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patho-final review
patho final
141
Nursing
Undergraduate 1
05/03/2013

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Cards

Term
what is the cytoskeleton function?
Definition
structure & movement
Term
what are ribosomes?
Definition
site of protein
Term
what does diffusion do?
Definition
wants to be even/uniform
Term
facilitated diffusion of a nonlipid soluble through a membrane needs a?
Definition
carrier protein
Term
countertransport the 2nd active transport?
Definition
move the opposite way
Term
increased level of messengers would indicate what receptors?
Definition
down regulation.. so few receptors
Term
what activates the 2nd messeneger?
Definition
g protein linked receptor
Term
ligand/protein open what channels?
Definition
ligand gated channels
Term
what is anaerobic metabloism?
Definition

small amt of ATP

pyrvic acid biproduct

Term
what happens when threshold potential is met?
Definition

acttion pot. will happen not stopping at this point

K+ out of cell/Na in cell.. cell positive

depolarization responds by contractin

Term
what is cyclin?
Definition
checkpoint in cell division
Term
what does gene P53 do?
Definition
repair DNA
Term
what is a characteristic of a malignant tumor?
Definition
poorly differentated cell
Term
characteristic of cancer cell
Definition
undiffereinatated cell ( don't differientate)
Term
toxicities attack the GI tract why?
Definition
b/c rapid dividing cellls
Term
how is anaphylactic different from any other type 1 hypersensitivity?
Definition
its lifethreatening
Term
mast cell regradation release histamines that cause?
Definition

vasoconstriction, bronchoconstrictions,

SOB, decrease BP

Term
what is the MHC?
Definition
self identifier
Term
what is a type II hypersensitivity?
Definition
antibody/antigen complex
Term
systemic lupus errythema (SLE) is a type III hypersens. what do you expect to find?
Definition
deposit in tissue and damage tissue
Term
what cells do HIV affect?
Definition
CD4
Term
when can HIV be spread? AT what time?
Definition
Term
when managing AIDs what do you want to look at at?
Definition
viral load and CD4 count
Term
neutrophils `are 1st responders they relsease proteases prolytic enzymes what do they do?
Definition
breakdown proteins
Term
what do macrophage do?
Definition
APC (antigen presenting complex) holds out so other recognizes it or phagoctyes engulfs invader
Term
what is the last step of the complement system?
Definition
membrane attack complex
Term
mast cell that start inflamm. process?
Definition
leukotrienes
Term
uncapsulated part of the lymph system where cells go to mature?
Definition
peyers patches
Term
what is the CD4 cells ?
Definition
helper t cell
Term
what is the CD8 cell?
Definition
cyctoxic t cell
Term
what do the plasma B cells do?
Definition
send antibody to attack the antigen
Term
antibody hoooks up with the antigen where at?
Definition
epitopes
Term
the primary immune response (cd4) happens when?
Definition
2-3 weeks after exposed
Term
MRNA is porcessed when?
Definition

take out introns

take out part of exons

Term
with TRNA the amino acid matches with the anitcodon of?
Definition
MRNA
Term
At the end of meoisis 1 copy of chromosomes witch ends why?
Definition
so we have unique gametes
Term
what is genetically composed material called?
Definition
genotpyes
Term
both parents have homozygotes alleles.. what is the chance the child will have the allele?
Definition
all or none???
Term
what do stressed cells want to do?
Definition
maintain normal function
Term
what are free radical cells?
Definition
unstable
Term
when you have a hypoxic cell injury whta happens?
Definition
Term
what are the adnvantages of apotosisis over necrotic tissue?
Definition

natural process

no inflammatory process

Term
when there is cell membrane damage what does this do to the cell?
Definition
causes the cell to shrink
Term
what is the general adaption system?
Definition
action of hormones in stressful times
Term
cortisol is the stress hormone what does it do?
Definition
alters fat, glucose and protein metabolism
Term
what does ADH do?
Definition
vasoconstictor and decreased urine output
Term
nor/epiniphrenine does what?
Definition
increased BP, HR and decreased urine output
Term
angiotensin II does?
Definition
vasoconstricts
Term
aldosterone does?
Definition
increased blood volume and BP and decreased urine output
Term
whta happens during the vascukar stage of acute inflamation?
Definition

