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Patho Exam 3 Blasts from the Past & General Comments
Material on Exam 3 learned before Exam 2 and General Material from after Exam 2
23
Pathology
Graduate
11/13/2013

Additional Pathology Flashcards

 


 

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Term
renin-angiotensin-aldosterone system
Definition
low blood pressure--> baroreceptors--> JG cells--> Renin--> angiotensinogen (from the liver)--> angiotensin I--> lungs: ACE--> angiotensin II--> vasoconstriction + adrenal cortex: aldosterone--> Na+ retention--> Water retention--> increased vascular volume--> increased blood pressure
Term
determinants of cardiac output
Definition
preload: volume of blood in left ventricle before systole (End Diastolic Volume)
afterload: pressure req'd to pump out preload
contractility: ability of the heart to change its force of contraction without changing its resting length (as is necessary with skeletal muscles)
heart rate:
Term
normal cardiac circulation through heart, arterial and venous system
Definition
right atrium--> tricuspid--> right ventricle--> pulmonic valve--> pulmonary artery--> lungs--> pulmonary veins--> left atrium--> bicuspid/mitral valve--> left ventricle--> aortic valve--> aorta--> arteries--> arterioles--> capillaries--> venules--> veins--> superior/inferior vena cava
Term
serum cardiac markers
Definition
troponins (TnT and TnI) as well as creatine kinase (CK) are both markers which in high concentrations are indicative of MI.
Term
different types of tests that can be done to evaluate coronary blood flow and myocardial perfusion
Definition
EKG: shows signs of ischemia
cardiac cath: gold standard: inject dye via major artery and visualize flow
echocardiogram: ultrasound
stress testing: exercise, increase HR
nuclear imaging: perfusion imaging, infarct imaging
Term
normal cholesterol, LDL, HDL, triglyceride levels
Definition
Cholesterol: <200 mg/dL
LDL: <100
HDL: 40-60
Term
systole
Definition
ventricular contraction, expulsion of blood from heart into circulation
Term
diastole
Definition
ventricular relaxation, filling of chambers with blood
Term
pulse pressure
mean arterial pressure
Definition
PP: systolic pressure - diastolic pressure
MAP: average pressure in arterial system during ventricular contraction & relaxation
Term
repolarization, depolarization, relative refractory period, absolute refractory period
Definition
R: after membrane potential has reached threshold, and the AP has fired, the potential returns to resting state
D: the dropping of the membrane potential below resting state in reaction to the firing of the action potential
RRP: membrane potential is high enough to be acted on, but not quite at resting yet
ARP: the membrane potential is below the minimum required for it to be acted on
Term
claudication
Definition
severe muscle pain caused by arterial occlusion r/t PAD
Term
angina
Definition
pain caused by ischemia
Term
pulmonary edema
Definition
fluid accumulation in the air spaces and parenchyma of the lungs
Term
coronary artery circulation.
Definition
during systole, blood is pumped outward through the aortic valve, upon diastole, the blood remaining in the aorta is channeled through the LMCA, LADA, CB, RCA, & PDA to the cardiac tissue
Term
classification of BP for adults
Definition
Normal: <120/80
PreHTN: 120/80-139/89
HTN1: 140/90-159/99
HTN2: >160/100
Term
normal conduction through the heart (and inherent firing rates of pacemakers)
Definition
SA node (60-100 bpm)--> AV node (40-60)--> bundle of his--> purkinje--> ventricles (20-40)
Term
area of the heart supplied by left anterior descending coronary artery
Definition
LMCA: Left Side of Heart
LADA: Inferior Left Ventricle
Term
area of the heart supplied by circumflex branch
Definition
CB: Anterior Left Ventricle
Term
area of the heart supplied by right coronary artery
Definition
RCA: Right side of heart
PDA: Right ventricle
Term
pair the waveforms with the electrical stages of the heart: PQRSTUV
Definition
P: atrial depolarization
PQ: AV delay
PR interval: .12-.20 sec, prolonged: heart block
QRS: ventricular depolarization; duration: .10-.12 sec, prolonged: abnormal ventricular polarization (VTAC, bundle branch block)
T: Ventricular repolarization, directly related to K concentration
U: repolarization of Purkinje's
V: trick question
Term
clinical manifestations of right and left sided heart failure
Definition
Right: tissue issues: edema, ascites, hepatomegaly, etc.
Left: pulmonary problems: tachypnea, rales, pulmonary edema, cyanosis
Term
normal CO
Definition
3.5-8 (6)
Term
electrolyte which influences cardiac contractility the most
Definition
Ca++
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