Term
disorganized mass of normal tissue component
neoplasm?
where is most common location |
|
Definition
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|
Term
benign vs. malignant?
adenoma
papilloma
polyp
cystadenoma
papillary cystadenoma |
|
Definition
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|
Term
teratoma origin?
bone
muscle
bronchial tissue
intestinal
nervous
skin |
|
Definition
mesoderm
mesoderm
endoderm
endoderm
ectoderm
ectoderm |
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Term
|
Definition
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Term
| disordered growth, reversible, premalignant change often in epithelium |
|
Definition
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Term
malignant neoplasm stroma:
abundant fibrous stroma, may be stony hard |
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Definition
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Term
| variation in size, shape, and appearance of cells and nuclei |
|
Definition
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|
Term
malignant neoplasm: stroma:
scant stroma - soft and fleshy |
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Definition
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Term
| what is the central feature in cytodiagnosis of malignancy. |
|
Definition
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|
Term
tumor giant cell
vs.
reactive foreign body giant cell |
|
Definition
large cell with one or more abnormal nuclei by nuclear division w/o cytoplasmic division
have bland nuclei |
|
|
Term
the most reliable feature of malignancy
2nd most reliable feature |
|
Definition
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Term
| contiguous invasive spread of tumor to adjacent structure by direct continuous tumor growth |
|
Definition
| breast ca infiltrating skin |
|
|
Term
| tumor reach peritoneal, pleural spread by direct extension or carry to new location within serous cavity by cavity fluid |
|
Definition
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|
Term
| 2 cancer do not metastasize |
|
Definition
basal cell carcinoma
malignant glial tumor of CNS |
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|
Term
| discontinuous spread of neoplasm to produce secondary tumor growth distant from primary tumor |
|
Definition
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|
Term
most common way for initial spread of carcinoma
|
|
Definition
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|
Term
| why is small lym invade easier than small blood vessel |
|
Definition
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|
Term
| what is area of lymph node first involved by metastatic tumor |
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Definition
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|
Term
| supraclavicular lymph node with metastasis from abdominal malignancy |
|
Definition
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|
Term
hematogenous metastasis
spread by what type of tumor |
|
Definition
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|
Term
| whats the 2 most frequent hematogenous metastasis |
|
Definition
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|
Term
what is severe weight loss and loss of lean body mass, anemia and weakness in late stage of malignant neoplasm
what factor
is it from nutritional demands of tumor |
|
Definition
cancer cachexia
TNF-alpha
not from nutritional demand of tumor. |
|
|
Term
hormonal secretion:
acromegaly
cushing's syndrome
hypertension
hypercalcemia |
|
Definition
pituitary tumor
adrenal cortical tumor
adrenal medulla tumor
parathyroid neoplasm |
|
|
Term
| most common paraneoplastic syndrome |
|
Definition
|
|
Term
| some paraneoplastic syndrome |
|
Definition
endocrinopathy
acanthosis nigrican
trousseau's sign
hypertrophic osteoarthropathy
hypercalcemia
neuromyopathy
polycythemia |
|
|
Term
endocrinopathy of paraneoplastic syndrome
ACTH
insulin-like substance |
|
Definition
small cell undifferentiated carcinoma of lung
mesothelioma, fibrosarcoma |
|
|
Term
| 90% of what cancer has acanthosis nigrican |
|
Definition
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|
Term
| Trousseau's sign/migratory venous thrombosis, usually in 3 ca. |
|
Definition
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|
Term
paraneoplastic syndrome
hypertrophic osteoarthropathy |
|
Definition
|
|
Term
paraneoplastic syndrome
hypercalcemia via 2 ways.
2 cancer for each of the 2 ways |
|
Definition
bone resorption:
breast cancer
MM
parathormone-like peptide
squamous cell ca. of lung
head and neck |
|
|
Term
paraneoplastic syndrome:
neuromyopathy |
|
Definition
|
|
Term
paraneoplastic syndrome:
polycythemia, 3 causes |
|
Definition
renal cell carcinoma
hepatocellular
angiocarcinoma |
|
|
Term
| what is most common ca increased in immunodeficient host |
|
Definition
|
|
Term
| spontaneous regression ca. |
|
Definition
|
|
Term
immunohistochemistry for tumor:
what do u use for
leukocyte
neuronal tumor
muscle tumor
mesenchymal tumor
epithelial tumor |
|
Definition
CD45
neurofilament protein
desmin
vimentin
cytokeratin
VS - vimentin for sarcoma
CC - cytokeratin for carcinoma |
|
|
Term
tumor marker
hcG
AcTH
parathyroid like hormone
calcitonin
CEA
AFP
PSA
IgG kappa |
|
Definition
choriocarcinoma, teratocarcinoma
small cell carcinoma of lung
squamous cell carcinoma of lung
thyroid medullary carcinoma
colon ca.
hepatocarcinoma
prostate ca.
MM |
|
|
Term
| most important prognostic indicator of tumor |
|
Definition
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|
Term
| what 3 caner is in young people with no age extremes |
|
Definition
osteosarcoma
testicular tumor
hodgkin's disease |
|
|
Term
type of genetic tumor
xeroderma pigmentosum
ataxia telangiectasia
bloom's syndrome
fanconi's anemia
familial retinoblastoma
FAP
MEN
neurofibromatosis
breast-ovarian |
|
Definition
AR
AR
AR
AR
AD
AD
AD
AD
familial |
|
|
Term
carcinogen
polycyclic hydrocarbon |
|
Definition
lung
mouth
esophagus
pancreas
urinary bladder
cervix |
|
|
Term
|
Definition
| transitional cell ca. of bladder |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
carcinogen
vinyl chloride |
|
Definition
|
|
Term
|
Definition
|
|
Term
carcinogen
alkylating agent |
|
Definition
|
|
Term
carcinogen
cyclophosphamide |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| cervical squamous cell ca. |
|
|
Term
|
Definition
Burkitt lymphoma
nasopharyngeal ca. |
|
|
Term
|
Definition
|
|
Term
|
Definition
Kaposi's sarcoma
high grade B lymphoma |
|
|
Term
carcinogen
ultraviolet radiation |
|
Definition
|
|
Term
carcinogen
ionizing radiation |
|
Definition
|
|
Term
leukemia caused by 3
carcinogen
|
|
Definition
alkylating agent
ionizing radiation
benzene |
|
|
Term
| 2 extracellular matrix are on BM as condensed sheetlike structures that separate epi and endo from interstitial CT |
|
Definition
|
|
Term
| 2 ECM on interstitial extracellular matrix |
|
Definition
Type 1 collagen
fibronectin |
|
|
Term
| 3 mechanism of degrade of ECM by tumor |
|
Definition
Type 4 collagenase by metalloproteinase
plasminogen activator converting plasmin to break laminin + secrete type 4 collagenase
degradation of type 1+3 by another collagenase |
|
|
Term
homing to specific organs
prostate:
lung: |
|
Definition
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