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Morphological Diagnosis: Multifocal Acute Moderate Ruminitis Distribution: Multifocal Severity: Severe? Process: Inflammatory, infectious- Mycotic/fungal species such as Mucor, Aspergillus, Rhizopsus, and absidia species causes circular and well delineated infarction and thrombosis |
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Diagnosis: Bloat Line Process: Indicates that the cow could not eructate, leading to the buildup of gas within the rumen and the susequent compression of the esophagus, leading to ischemia |
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Nutmeg appearance due to Chronic Passive Congestion Chronis |
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Chronic Passive Congestion with Nutmeg Appearance Chronic |
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Cirrhosis- presence of regenerative nodules separated by fibrous septa due to chronic hepatitis Severe |
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Process: deposition of fibrin, pyogranulomatous inflammation, or edema - Feline infectious peritonitis- Coronavirus |
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Process: Fibrosis takes place in responses to chronic inflammation -Chronic Diagnosis: Chronic Moderate Multifocal Hepatic Fibrosis |
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Lesions in the lover often develop secondary ruminal acidosis or rumenitis. Most likely diagnosis: Hepatic abscesses caused by Fusobacterium necrophorum infection or by Corynebacterium spp |
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Condition: Hepatic Lipidosis DAMNITV: Metabolic, Degenerative, Nutritional Chronic |
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Herniation - Rent in the mesentery with the intestines displaced through the rent |
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Intussusception - telescoping of intestine inside intestine |
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Johne's disease - Granuloma/granulomatous hyperplasia - Granulomas of the intestines and thickening of the mucosal folds caused by Mycobacterium avium |
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DAMNITV: Neoplastic Diagnosis: Lymphoma Distribution: Multifocal Severe and Chronic |
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Metabolic Bone Disease - Pathogenesis: calcium/phosphorous imbalance in the body (commonly due to a vitamin D deficiency) which causes a weakening if the skeletal structure via increased activity of the parathyroid gland to mobilize calcium from bone tissue |
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White spots are from necrosis Organs present: Liver, lungs, heart, diaphragm, jejunum/intestines |
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Lesion- Nodular hyperplasia |
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Distribution: Focal Differential: Pancreatic Adenocarcinoma |
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Parakeratosis - Diet that maintains a high grain concentration leads to the rapid production of volatile fatty acids, which lowers the pH of the rumen. Lower pH promotes the proliferation of lactic acid-producing bacteria which further lower the pH. In a chronic fashion, low pH promotes the compensatory keratinization of ruminal papillae to prevent damage and also decreases absorption across the ruminal epithelium. Chronic |
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DAMNITV: Neoplastic Process (note color of jejunum): Pedunculated Lipoma causing strangulation and occlusion of blood supply in a horse |
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Adrenal Gland Medulla affected Pathology: Pheochromocytoma |
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Pituitary gland adenoma Secondary diseases: hyperadrenocorticism and hyperthyroidism What happens to the surrounding tissue? Compression atrophy |
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Morphological Diagnosis: Diffuse Severe Subacute to Chronic Proliferative Enteritis with Hemoorhage Organism involved= Lawsonia intracellularis Lesion: Markedly thickened mucosa throughout the section with a blood clot (red bloody cast) |
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Organ: Pancreas Acute- Saponification/Fat Necrosis |
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Process: Saponification- trauma to the pancreas or acute pancreatitis leads to acinar cell damage which leads to the release of lipases, resulting in degradation of triglycerides into fatty acids. Free fatty acids accumulate with salt and calcium to form deposits throughout the tissue |
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Etiological Diagnosis: Bacterial Dermatitis or Erysipelas Dermatitis Process: Hemorrhage or Ischemia and Necrosis (Skin Infarcts) |
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Etiological Diagnosis: Bacterial Dermatitis or Erysipelas Dermatitis Process: Hemorrhage or Ischemia and Necrosis (Skin Infarcts) |
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Intestine from pig DAMNITV: Infectious, Inflammatory Disease: Brachyspira hyodysenteriae |
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Morphological Diagnosis: Diffuse Severe Subacute to Chronic Proliferative Enteritis with hemorrhage Organism: Lawsonia intracellularis Describe Lesion: Markedly thickened mucosa throughout the section with a blood clot (red bloody cast) -Proliferative Enteritis |
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Thyroid Carcinoma which causes hypothyroidism in dogs |
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Torsion or Volvulus of the large colon Sequestra: Ischemia occurs due to the compression of both arteries and veins, obstruction, bloat, pain Species: horse |
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Unilateral adrenal cortical adenoma How does this impact the other adrenal gland? Cortical atrophy of contralateral gland |
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Unilateral thyroid adenoma DAMNITV: Neoplastic, degenerative, metabolic |
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Diffuse Hyperplastic Goiter - Both lobes of thyroid are uniformly enlarged (mostly young animals) |
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Colloid Goiter - Hyperplastic follicular cells continue to produce colloid but endocytosis of colloid is decreased from low pituitary TSH -Bilateral diffuse enlargement but paler in color and translucent due to macrofollicles filled with colloid |
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Inherited Dyshormonogenetic Goiter - Autosomal recessive trait -Common in goats and young animals -Inability to synthesize and secrete adequate amounts of thyroid hormones - Symmetric enlargement of thyroids at birth due to intense hyperplasia of follicular cells |
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Inherited Dyshormonogenetic Goiter - Autosomal recessive trait -Common in goats and young animals -Inability to synthesize and secrete adequate amounts of thyroid hormones - Symmetric enlargement of thyroids at birth due to intense hyperplasia of follicular cells |
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Nodular Hyperplasia Older animals - Multiple white-tan nodules of varying size - Poorly to non encapsulated; do not cause compression of adjacent parenchyma |
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White to tan - Tend to be solitary, small - Well encapsulated - Can cause compression due to expansile growth but thyroid gland only moderately enlarged or distorted |
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White to tan - Tend to be solitary, small - Well encapsulated - Can cause compression due to expansile growth but thyroid gland only moderately enlarged or distorted |
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Follicular Cell Carcinoma -Can be uni/bilateral -Most palpable near larynx - Can cause respiratory distress if impinged on larynx and trachea -Not freely movable |
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Dogs get thyroid carcinoma more than adenomas Cats get adenomas more than carcinoma |
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Diffuse cortical hyperplasia -hypertrophy and hyperplasia of zona fasiculata and zona reticularis in reponse to autonomous hypersecretion of ACTH by a corticotroph adenoma of pituitary gland |
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- Occur most frequently in older dogs - Usually single, unilateral, well demarcated - Larger ones are yellow to red and distort contour of the gland |
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Well defined spherical nodules in the cortex or attached to the capsule -Hyperplastic nodules are usually multiple, bilateral, yellow |
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Adenoma of adrenal cortex - Usually unilateral; arise from cortex - Usually circumscribed but incompletely encapsulated; grow by expansion |
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Cortical adenomas and carcinomas - Cause severe atrophy of contralateral adrenal |
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Hyperpigmentation- excess of pituitary melanocyte-stimulating hormone that develops due to decrease of inhibitory adrenocortical hormone Addison's disease |
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Adrenal Pheochromocytoma - Dark reddish brown; variegated due to areas of hemorrhage and necrosis - Single to multiple -Incomplete encapsulated - Lipofuscin may be seen at periphery tumor - Some secrete epi/norepi |
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Adrenal Pheochromocytoma invasion of the vena cava |
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