Term
| Vascular Changes in Inflammation |
|
Definition
Dilatation
Increased vascular permeability
Transcytosis(VEGF)
Emigration of Leukocytes
Statis(Vascular congestion) |
|
|
Term
|
Definition
Transudate: Mostly fluid, low protein.
Cirrhosis of liver, CHF. In cirrhosis liver cannot make albumin(nothing to hold water in blood)
Euxudate: Fluid and high protein. Vasodilation and statis. Inflammation. Cancer can cause |
|
|
Term
| Lymph Nodes enlarge through what mechanism? |
|
Definition
|
|
Term
| Lymphangitis vs Lympadenitis |
|
Definition
Lymphangitis: Lymphatic vessels inflamed
Red streaks near skin wound.
Lymphadenitis: Lymp NODES inflamed. Painful enlargment of lymph nodes. |
|
|
Term
| Recruitment of leukocytes to sites of infection and injury |
|
Definition
Margination(move outside)
Rolling(selectins)
Adhesion(Integrins)
Migration through endothelium
Edema -> Neutrophils -> monocytes/macrophages |
|
|
Term
| Chronic Granulomatous Disease |
|
Definition
Defect in NADPH Oxidase
Can't generate ROS for oxidative burst
Can phagocytize but not degrade |
|
|
Term
|
Definition
Lysosomal traffcking protein mutation
Decreased leukocyte function
Lysosomes cant fuse with phagosomes
Low platelet counts
Albinism |
|
|
Term
| Resident cells in inflammation |
|
Definition
Mast cells and tissue macrophages
Release histamine, leukotrienes and cytokines TNF & IL-1 |
|
|
Term
| Acute Inflammation Cytokines |
|
Definition
TNF
Sources: Macrophages, Mast Cells, T-cells
Effect: ↑Endothelial adhesion molecules, ↑Cytokines; systemic effects
IL-1
Sources: Macrophages, endothelial cells
Effects: Similar to TNF, Greater role in fever.
IL-6
Sources: Macrophages
Effect: Acute-Phase response(systemic effects) |
|
|
Term
Activated Hagemon Factor(XIIa)
Activated by?
Activates what? |
|
Definition
Factor(XIIa)
Activated By collagen
Activates:
- Kinin(pain, Bradykinin)
- Clotting system → Thrombin
- Fibrinolytic System → plasmin and degrades fibri to produce fibrinopeptides which induce inflammation
- Complement system → anaphylatoxins(C3A,C5A)
|
|
|
Term
Acute Inflammation can progress to? |
|
Definition
Acute Inflammation progress to
Resolution: Regains normal function
Healing: Fibrosis, collagen deposition, loss of function
Chronic Inflammation: Angiogenesis, Mononuclear cell
|
|
|
Term
|
Definition
Fibrinous Inflammation
- ↑Vascular permeability aloows fibrinogen to pass through
- Fibrin is formed and deposited in extracellular space
- Fibrinous Exudate common in inflammation of meninges, pericardium, pleura
- If fibrin not removed by macrophages it stimulates ingrowth of fibroblasts and blood vessels → Scar Tissue
|
|
|
Term
Suppurative / Purulent inflammation
(abscess) |
|
Definition
Suppurative / purulant Inflammation
- Production of pus or purulent exudate consisting of neutrophils, liquefactive necrosis, edema fluid
- Abscesses have a central region of nerotic leukocytes and tissue cells
- Outside of this is neutrophils & fibroblastic proliferation.
|
|
|
Term
|
Definition
Ulcer
Violation of muscularis Mucosa.
Regeneration not possible, Scaring
Erosion
No Violation of Muscularis Mucosa
Regeneration Possible
|
|
|
Term
|
Definition
Acute Phase Proteins
- C-RP
- Fibrinogen
- Serum Amyloid A
|
|
|
