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-body's first line of defense -does not differentiate between different types of invaders -non-adaptive |
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system has memory of organisms encountered so as to react more effectively to future invasion |
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identifies foreign substances and tags them |
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types of acquired immunity |
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HUmoral (B) - free floating Cell mediated (T) - in cells |
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treat immune-mediated disorders anti-inflammatory and immunosuppressive |
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immunosuppressive selective suppression of helper T cells |
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cytotoxic to lymphocytes, causes lymphopenia, resulting in immunosuppression |
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moderate - beneficial strenuous - immunosuppression |
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CD4 count is below 200 cells/mL destruction of T helper cells unable to fight off opportunic infection neurologic dysfunction dementia, thin hair & skin, pain |
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widespread tissue pain 90% are women no diagnostic test |
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Fibromyalgia -Pain -Chronic fatigue -headaches -unrefreshed sleep -tenderness -concentration or memory problems |
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Benefits -Pain control -improved QOL -Improved sleep |
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skin stomach acid tears phagocytes NK cells dendritic cells |
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involving B lymphocytes recognizes foreign substance and produces antibodies that bind to it and neutralize it |
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cell-mediated response to bacteria |
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involving T lymphocytes recognizes foreign substances and produces cytokines to help the macrophage lyse and phagocytose |
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cell mediated response to virus |
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Definition
involving cytotoxic T lymphocyte recognizes the cell and destroys it |
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Definition
part of innate immunity recognizes the invading organism and destroys it |
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exercise on neutrophils and macrophages |
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Definition
increases with eccentrics |
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exercise on natural killer cells |
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Definition
number and function increase during exercise, but decline following |
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increase during, fall after |
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depends on severity, so symptoms should be monitored |
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1. flows around body looking for CD4 cells to infect 2. Binds to CD4 and gains entry to the cell 3. infection (viral RNA enters CD4 cell) 4. reverse transcription (copies RNA to look like DNA) 5. integration of new DNA into CD4 nucleus 6. Transcription (CD4 cell is making new HIV) 7. Assembly of the core structure 8. Budding - leaving the cell 9. Breaking free of the CD4 cell |
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