Term
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Definition
| Also Wermer Syndrome. Parathyroid, pancreas, pituitary (PPP). PP pancreatic tumor and prolactinoma in pituitary most common. Mennin protein is poorly understood. Hypoglycemia, Zollinger-Ellison, nephrolithiasis, prolactinemia |
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Term
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Definition
| Sipple Syndrome. Pheochromocytoma, medullary thyroid carcinoma, parathyroid hyperplasia. RET Gain-of-Function mutation (product binds glial-derived neurotrophic factor (GDNF)) |
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Term
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Definition
Loss: aganglionosis, Hirschsprung
Gain: MEN2A |
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Term
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Definition
| Medullary thyroid carcinomas, more aggressive, pheochromocytomas. No hyperparathyroidism. Neuromas, marfanoid habitus. Single substitution in RET causing autophosphorylation |
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Term
| Familial Medullary Thyroid Cancer |
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Definition
| Variant of MEN2A. Mainly medullary thyroid cancer risk but at older age |
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Term
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Definition
| photosensory and neuroendocrine functions |
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Term
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Definition
| Melatonin, circadian rhythm control |
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