Term
|
Definition
Source: Mast cells and platelets
Increase vascular leakage |
|
|
Term
|
Definition
Source: Plasma substrate
Increase vascular leakage
PAIN |
|
|
Term
|
Definition
Source: Plasma protein via liver
Increase vascular leakage
OPSONIC FRAGMENT (C3b) |
|
|
Term
|
Definition
Source: Macrophages
Increase vascular leakage
Increase chemotaxis
LEUKOCYTE ADHESION AND ACTIVATION |
|
|
Term
|
Definition
Source: Mast cells from phspholipids
Potentiate other mediators
VASODILATION, PAIN, FEVER |
|
|
Term
|
Definition
Source: Leukocytes
Increase chemotaxis
LEUKOCYTE ADHESION AND ACTIVATION |
|
|
Term
|
Definition
Source: Leukocytes, Mast Cells
Increase vascular leakage
BRONCHOCONSTRICTION, VASOCONSTRICTION |
|
|
Term
|
Definition
Source: Leukocytes
Increase vascular leakage
ENDOTHELIAL DAMAGE, TISSUE DAMAGE |
|
|
Term
| PAF- Platelet Aggregation Factor |
|
Definition
Source: Leukocytes and Mast Cells
Increase vascular leakage and chemotaxis
BRONCHOCONSTRICTION, LEUKOCYTE PRIMING |
|
|
Term
|
Definition
Source: Macrophages, etc.
Increase chemotaxis
ACUTE ACUTE ACUTE ACUTE ACUTE-PHASE
ENDOTHELIAL ACTIVATION |
|
|
Term
|
Definition
Source: Leukocytes, etc.
Increase chemotaxis
LEUKOCYTE ACTIVATION |
|
|
Term
|
Definition
Source: Macrophages, endothelium
Increase vascular leakage and chemotaxis
VASODILATION, CYTOTOXICITY |
|
|
Term
| What mediators are involved in vasodilation? |
|
Definition
Prostaglandins (Prostacyclin)
Nitric Oxide (maintains vasodilation)
Histamine (starts vasodilation) |
|
|
Term
| What mediators are involved in increasing vascular permeability? |
|
Definition
Vasoactive Amines
C3a and C5a
Bradykinin
Leukotriens C4, D4, E4
PAF
Substance P |
|
|
Term
| What mediators are involved in chemotaxis, leukocyte recruitment, and activation? |
|
Definition
C5a
Leukotriene B4
Chemokines
IL-1,TNF
Bacterial products |
|
|
Term
| What mediators are involved in fever? |
|
Definition
|
|
Term
| What mediators are involved in pain? |
|
Definition
|
|
Term
| What mediators are involved in tissue damage? |
|
Definition
Neutrophils and macrophage lysosomal enzymes
Oxygen metabolites (ROS)
Nitric Oxide |
|
|
Term
| What is the role of P-selectin? |
|
Definition
| Rolling (neutrophils, monocytes, T lymphocytes) |
|
|
Term
| What is the role of E-selectin? |
|
Definition
| Rolling and adhesion (neutrophils, monocytes, T lymphocytes) |
|
|
Term
| What is the role of L-selectin? |
|
Definition
| Rolling (neutrophils, monocytes) |
|
|
Term
| What is the role of ICAM-1? |
|
Definition
| Adhesion, arrest, transmigration (neutrophils, monocytes, lymphocytes) |
|
|
Term
| What is the role of VCAM-1? |
|
Definition
| Adhesion (eosinophils, monocytes, lymphocytes) |
|
|
