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PATHO
QUIZES
75
Pathology
Graduate
11/29/2011

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Cards

Term
Incidence
Definition
Number of disease present in population (1/10,000)
Term
Symptoms
Definition
Subjective comments made by the patient
Term
Signs
Definition
Objective: measurable. Ex color change, BP , HR, RR
Term
Etiology
Definition
What causes the disease ( usually do not know)
Term
Pathogenesis
Definition
How the disease manifests itself (usually know this)
Term
Evaluation
Definition
What the disease is (not examination
Term
Diagnosis
Definition
Medical Pathology
Term
Pathophysiology
Definition
The study of functional or physiologic changes in the body that result from the disease process
Term
Disease
Definition
Any deviation from the normal state of health or wellness.
Term
Disease
Definition
When homeostasis can't be maintained w/o intervention.
Term
Prognosis
Definition
What is the likelihood for the Pt to handle the disease.
Term
Treatment (intervention)
Definition
Varies with prognosis. What we do to intervene with the Pt.
Term
Examination
Definition
Physical observation of the Pt.
Term
Pathopneumonic
Definition
The one thing about the disease that identifies that disease. Hallmark of a disease.
Term
Hereditary
Definition
Genetic transmission
Term
Environmental
Definition
EX: Air pollution, asbestos
Term
Intrinsic (endogenous)
Definition
Something that you produce, ALLERGIES
Term
Idiopathic
Definition
They don't know the cause of the disease process.
Term
Iatrogenic
Definition
Physician induced process. Wrong medications, chemotherapy.
Term
Hypoxia
Definition
Lack of O2. Stops aerobic respiration.
Term
Ischemia
Definition
Lack of blood/perfusion. CO poison--> hypoxia prior to Ischemia.
Term
Physical agents
Definition
Leads to cellular death. Burns, extreme cold
Term
CHemicals
Definition
excess of causes death
Term
Biological agents
Definition
Bacteria, virus
Term
Immune mechanisms
Definition
Antibodies attacking antibodies or self attacks self
Term
Genetic derangements
Definition
Sickle cell anemia
Term
Nutritional imbalances
Definition
Obesity-- 55% of population
Term
Reversible Cell Injury
Definition
Cellular swelling =Hydropic swelling---cells taking on Na due to poor Na/K+ pump.
-Wherever salt goes
Term
Endoplasmic reticulum
Definition
makes proteins, release ribosomes
Term
Fatty Change
Definition
Liver cells accumulate fat when damaged
Term
Plasma Membrane
Definition
Blebs
-If PM is damage, the membrane bulges out
Term
Removal of Stressor
Definition
Cell returns to normal when stressor is absent
Term
Persistence of Stressor
Definition
Adaptation, continual alcohol intake for years.
Term
Induction of ER
Definition
ETOHic---grows more of this to detoxify the alcohol
Term
Sequestration of focal injury
Definition
Body walls off the injured area to keep away from the rest of the body
Term
Atrophy
Definition
Decrease in the SIZE of the cell. Ex: hormone reduction w/ aging results in breast size reduction
Term
Hypertrophy
Definition
Enlarging of the cell. L ventricular hypertrophy. Not an increase in the number of the cells
Term
Hypoplasia
Definition
Decrease in the number of cells
Term
Hyperplasia
Definition
Increased number of cells. Ex: callus
Term
Metaplasia
Definition
Change from one cell type to another type. Ex: Smoking-> trachea turns into stratified squamous instead of pseudo stratified.
Term
Dysplasia
Definition
Cell looks and acts ABNORMAL, but not CA... yet
Term
Aplasia
Definition
Lack of growth, did NOT form the organ or tissue such as someone that is born with out vertebrae---spina bifid a
Term
Neoplasia
Definition
Independent growth of cells. Forms tumor.
Term
Permanent Cells
Definition
CNS, PNS, cariomyocytes. So post CVA or MI, do not regrow neurons or muscle cells respectively.
Term
Stable Cells
Definition
Skeletal muscle, kidney, lung, liver.
Term
Labile Cells
Definition
Constantly turned over. Examples: skin, lining of GI Tract, blood.
Term
Mitochondria
Definition
swell and form large deposits inside of them with protein or Ca+ inside them. The powerhouse stops working--aerobic respiration stops.
Term
Plasma membrane
Definition
Blebs are sublethal. If dead, then becomes permeable to everything.
Term
Endoplasmic reticulum
Definition
break away.
Term
Lysosomes --> (NECROSIS)
Definition
Membrane breaks down and digestive enzymes release w in the cell.
Term
Nucleus- Pyknosis
Definition
clumped onto itself
Term
Nucleus- Karyorrhexis
Definition
nucleus fragments into pieces.
Term
Karyolysis
Definition
nucleus disolves
Term
Necrosis
Definition
Process of removal of dead tissue. Lysosomes start the process and macrophages finish.
Term
Coagulative Necrosis
Definition
Usually found following ischemia, loss of normal organelle structure, Ischemia or infarction,
Term
Liquefactive necrosis
Definition
Accumulation of PMN's (pus), usually found with bacterial infection.
Term
Fat necrosis
Definition
Usually found with pancreatic disease that leaks lipases. Ex: acute pancreatitis or abdominal trauma.
Term
Caseous Necrosis
Definition
(cheese) mostly found with TB; due to resemblances of cottage cheese. CXR---Ca+ deposits that is what is left after damage. Once TB, always TB
Term
Fibrinoid Necrosis
Definition
that is found in the walls of blood vessels with insulation of plasma proteins. Fibrin leaks into the interstitial area.
Term
Gangrenous Necrosis
Definition
Caused by infection of ischemic tissue by clostridial perfringens (anaerobic microorganism). This infective agent contains many spreading factors-- myotoxin, hemolysins, & phospholipases-- that rapidly can lead to amputation or death. Hemoglobin turns black= eschar.
Term
Health
Definition
viewed as a continuum. Wellness on one end and illness on the other end.
Term
Health
Definition
Dynamic process that varies with changes in interactions between an individual and the internal & external environments.
Term
Acute Illness
Definition
has a relatively rapid onset & short duration
Term
Subacute illness
Definition
describes a time course that is between acute & chronic
Term
Chronic Illness
Definition
results permanent impairment or disability or need for special rehabilitation and or long term medical management
Term
Primary prevention
Definition
removing or reducing the disease risk factors
Term
Secondary prevention
Definition
promote early detection of disease & employ preventive measures to avoid further complications.
Term
Tertiary prevention
Definition
aimed at limiting the impact of the established disease. Involves rehab and may end when no further healing is expected.
Term
65% of all deaths
Definition
cardiovascular dz, CA, DM
Term
Lipofuscin
Definition
an aging pigment lipid granule, found especially in neurons & cardiac myocyte, is suspected to cause pressure on the cell nucleus and interfere with cellular function
Term
NCV
Definition
Nerve Conduction velocity
Term
GFR
Definition
Glomerular Filtration Rate
Term
Wear and tear theory
Definition
Cells that can't regenerate such as cardiomyocytes become worn out.
Term
Free radical theory
Definition
the chemical nature & wide presence of free radicals causing DNA damage & cellular oxidative stress with aging.
Term
Telomere aging clock theory
Definition
end of the chromosomes that acts as a clock signaling the onset of cell senescence (telomere may be used as CA marker)
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