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Study of the cause of disease |
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Reversible changes in the number,size, phenotype, metabolic activity, or functions of cell in response to environment. Can be pathologic or physiologic |
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Replacement of one type of adult cell to another type of adult cell in response to a stressor |
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abnormal growth or development |
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interruption of blood supply |
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injury caused by reperfusion to ischemic area |
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occurswhen excess ROS accumulates, can lead to cell injury |
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Found in mitochondria, initiates apoptosis |
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Component cells are dead, basic tissue architecture lasts for several days, tissue has firm texture, characteristic of infacts in solid organs (not brain) |
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From focal bacteria or fungal infections, dead cells liquified, initiated by acute inflammation |
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From foci tuberculous infection, dead tissue contains framented and lysed cells, no architeture remains, usually enclosed by inflammatory border |
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focal areas of fat destruction, from release of pancreatic liases of acute pancreatitis, breakdown of fatty cells, Fatty acids combine with Ca+ to produce chalky white areas |
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cell death due to loss of blood supply, undergoes coagulative necrosis in multiple layers, when bacterial superimposed leads to liquidification and causes wet gangrene |
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occurs in necrosis of any kind, initially starts in mitochondria of dying cells, ca+ precipitates form, based on concentrations of Ca+ and PO4 |
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Can occur in normal tissues that are hypercalcemic, Ca+ precipitates form, Main cause is increased PTH, destruction of bone, vitamin D disorders or renal failure |
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