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Pathology Exam 2 Musculoskeletal Neoplasms and infectious Di
exam 2
38
Pathology
Graduate
08/01/2016

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Term
bed rest versus aging on physical work capacity
Definition
3 weeks of bed rest has greater impact than 30 years of aging
Term
musculoskeletal injury
gender considerations
Definition
-women 2x rate of injury during ovulation
-Men build muscle 2x as fast
Term
aging on musculoskeletal systemq
Definition
-strength loss (sarcopenia)
Term
aging strength loss
pathogenesis
Definition
-Inactivity
-Nutrition
-Metabolic and Endocrine changes – dec testosterone
-Decreased Neuromuscular connectivity
-Muscle Function
Term
sarcopenia
Definition
age related loss of muscle mass , strength and endurance, changes in metabolic quality
Term
factors leading to sarcopenia
Definition
-endocrine
-neurodegenerative disease
-nutrition/malabsorption
-age (hormonal,
-disuse
-cachexia
Term
joint and connective tissue and aging
Definition
-Increased stiffness and decreased flexibility
-Changes in articular cartilage
-Tendons
-Proprioception
-Bone (loss)
Term
general strengthening guideline
Definition
3 sets, 10-12, should be tired after each set
Term
osteomyelitis
-what?
-incidence
Definition
Infectious organism in the bone
more common in adults and immunocompromised
Term
types of Osteomyelitis
Definition
Exogenous (direct invasion to bone )
Hematogenous (preexisting infection that spreads to bone )
Term
initial infection of bone
Definition
-Common near Metaphysis (porous) secondary to highly vascular
-Lack of pain fibers in cancellous bone
Term
stages of osteomyelitis
Definition
-----1st stage-----
Destruction of bone
Abscess
Necrosis (cut off blood supply)
Pain when spread to periosteum

---------second stage-------
pus grows, destroying bone
Term
osteomyelitis diagnosis
Definition
mri, xray, bone scan
Term
osteomyelitis prevention
Definition
antibiotics
Term
osteomyelitis treatment
Definition
Antibiotics ( biopsy)
Amputation
Term
osteomyelitis rehab concerns
Definition
-NWB
-Immobility ( avoid contractures)
-Prevention- ext fixators, wound care
Term
exercise effect on bone
Definition
increases density
Term
infections of prosthesis and implants
Definition
low incidence
-risk: immunocompromised
-prevent: prophylactic antibiotics
-
Term
diskitis
-what is it?
Definition
infection of the disk or vertebral end plates
Term
diskitis
-causes
Definition
-post discectomy
-hematogenous, spread from blood
Term
diskitis
-symptoms
Definition
-lower and upper back pain/stiffness/
-abdominal pain
-posture changes
-fever
Term
diskitis
-diagnosis
-treatment
Definition
-bone scan, xray, mri
-antibiotics, antiinflamm, support, surgery
Term
infectious or septic arthritis
-causes
Definition
infected joint
-from blood(hematogenous), penetrating object, or nearby infection
Term
infectious or septic arthritis
-patogenesis
Definition
-presence of lysosomes and exotoxins
-pannus - inflammatory exudate
-erosion joint <3 weeks
Term
infectious or septic arthritis
-symptoms
Definition
-Not able to move the limb with the infected joint (pseudoparalysis)
-Severe joint pain
-Joint swelling
-Joint redness
-Fever
Term
infectious or septic arthritis
-management
Definition
-aspiration of fluid
-rest, elevation of the joint, ice, compression.
-exercise once healing begins
Term
inflammation in the muscle
Definition
myositis
Term
myositis
-causes and diagnosis
Definition
-infection,(viral, bacterial, parasite)
-strong link with cancer
--DIAGNOSED through history and muscle biopsy
Term
myositis
-symptoms
Definition
malaise
swelling
fever
lethargy
atrophy
tenderness
Term
myositis
-treatment
Definition
immunosuppressants
-anti-inflammatory
Term
Skeletal TB
-pathogenesis
Definition
-infection spread from the lungs
-usually to the spine
-AIDS risk factor
Term
skeletal TB
-treatment
Definition
-medications
-surgical debridement
-amputation
Term
neoplasm
Definition
new or abnormal growth of cells
Term
musculoskeletal neoplasm types
Definition
-malignant
-benign
Term
Bone tumors
-incidence
-common type
-treatment factors
Definition
-99% benign
-osteochondroma is common type
-treatment depends on if it is problematic
Term
malignant bone neoplasms
-common cause and types
Definition
-metastasizes from other cancer
-multiple myeloma and osteosarcoma are common
Term
malignant bone neoplasms
-signs
Definition
-deep pain, unremitting, night pain, weight loss, pain without trauma
Term
bone neoplasms rehab considerations
Definition
-early mobilization
-avoid torsion, high impact
-stretching
-balance
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