intial vasoconstriction follwed by vasodilation

capillaries more permable and inflamm. mediatiors released

Term
what does and increased number of bands indicate?
Definition
not enough WBCS manufactured
Term
you have a pt with a fever what causes the tempertaure increase?
Definition
pyrogens give false set point and go to hypothalamus
Term
You are taking care if a ICU patient with a gunshot wound to the chest. He  has a fever for longer then 24 hours, but then returns to normal what do you call this?
Definition
remiitment
Term
If you have a patient with SIRS what can you expect to see? ( when inflam goes systemic)
Definition
vasodilation, increased vascular permability, and maldisbrition of fluids
Term
what is disturbtive shock?
Definition
poor perfusion of fluid
Term
what is cold shock described as ?
Definition
decreased oxygen
Term
you have a pt with a abdomen wound.. what do you want to see?
Definition
fibrinogen tissue
Term
what is the difference btw lyphoma and leuekemia?
Definition
leukemia in in the bone
Term
difference btw hogdkins and non hogdkins
Definition
hodgkins invade with reed sternburg cells
Term
mononuclueosis infects a person with EBV virus what does this effect?
Definition
b cells
Term
patient with AML is experiencing bruising easily and epistaxis what causes these s/s?
Definition
decreased platelet count
Term
a patient with multiple mylema is experiencing renal failure why?
Definition
bence jones proetin are being excreted in urine..damage
Term
what makes a bood clot?
Definition
fibrin
Term
when clot retracts what causes it to breakdown?
Definition
plasmin
Term
what is the diff. btw the platelet disorder ITP & TTP?
Definition
ITP is the destruction of platelets
Term
What is the treatment for a genetic bleeding disorder?
Definition
replacement of factor via IV
Term
where is the most of the fluid found?
Definition
intracellular space
Term
what would a hypotonic solution cause a cell to do?
Definition
swell
Term
pressure that keeps the fluid inside of capillaries?
Definition
colloid osmotic pressure
Term
hypothalamus maintains h2o balance what does it look at?
Definition
blood volume and serum osmolarity
Term
whta causes the lack of thirt?
Definition
low osmolarity
Term
Your patient has an increased Na+ level, and is dehydrated what type of solution would you give?
Definition
isotonic
Term
why does hyperkalemia cause heart dysrrthmias?
Definition
it rasies the RMP to threshold allowing to fire more easily
Term
what does parathyroid hormone cause?
Definition
increased Ca+ = hypercalemia
Term
what causes your muscle to spasm?
Definition
hypocalcemia- it makes nerves fire more easily
Term
what does manesium do?
Definition
it causes dysrrthmias of the heart ( life threatening dysrrthmias)
Term
If you dont have a normal ph it will affect?
Definition
metabolic activity
Term
when can compensation occur?
Definition

when PH returns to normal

she gave examples... always pick the ph in normal range EX) pH=7.37

Term

intrepret this blood gas?

ph: 7.34

CO2: 60

HCO3: 20

 

Definition
respiratory acidosisis
Term

intrepret blood gas?

ph: 7.52

CO2: 54

HCO3: 27

Definition
metabolic alkalosis
Term
a patient is experiencing fear and anxiety what do you expect their blood gas to be?
Definition

resp. alkalosis ( increased pH, and HCo3, decreased CO2)

( prolly going to be hyperventilating)

