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Pathology of Infections II
Lecture 10
25
Medical
Graduate
04/06/2011

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Cards

Term
definition of polioencephalitis, leukoencephalitis, myelitis
Definition
infection of gray matter, white matter, and spinal cord
Term
general pathological features of viral infections (5)
Definition
perivascular cuffing, neuronophagia, microglial nodules, inclusion bodies, mononuclear inflammation
Term
Cowdry type A; ddx?
Definition
herpes, SSPE
Term
CSF profile in viral infection
Definition
clear fluid, PMN infiltrate then lymphocyte infiltrate, elevated protein, normal glucose
Term
hemorrhagic necrotizing encephalitis; ddx?
Definition
herpes, filovirus, CMV
Term
olfactory and temporal lobe seizures; dx?
Definition
herpes encephalitis
Term
latency location for..
1. HSV1
2. HSV2
Definition
1. trigeminal ganglion
2. sacral ganglia
Term
chronic demyelination at gray-white junction; dx?
Definition
PML
Term
purple oligodendroglia, basophilic inclusions, bizarre astrocytes; dx?
Definition
PML
Term
agent causing PML
Definition
polyomavirus > JC virus = Papova virus
Term
marker for extent of HIV dementia
Definition
neuroinflammation (not viral load)
Term
increase white matter signal on MRI, CD4+ giant cells, perivascular cuffing; dx?
Definition
HIV encephalitis
Term
spaghetti-like strands within nuclei; dx?
Definition
paramyxoviridae (rubeola)
Term
encephalitis with high risk of fatality (3)
Definition
SSPE, PML, TSE
Term
late symptoms are meningismus, stupor, coma, and death; incubated 1-3mo; dx?
Definition
rabies
Term
tropism for rabies
Definition
pyramid cells of hippocampus, Purkinje cells of cerebellum
Term
most common TSE
Definition
CJD
Term
1. median age for CJD
2. age range for vCJD
Definition
1. 68yo
2. younger (adults)
Term
clinical presentation of vCJD
Definition
behavioral psychiatric disorders instead of neurologic symptoms, slower progression, younger age of onset
Term

[image]

dx?

Definition
vCJD
Term
iatrogenic causes of TSE (4)
Definition
corneal transplant, dural transplant, growth hormone, electrodes
Term
pathogenesis of FFI
Definition
Met129 polymorphism + D178N mutation
Term
CJD pathogenesis
Definition
Val129 polymorphism + D178N mutation
Term
tropism for vCJD
Definition
thalamus
Term
tropism for sCJD
Definition
anterior basal ganglia
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