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Patho
ISU PA
15
Biology
Graduate
09/12/2010

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Term
Etiology
Definition
Study of the cause of disease
Term
adaptation
Definition
Reversible changes in the number,size, phenotype, metabolic activity, or functions of cell in response to environment. Can be pathologic or physiologic
Term
Metaplasia
Definition
Replacement of one type of adult cell to another type of adult cell in response to a stressor
Term
dysplasia
Definition
abnormal growth or development
Term
ischemia
Definition
interruption of blood supply
Term
Reperfusion injury
Definition
injury caused by reperfusion to ischemic area
Term
Oxidative stress
Definition
occurswhen excess ROS accumulates, can lead to cell injury
Term
cytochrome C
Definition
Found in mitochondria, initiates apoptosis
Term
Coagulative Necrosis
Definition
Component cells are dead, basic tissue architecture lasts for several days, tissue has firm texture, characteristic of infacts in solid organs (not brain)
Term
Liquefactive Necrosis
Definition
From focal bacteria or fungal infections, dead cells liquified, initiated by acute inflammation
Term
Caseous Necrosis
Definition
From foci tuberculous infection, dead tissue contains framented and lysed cells, no architeture remains, usually enclosed by inflammatory border
Term
fat necrosis
Definition
focal areas of fat destruction, from release of pancreatic liases of acute pancreatitis, breakdown of fatty cells, Fatty acids combine with Ca+ to produce chalky white areas
Term
Gangrenous necrosis
Definition
cell death due to loss of blood supply, undergoes coagulative necrosis in multiple layers, when bacterial superimposed leads to liquidification and causes wet gangrene
Term
Dystrophic calcification
Definition
occurs in necrosis of any kind, initially starts in mitochondria of dying cells, ca+ precipitates form, based on concentrations of Ca+ and PO4
Term
Metastatic Calcification
Definition
Can occur in normal tissues that are hypercalcemic, Ca+ precipitates form, Main cause is increased PTH, destruction of bone, vitamin D disorders or renal failure
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