Term
what does surfactant do?
Definition
it perevents the alveloar collapse at exhalation
Term
what is true about dead space?
Definition
physiological dead space is abnormal and anatomic dead space is normal
Term
if ventilation is greater than perfusion what can you expect to see?
Definition
mucus secretions
Term
A pt with pulmonary edema how would there diffusion be affected?
Definition
d/t edema it will be affected with available surface area and membrane thickness
Term
oxyhemoglobin dissociation curve has an acidotic L shift what happens to the affinity?
Definition
decreased affinity
Term
if the oxyhemoglobin has an R shift with decreased CO2, temperature and a elevated PH what does this do/
Definition
high affinity- Hgb binds easily to O2
Term
what does carbonic anahrydrase do?
Definition
allows CO2 to remain the buffer
Term
central chemoreceptors are stimulated by?
Definition
PH change (acidotic)
Term
A person is infected with TB the macrophage and cell mediated response causes what?
Definition
Ghon focus formation
Term
diff. btw flu and pneumonia ?
Definition
malaise profound onset
Term
ARDS is characterized as?
Definition
hypoxia that does not respond to increased O2 levels
Term
ARDSis caused by what?
Definition
pulmonary capillary injury
Term
2nd pulmonary edema is due to what?
Definition
increased pulm. blood flow, hypoxemia, and pulm. vascular obstruction
Term
main cause for axelactisis
Definition
obstructed airway
Term
what is known as the permanent dilation of bronchi?
Definition
bronchietasis
Term
pulm. embloism mainly comes from where?
Definition
DVT
Term
What is Cor pulmonale?
Definition
heart failure  from resp. failure
Term
what is a characteristic of emphysema?
Definition
barrel chest
Term
what is emphysema ?
Definition
increased air space and destruction/loss of alveoli tissue
Term
what is chronic bronchitis and what can you expect to see?
Definition
due to chronic infections and hypersecretions noted
Term
what is pleural effusion?
Definition
fluid in cavity
Term
tension pneomothorax will cause the tacheal shift why?
Definition

pressure change

positive pressure in pleural space causes this

Term
what causes kidneys to secrete erythopeotein?
Definition
tissue hypoxia starts the process
Term
diff. btw retic and mature RBCs?
Definition
retic have endoplasmic reticulum and other organelles still but can't carry O2.. mature carry O2
Term
what causes buildup of uncongulated bilirubin?
Definition
increased production of RBCs
Term
what is megablastic anemia?
Definition
defiency in vit. B12 and folic acid
Term
what is sickle cell caused by?
Definition
decreased O2 in hemoglobin- beta linked together and sickle
Term
Vessels that takes blood from R venticle to lungs
Definition
pulm. artery
Term
when sacromeree have good even contraction in syntinum what helps act. pot?
Definition
incalated disc at gap junction
Term
what electrolytes is responsible for heart muscle contraction?
Definition
ca+
Term
when do coronary arteries perfuse?
Definition
diastole
Term
Man comes into ER with blood loss (severe) what three meanings of life does this mess up?
Definition
preload
Term
when looking at EGD what do you look at?
Definition
look at speed and direction
Term
what are foam cells considered?
Definition
machophage that engulf too much LDL
Term
what makes plaque more vulnerable easy to rupture ?
Definition
inflammation
Term
what are s/s occlusion to peripheral extremities/artery?
Definition
pain and pale extremities
Term
anuerysm cause wall of artery to weaken and stretch this increases the risk for ?
Definition
rupture and hemorrhage
Term
a person with  DVT.. if it breaks off look for?
Definition
Pulm. embolism
Term
the barorecptors in the carotid/aortic arch are stimualted by?
Definition
change in pressure
Term
what happens when barorecptors and and SNS are stimulated?
Definition
vasoconstrict and increased heart rate
Term
what does aldosterone do?
Definition
reasbsorp H20 and Na+ and increase BP and volume
Term
ANP is used to lower BP.. how does it do this?
Definition
increased Na+/H2O excretion and vasodilation
Term
pt have a BP of 150/90 what stage of HTN is this?
Definition
type 1/stage 1
Term
pericardial effusion will lead to what?
Definition
cardiac tamponade
Term
Unstable angina turns into...
Definition
acute coronary syndrome
Term
A person with ACS (acute coronary sydrome) whta do you see on their EGD?
Definition
elevated ST wave ( Q wave abnormal)
Term
what is the very best way to check for an MI?
Definition
tropinin (cardiac marker)
Term
diff. btw transmural and subendocardial MI?
Definition
transmural entire muscle thickness (worse of two)
Term
what is a PCI intervention?
Definition
PTCA
Term
cardiac remodeling leads to what?
Definition
decreased cardiac output
Term
what are s/s of left sided heart failure?
Definition
dyspnea
Term
a stenotic valve can't do what?
Definition
can't open... oens poorly
Term
cardogenic shock starts with
Definition
decreased cardiac output
Term
what does the intra aorotic balloon pump do?
Definition
takes over work of heart.. decreases work of heart
Term
what is the vasta recta?
Definition
netwrok of blood vessels. capilarry bed how absorption and secretion take place
Term
which stage of urine formation acts as acid/base buffer/
Definition
reabsorption
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