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Patho Exam 2 DM
Johns Diabetes Lecture
13
Pathology
Graduate
10/23/2013

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Term
energy sources for human body and energy produced by each in kcal/g
Definition
carbohydrates--> CO2 & H2O: 4kcal/g; stored as glycogen in muscles/liver
protein--> amino acids: 4kcal/g; stored as polypeptides (full proteins) in muscle
fat--> fatty acids and trigs: 9kcal/g; stored as triglycerides in liver and adipose tissue
Term
The effects of the following on Glucose:
Insulin
Glucagon
Epinephrine
GH
Cortisol
Definition
I: glucose out of blood into cells, anabolizes glycogen, inhibits gluconeogenesis
GCG: catabolizes glycogen, promotes gluconeogenesis
E: breaks down glycogen, keeps blood glucose up during stress
GH: increases protein synthesis, mobilizes adipose triglycerides, antagonizes insulin
C: stimulates gluconeogenesis in liver, essential for starvation survival
Term
Type Ia DM
Definition
immune-mediated destruction of beta-cells--> decreased insulin production
Term
Type Ib DM
Definition
non-immune-mediated destruction of beta-cells--> decreased insulin production

strong familial correlation, no evidence of genetic inheritance
Term
Type II DM
Definition
obesity/genetic predisposition--> overproduction of insulin--> beta cell destruction and/or receptor desensitization--> hyperglycemia--> DM II
Term
Metabolic Syndrome
Definition
hi trigs: >150 low HDL: <50
hi bmi: >25 hi waist circum: >35
hi BP: >120/80 insulin resistance: FBS >100
Term
prediabetes
Definition
impaired fasting glucose (>100mg/dL)
impaired glucose tolerance: 2hr BG b/t 140 & 199mg/dL
Term
CM of DM
Definition
3 Ps:
Polyuria
Polydipsia
Polyphagia
pee, thirst, and hunger
Term
Pt appears tired, complains of intermittent blurred vision, and is on their second granola bar during your assessment, they might be suffering from
Definition
DM
Term
DKA
Definition
diabetic ketoacidosis: lack of glucose use leads to excess breakdown of fatty acids for fuel creating ketones as a byproduct, increases H+ (metabolic acidosis)
Term
HHS
Definition
hyperglycemic hyperosmotic state: diabetes--> hyperglycemia--> hyperosmosis--> poor perfusion to tissues--> dehydration & malnutrtion
Term
system most affected by chronic diabetes
Definition
peripheral vasculature: retinopathies, neuropathies, nephropathies, and foot ulcers
Term
hypoglycemia
Definition
low blood sugar can be caused by insulin overdose in DMII pts
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