papillary thryoid CA
Term
what neoplasm is associated with achalasia
Definition
SCC of esophagus
Term
what neoplasm is associated with sjogrens
Definition
b cell lymphoma
Term
abl
Definition
CML
Term
c-myc
Definition
burkitt
Term
bcl-2
Definition
follicular
Term
erb-B2
Definition
breast, ovarian and gastric
Term
RAS
Definition
colon
Term
l-myc
Definition
lung
Term
n-myc
Definition
neuroblastoma
Term
RET
Definition
MEN IIA and IIB
Term
c-kit
Definition
gastric stromal tumor
Term
Rb
Definition
reinoblastoma and osteosarcoma
Term
p53
Definition
most cancers
Term
BRCA1
Definition
breast and ovarian
Term
BRCA2
Definition
breast cancer
Term
p16
Definition
melanoma
Term
APC
Definition
colorectal (FAP)
Term
WT1
Definition
wilms'
Term
nf1
Definition
neurofibromatsis type I
Term
NF2
Definition
neurofibromatosis type 2
Term
DPC
Definition
pancreatic
Term
DCC
Definition
colon cancer
Term
tyrosine kinase increased in what cancers?
Definition
abl, erbB2, RET
Term
transcription factor with cancers
Definition
c-myc, l-myc, n-myc, c-KIT
Term
GTPase cancer
Definition
RAS
Term
PSA
Definition
prostatic carcinoma, BPH and prostatisis
Term
prostatic acid phosphatase
Definition
prosate
Term
CEA
Definition
colorectal and pancreatic
Term
AFP
Definition
heptocellular, yolk sac tumor
Term
beta-hCG
Definition
hydatidiform mole, choriocarcinoma, gestational trophoblastic tumors
Term
CA-125
Definition
ovarian
Term
S100
Definition
melanoma, neural tumors, astrocytomas
Term
alk phos
Definition
met to bone, patents, obstructive biliary disease
Term
bombesin
Definition
neuroblastoma, lung and gastric
Term
TRAP
Definition
hairy cell leukemia
Term
CA-19-9
Definition
pancreatic
Term
calcitonin
Definition
medullary thyroid
Term
THLV-1
Definition
adult t cell leukemia/lymphoma
Term
HBV/HCV
Definition
hepatocellular
Term
EBV
Definition
burkitt, hodgkin, nasopharyngeal
Term
HPV
Definition
cervical, penile, anal, vulvar
Term
HHV8
Definition
kaposi sarcoma, B cell lymphoma
Term
HIV
Definition
CNS lymphoma
Term
H pylori
Definition
gastic adenocarcinoma and lymphoma
Term
schistosoma haematobium
Definition
SCC of bladder
Term
strep bovis
Definition
colonc ancer
Term
C. sinensis
Definition
cholangiocarcinoma
Term
aflatoxin
Definition
hepatocellular
Term
vinyl chloride
Definition
angiosarcoma in liver
Term
CCL4
Definition
centrilobular necrosis, fatty change
Term
nitrosamines
Definition
gastric cancer and SC esophageal
Term
cigarette smoke
Definition
SCC laynx, lung, small cell lung, renal cell CA, transitional cell CA bladder
Term
asbestos
Definition
mesothelioma and bronchogenic CA
Term
arsenic
Definition
SCC skin, angiosarcoma
Term
naphtalene
Definition
SCC bladder
Term
akylating agents
Definition
leukemia
Term
paraneoplastic ACTH
Definition
small cell lung
Term
paraneoplastic ADH
Definition
small cell lung and intracranial
Term
paraneoplastic PTH
Definition
squamous cell lung, renal cell and breast
Term
paraneoplastic TGF-beta
Definition
SCC lung, renal cell, breast
Term
paraneoplastic TNF
Definition
SCC lung, renal cell, breast
Term
paraneoplastic IL1
Definition
SCC lung, renal cell, breast
Term
paraneoplastic EPO
Definition
renal cell, hemangioblastoma, hepatocellular, pheochromocytoma
Term
paraneoplastic Ab to presynaptic Ca
Definition
thymoma, small cell lung
Term
paraneoplastic hyperuricemia
Definition
leukemias and lymphomas
Term
psammoma bodies
Definition
papillary thyroid, serous papillayr cystadenocarcinoma of ovary, meningioma, malignant mesothelioma
Term
male Ca incidence
Definition
prostate > lung > colon
Term
female Ca incidence
Definition
breast > lung > colon
Term
male Ca mortality
Definition
lung > prostate > colon
Term
female CA mortality
Definition
lung > breast > colon
Term
metastases to brain
Definition
lung > breast > skin > kidney > GI
Term
metastasis to liver
Definition
colon > stomach > pancreas > breast > lung
Term
metastasis to bone
Definition
prostate > testes/thyroid > breast > lung > kidney
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