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Pathology Unit V
Female Reproductive Tract: Cervix
16
Pathology
Graduate
03/06/2013

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Term
acute cervicitis definition
Definition
inflammatory conditions of the cervix
Term
chronic cervicitis definition
Definition
inflammatory conditions of the cervix
Term
which is more common acute or chronic cervicitis
Definition
chronic
Term
Three causes of acute and chronic cervicitis
Definition
C. trachomatis, U. urealyticum, and T. vaginalis
Term
Nabothian cysts definition
Definition
mucus filled lumps, metaplastic, can lead to chronic cervicitis
Term
what infectious process is thought to be related to the development of follicular cervicitis?
Definition
Chlamydia
Term
incidence of endocervical polyps.
Definition
common inflammatory tumors that occur in 2 to 5% of adult women, usually in the fourth and fifth decades of life
Term
gross features of endocervical polyps.
Definition
loose fibromyxous stroma, mucus secreting glands
Term
clinical significance of endocervical polyps.
Definition
They are frequently associated with chronic cervicitis. Clinically they cause bleeding or spotting.
Term
progressive steps of intraepithelial neoplasia from mild dysplasia to carcinoma in situ.
Definition
Mild dysplasia -> moderate dysplasia -> severe dysplasia -> carcinoma in situ.
Term
relationship of cervical dysplasia and CIN to invasive squamous carcinoma
Definition
high-risk HPV infection can lead to invasive carcinoma
Term
incidence of cervical carcinoma
Definition
45 years old
Term
etiology of cervical carcinoma
Definition
precursor CIN
Term
pathogenesis of cervical carcinoma
Definition
HPV exposure  CIN  higher grade CIN  invasive carcinoma  metastasis
Term
clinical course of cervical carcinoma
Definition
Prognosis of patients with carcinoma of the cervix is largely dependent on the stage of disease at time of diagnosis. At Stage 0 (carcinoma in situ) cure is virtually 100%. At Stage I (carcinoma confined to the cervix) there is an 85 to 90% five-year survival rate. At Stage II, a 70 to 75% five-year survival rate. At Stage III, a 35% five-year survival rate. At Stage IV, a 10% five-year survival rate. Patients with extensive disease often die of uremia due to local extension of tumor, causing obstruction of ureters and subsequent pyelonephritis
Term
Subtypes of Human Papilloma Virus thought to be associated with intraepithelial and cervical invasive neoplasia
Definition
type 16 and 18
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