Term
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Definition
| processes in the body to prevent blood loss |
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Term
| effects of hemostatic dysfunction |
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Definition
effecting the delivery aspect of blood: injury/ischemia/infarction
effecting hemostasis directly: hypovolemia/shock
effecting the immune function of blood: infection |
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Term
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Definition
| Hct: the erythrocyte composition of blood |
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Term
| cellular components of blood |
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Definition
erythrocytes
leukocytes (baso/neutro/eosinophils, monocytes, and B & T cells)
Platelets/Thrombocytes |
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Term
| plasma components of blood |
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Definition
water
Proteins: albumin, globulins (IgG, etc.), clotting factors (fibrin, etc.), and lipoproteins (HDL etc.) |
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Term
| physical/temporal characteristics of RBCs |
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Definition
pliable, biconcave disc
120 day life span |
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Term
| The process of erythropoiesis (intermediates and locations) |
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Definition
| [marrow] proerythroblast (no Hb)--> erythroblast-[blood]-> reticulocyte--> erythrocyte |
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Term
| 4 factors necessary for the synthesis of erythrocytes |
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Definition
erythropoietin: cytokine
Fe: Hb
B12 & Folic Acid: DNA synthesis |
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Term
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Definition
| neutro/eosino/basophils, battle infection; neutrophils make up ~1/2 of WBC |
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Term
|
Definition
B cells and T cells, immune response
make up ~1/3 of white blood cells |
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Term
|
Definition
phagocytic, become macrophages in tissue
make up <1/10 of WBC |
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Term
| 5 major blood stem cell lineages |
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Definition
lymphoid (B/T/Plasma)
monocyte colony forming unit (CFU)
granulocyte CFU
megakaryocyte CFU (platelets)
erythrocyte CFU |
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Term
|
Definition
M: 4.32-5.72 trillion cells/L
F: 3.9-5.03 trill/L
OR: ~4.74 trill/L, and M>F |
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Term
|
Definition
M: 135-175 g/L
F: 120-155 g/L
OR: ~146, and M>F |
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Term
|
Definition
M: 38.8-50%
F: 34.9-44.5%
OR: ~42.1%, and M>F |
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Term
|
Definition
3.5-10.5 bill/L
OR: ~7 bill/L |
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Term
|
Definition
150-450 bill/L
or: ~300 bill/L |
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Term
| What the Differential count measures |
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Definition
| %ages of each type of leukocyte |
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Term
| what the erythrocyte sedimentation rate is for |
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Definition
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Term
|
Definition
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Term
| cellular and plasma components responsible for control of bleeding |
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Definition
cellular: platelets/thrombocytes
plasma: fibrinogen/fibrin |
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Term
| component of blood which carries cells |
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Definition
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Term
|
Definition
Vice President Fitzgerald Commands Clout:
Vasoconstriction
Platelet plugs
Fibrin clot
Clot retraction
Clot dissolution |
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Term
| purpose of vasoconstriction in clotting |
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Definition
| reduce blood flow to injured tissue, reduce blood loss |
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Term
| physiology of platelet plug formation |
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Definition
| Thromboxane A & ADP attract platelets to injury, they adhere to the damaged walls, and aggregate until plug is formed |
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Term
| physiology of coagulation |
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Definition
| the intrinsic and extrinsic pathways each produce Factor Xa ("Ten-A" not "X-A") which converts prothrombin--> thrombin which converts fibrinogen--> fibrin--> stabilizes clot |
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Term
| Intrinsic vs. extrinsic system pathway examples |
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Definition
intrinsic: within the vessel, i.e. plaque rupture
extrinsic: any kind of trauma, injury to the outside |
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Term
| physiology of clot retraction |
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Definition
| thrombocytes are reintegrated into the bloodstream via vasospasm, and remaining fibrin closes the wound |
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Term
| physiology of clot dissolution |
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Definition
| plasminogen--> plasmin--> breaks up clot |
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Term
|
Definition
Prothrombin time: high in cases of anticoagulate therapy (warfarin/Coumadin)
partial thromboplastin time: elevated during heparin therapy |
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|
Term
| elevated fibrin degredation products... |
|
Definition
| ...indicates a dissolving clot somewhere in the system |
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