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Pathology Unit II
Embolism
14
Pathology
Graduate
01/27/2013

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Term
Embolus
Definition
a detached intravascular solid, liquid, or gaseous mass that is carried by the blood to a site distant from its point of origin. 99% of all emboli arise in thrombi(thromboembolism).
Term
Embolism
Definition
dislodged embolus
Term
Pulmonary Embolism
Definition
Thrombi from DVT fragments are carried through the heart to the pulmonary vasculature. third most common acute cause of death in the United States (follows heart attacks and strokes). Over 95% arise in thrombi within the large deep veins of the lower legs.
Term
Clinical Significance of Pulmonary Embolism
Definition
patients who've had one PE are at risk for another
Term
Systemic Embolism
Definition
refers to emboli that travel through the arterial circulation. 80 to 85% arise from thrombi within the heart. The major sites of lodgment are the lower extremities (70 to 75%), the brain (10%), visceral arteries (10% - includes mesenteric, renal, and splenic), and the upper limbs (7 to 8%).
Term
Clinical Significance of systemic embolism
Definition
most common form of emboli
Term
Air or Gas embolism
Definition
occurs in persons exposed to sudden changes in atmospheric pressure. When air is breathed under high pressure, increased amounts of the inspired gases dissolve in the blood, tissues, and fat.(Nitrogen is very soluble in fat.) If the individual decompresses too quickly the dissolved oxygen, carbon dioxide, and nitrogen will come out of solution as minute bubbles. The oxygen and carbon dioxide will be rapidly reabsorbed, but the nitrogen, which has low fluid solubility, may remain as tiny bubbles or may coalesce to form large masses of gas within the blood vessels and tissues.
Term
Clinical Significance of Air/Gas Embolism
Definition
neurosurgery performed in the sitting position can occlude flow, scuba diving "the bends", acute decompression sickness
Term
Fat Embolism
Definition
follows fracture of bones containing fatty marrow, or after severe trauma to adipose tissue.
Term
Clinical Significance of Fat Embolism
Definition
can be fatal in 10% of cases
Term
Amniotic Fluid Embolism
Definition
components of amniotic fluid(epithelial squames, vernix caseosa, and sometimes mucus and lanugo hairs) enter the maternal circulation.
Term
Clinical Significance of Amniotic Fluid Embolism
Definition
uncommon, grave complication of labor, mortality rate is 80% for mothers, most common cause of maternal death
Term
The most common source of a pulmonary embolism is
Definition
Deep Vein Thrombosis proximal to the popliteal fossa
Term
The most common source of a systemic embolism is
Definition
intracardiac mural thrombi
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