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Pathology 23: 1066 - 1073
Robbins and Cotran
11
Pathology
Graduate
03/16/2011

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Cards

Term
Acute Mastitis
Definition
During first month of breastfeeding common. Diffuse spreading infetion. Antibiotic Treatment.
Term
Periductal Mastitis
Definition
Also recurrent subareolar abscess, squamous metaplasia of lactiferous ducts, Zuska disease. Smoking/Vit A deficiency common. Keratinizing squamous metaplasia w/ granulomatous inflammation.
Term
Mammary duct ectasia
Definition
40-50s. Multiparous common. Poorly defined periareolar mass with secretions. Dilation of ducts with granular debris. cholesterol deposits. mimics carcinoma.
Term
Fat Necrosis
Definition
painless palpable mass, history of breast trauma. Giant cells, calcification and hemosiderin set in later.
Term
Lymphocytic Mastopathy
Definition
Also Sclerosing Lymphocytic Lobulitis. Hard lesions with collagenized stroma. DMI common.
Term
Granulomatous Mastitis
Definition
Caused by systemic granulomatous diseases, mycobacteria or fungi. Often immunocompromised. (Lobular: Only in parous women, lactation antibodies)
Term
Fibrocystic changes
Definition
also nonproliferative breast changes. lumpy bumpy, benign. Cystic change: dilation of lobules, turbid, calcifications, alarming when firm. Fibrosis: ruptured cysts with inflammation. Adenosis: increase in acini, enlarged in 'blunt-duct' and possible flat epithelial atypia.
Term
Epithelial Hyperplasia
Definition
Double layer of myoepithelial cells and luminal cells. Irregular distended lumens
Term
Sclerosing Adenosis
Definition
Increased acini per terminal duct. Dilated at periphery.
Term
Complex sclerosing lesion
Definition
sclerosing adenosis, papillomas and epithelial hyperplasia. Radiating projections into the stroma. Also radial scar
Term
Atypic Proliferative Breast Disease
Definition
Often incidental. Resembles carcinoma in situ but lacking features of carcinoma. Ductal: DCIS-like, regularly spaced cells, cribriform spaces, only partially filled ducts. Lubular: LCIS-like, cells do not fill acini, pagetoid spread possible
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