Term
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Definition
NEURONS: HUGH BETZ cell motor cortex
TINY granule cells cerebellum
GLIA: neuroECTOdermal
ASTROCYTES: support, repair, BBB
OLIGODENDROCYTES: produce myelin
EPENDYMAL:line ventricle make CSF
MICROGLIA: mesoderm phagocytes from
macrophage and monocyte line |
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Term
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Definition
Chromotolysis: axonal rxn
Red Neuron
Neruonal atrophy: degeneration
Intraneruonal deposits |
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Term
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Definition
rxn of perikaryon to injurs ... axonal trasection ... swelling of cell body w/ peripheral displancement of nucleus and Nissl substance
crush laceration to axon or poliomyelitis |
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Term
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Definition
acute injury leading to cell death
SHRINKAGE of cell body
intense EOSINOPHILIA of cytoplasm
PYKNOSIS of nucleus and LOSS Nissl Body
irreversible, hypoxia, hypoxiemia, ischemia |
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Term
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Definition
LIPOFUSCIN: aging
Ca2+: tumor
VIRAL: Cowdry bodies = herpes
Nergi bodies = rabies
DEGENERATIVE DZ:
Neurofibrillary tangle = Alz
Lewy bodies = Parkinson |
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Term
| NEURONAL ATROPY (DEGENERATION) |
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Definition
neron SHRIVELS and becomes HYPERCHROMATIC, gradual death and loss of neruons secondary to PROGRESSIVE disease (ALS)
irreversible chronic |
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Term
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Definition
H&E stain only nuclei seen
metalic impregnation tech = goligi mech
mutitple CYTOPLASMIC branchin processes
+GFAP (Glial Fibriallary protein =
immuno stain
BBB and CSF BB
help repair ... reactive = gemistocytes
respond to injury = gliosis = glial scar = NO CT or fibroblasts
fibrially astrocytes ==> astrocytomas
in white matter
protoplasmic astrocytes in gray matter
have CD4 marker attach HIV |
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Term
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Definition
astrocytes response to injury
glial scar = no fibroblast or CT
cell body expands (see lots pink cytoplasm) |
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Term
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Definition
produce and maintain CNS myelin
(Schwann cell in PNS)
few dendrites
HORTEGA'S silver imporenation
H&E stain nucleus is dark, round and suround by clear halo (fried eggs)
contain MBP = myelin binding protein
MAG = myelin ass glycoprotien
in WHITE matter along axons
do NOT regenerate do NOT effect remyelinate (MS) |
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Term
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Definition
single cuboidal cells, ciliated
line ventricles, aqueduct of Sylvius, cental canal of sinal cord
rest on subependymas glia
do NOT regenerate
injury causes SUBEPENDYMAL ASTROCYTIC prolifer = EPENDYMAL GRANULATIONS ==> obstruction of aqueduct ==> HYDROCEPEPHALUS ... CHOROID PLEXUS EPITH ... produce CSF |
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Term
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Definition
from MESODERMAL bone marrow origin
from macrophage or monocyte origin
mobile & phagocytic (CR3+, CD68+, CD4+)
H&E elongated ... on HORTEGA silver stain fine cytoplasmic processes
neruosyphillis "ROD CELLS" when activated |
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Term
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Definition
| infects causes damage ... inflam ... granulations ... congenital hydrocephalus |
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Term
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Definition
breakdown myelin, engult and show minute vacoules ... "GLITTER" cells
viral disease ... ricketsia --> microglial nodules
tumors of microglia are lymphomas NOT gliomas ... 1' CNS LYMPHOMAS |
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