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**Pathology 1287 - 1299
Robbins and Cotran
24
Pathology
Graduate
04/06/2011

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Cards

Term
Diastatic Fracture
Definition
Fracture that crosses a suture
Term
Direct Parenchymal Injury
Definition
Contusion and laceration. Most commonly periorbital frontal lobes and terporal lobes. coup and contrecoup
Term
Contusions
Definition
Broad base deep to the point of impact. edema and hemorrhage. Old lesions are depressed, retracted, yellowish brown
Term
Diffuse Axonal Injury
Definition
Can cause coma, be caused by any motion (rotational). Within hours of injury. Increased microglia
Term
Epidural Hematoma
Definition
Dural arteries are most vulnerable. Luicid interval. Lenticular on CT
Term
Subdural Hematoma
Definition
Between dura and outer arachnoid layer. Bridging veins prone to tearing. Fresh is without extension to sulci.
Term
CNS Ischemia
Definition
Excessive Ca+2, acidosis, red neurons, eosinophilia, pyknosis, karyorrhexis, vacuolization
Term
Penumbra
Definition
Area of at-risk tissue on the periphery of ischemia
Term
Brain Infarct Chronology
Definition
<6 little change. 12 hrs: red neurons, cells disintegrate. 48 hr: pale swollen. 2-10 days: gelatinous and friable. 10-3 wks: liquification
Term
Lacunar Infarcts
Definition
Penetrating Arteries. in the lenticular nucleus
Term
Binswanger Disease
Definition
Large areas of subcortical white matter with hypertensive encephalopathy
Term
Hypertensive Encephalopathy
Definition
atherosclerosis, thrombosis/emolization, arteriolar sclerosis
Term
Intraparenchymal Hemorrhage
Definition
HTN and CAA. 50% putamen. Vessels have basophilic, PAS-positive deposits
Term
CAA
Definition
Cerebral amyloid angiopathy. Amyloid predisposes to intraparenchymal bleeds. restricted to leptomeningeal and cerebral cortical arterioles and capillaries
Term
Ganglionic Hemorrhages
Definition
In the basal ganglia and thalamus
Term
Lobar hemorrhages
Definition
In the lobes of the cerebral hemispheres
Term
Subarachnoid Hemorrhage
Definition
Most commonly saccular aneurysm but also fusiform (atherosclerotic), mycotic, traumatic and dissecting.
Term
Saccular Aneurysms
Definition
2%. Smoking and HTN. Circle of Willis. attenuated media, thickened intima. Adventitia is patent with parent artery
Term
Vascular Malformations
Definition
Afteriovenous malformations, caverous malformations, capillary telangiectasias, venous angiomas
Term
Arteriovenous malformations
Definition
tangled network of wormlike vessels. Shunting and headaches etc.
Term
Cavernous malformations
Definition
greatly distended, loosely organized, thin vessels without intervening nervous tissue. Hemorrhage, infarction, and calcification.
Term
Capillary telangiectasias
Definition
microscopic foci of dilated channels separated by normal brain. Most often pons
Term
Venous angiomas
Definition
carices, ectatic venous channels. Includes Foix-Alajouanine
Term
Foix-Alajouanine Disease
Definition
Also angiodysgenetic necrotizing myelopathy. spinal cord and overlying meninges, often lumbosacral, ischemia myelomalacia. Slowly progressive
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