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Pathology Exam 1 lecture 6
The gastrointestinal system
28
Pathology
Graduate
07/19/2016

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Term
upper GI tract
Definition
-mouth
-esophagus
-stomach
-duodenum
-aids in the ingestion and digestion of food
Term
Lower GI tract
Definition
-Small and Large intestine
Term
small intestine
Definition
accomplishes digestion and absorption of nutrients
Term
large intestine
Definition
absorbs water and electrolytes, stores waste products of digestion until elmination
Term
gut immune system
Definition
-has 70-80% of the body's immune cells
-reduction of normal bacteria in the gut after using antibiotics may interfere with immune function
Term
restoring the gut flora
-options and success rates
Definition
-Vancomyacin - 60% cure rate
-donor stool sample - 90% cure rate
Term
signs and symptoms of GI disease
Definition
-fatigue
-malaise
-fever
-diaphoresis
-urgency
-cramps
-gas
-nausea
-diarrhea
-constipation
-dysphagia
-heartburn
-pain
-bleeding
-incontinence
Term
Hiatal hernia
-types and causes
Definition
-congenital: failure or fusion of developmental components of the diaphagm
-acquired: penetrating wounds, blunt trauma, or persistent pressure (coughing, straining, vomiting)
Term
Gastroesophageal reflux diseasse
Definition
esophagitis, caused by lower esophageal sphincter dysfunction
Term
causes of lower esophageal sphincter dysfunction and subsequent GERD
Definition
-reflux of infectious agents
-chemical irritants
-physical agents such as radiation
-nasogastric intubation
-gastric juices
Term
most common type of esophagitis/GERD
-population statistics
Definition
reflux esophagitis, with return flow of the stomach and duodenal contents into the esophagus
-15% or more of the population has daily symptoms of GERD
-1/3 of the population has monthly symptoms
Term
symptoms of reflux esophagitis
Definition
-heartburn, reflux, belching, dysphagia, and painful swallowing. BURNING SENSATION
-mostly 30-60 minutes after a meal
Term
GERD aggravating factors
Definition
recumbency
bending
meals
Term
GERD relief strategies
Definition
-antacid/baking soda
- standing and walking
- fluids
- remaining upright for at least 3 hours after meals
- elevation of head of bed
- sleep on the left side with a pillow in place to maintain this position
Term
GERD treatment
Definition
-surgery to repair the lower esophageal sphincter
-anti-acids
-the shaker head lifting exercise
Term
acute gastritis
Definition
-irritated stomach
-caused by NSAIDS, diet, ETOH, food allergies
Term
chronic gastritis
Definition
-pernicious anemia
-Helicobacter Pylori infection
-auto immune disease
Term
peptic ulcer
Definition
a break in the protective mucosal lining exposing submucosal areas to gastric secretions
Term
peptic ulcer
-symptoms
-aggregation
-relief
Definition
--gnawing, burning, cramp like pain

-aggregated by change in position and absence of food in the stomach

-antacids relieve
Term
peptic ulcers - causes
Definition
-bacterial infection, NSAIDS, asprin, stress
Term

peptic ulcer disease

-symptoms

-relief

Definition

-midthoracic back and upper right quadrant pain, including the shoulder

-back pain relieved with antacids

Term
malabsorption syndrome
Definition
a group of disorders characterized by reduced intestinal absorption of dietary components and excessive loss of nutrients in the stool
Term
celiac disease
Definition
-immune-mediated condition
-genetic
--gluten prompts an inflammatory response in the small intestine
Term
malabsorption syndrome syptoms
Definition
Diarrhea
anorexia
Easy bruising – dec vit k
Muscle weakness – dec iron , protein, vit b , folic acid
Bone loss- dec vit d, calcium
Muscle spasm – electrolyte inbalance, dec calcium
Term
inflammatory bowel disease
Definition
IBD
refers to Crohn disease (any part of the bowel) and ulcerative colitis (just the large bowel)

-other symptoms include joint pain, acute arthritis, skin rashes, diarrhea, abdominal pain
Term
irritable bowel syndrome
Definition
-one of the most common GI disorders
-chronically reoccurring abdominal pain or discomfort associated with irregular bowel habits ( frequency , diarrhea , constipation)
-does not necessarily occur with structural, inflammatory, or biochemical abnormality
Term
diverticulitis
Definition
Herniation's of the colon
the mucosa and submucosa herniate through the muscular layers of the colon to form outpouchings containing feces
When food particles or feces become trapped in the diverticula and the pockets become infected and inflamed, then diverticulitis can develop

Symptoms- rectal bleeding,
Term
Appendicitis
Definition
Right lower quadrant pain
nausea/vomit
Fever
Aggravated by incr. abd. pressure
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