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a localized area of ischemic necrosis in an organ or tissue resulting from sudden reduction of either its arterial supply or venous drainage |
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General morphology of infarcted organs |
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Definition
classified on basis of color (reflecting amount of hemorrhage) and the presence or absence of microbial infection: Red or White, Septic or Bland |
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occur with venous occlusions, loose tissues, tissues with duel circulation, previously congested tissues, and when flow is reestablished after infarction has occurred |
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occur with arterial occlusions in solid organs with end-arterial circulations, where tissue density limits the seepage of blood from adjoining patent vascular beds |
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infected cardiac valve vegetations embolize, or when microbes seed necrotic tissue, infarct becomes an abscess with a greater inflammatory response |
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absence of bacterial involvement |
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Factors affecting severity of injury due to infarction |
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Definition
general status of the blood and the cardiovascular system, the anatomic pattern of the vascular supply of the tissue involved (single versus dual/anastomosing blood supply), the rate of development of the occlusion, the vulnerability of the tissue to ischemia. |
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clinical significance of infarcts as a cause of death |
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Definition
40% of all deaths in the US are a consequence of cardiovascular disease, with most of these deaths stemming from myocardial or cerebral infarction |
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cardiovascular collapse due to severe cardiogenic, hypovolemic or septic disease |
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Causes of shock include all of the following EXCEPT |
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Shock as a result of hypovolemia is LEAST likely to occur with |
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White infarcts are encountered in all EXCEPT |
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Red infarct is seen in all EXCEPT |
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cardiogenic, hypovolemic, and septic |
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